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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(20) NanoFolder
MCC 0.659 > 0.193
Average MCC ± 95% Confidence Intervals 0.652 ± 0.056 > 0.263 ± 0.040
Sensitivity 0.586 > 0.222
Positive Predictive Value 0.743 > 0.171
Total TP 3900 > 1480
Total TN 3120289 > 3116876
Total FP 1570 < 7374
Total FP CONTRA 183 < 1096
Total FP INCONS 1168 < 6088
Total FP COMP 219 > 190
Total FN 2755 < 5175
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Multilign(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 3900
Total TN 3120289
Total FP 1570
Total FP CONTRA 183
Total FP INCONS 1168
Total FP COMP 219
Total FN 2755
Total Scores
MCC 0.659
Average MCC ± 95% Confidence Intervals 0.652 ± 0.056
Sensitivity 0.586
Positive Predictive Value 0.743
Nr of predictions 108

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00083 0.82 0.74 0.91 81 62392 10 0 8 2 29
ASE_00185 0.42 0.38 0.47 48 73434 58 2 52 4 80
ASE_00190 0.46 0.37 0.57 33 45393 28 4 21 3 57
ASE_00221 0.65 0.56 0.74 66 64531 24 0 23 1 51
ASE_00228 0.69 0.67 0.72 58 46890 26 4 19 3 28
ASE_00229 0.60 0.57 0.63 50 42406 32 4 26 2 37
ASE_00231 0.44 0.40 0.50 38 47819 42 3 35 4 58
ASE_00234 0.68 0.60 0.76 78 75363 27 6 19 2 51
ASE_00238 0.50 0.45 0.55 51 64169 42 6 35 1 63
ASE_00254 0.48 0.46 0.50 38 36780 39 5 33 1 44
ASE_00257 0.70 0.64 0.78 62 50960 25 1 17 7 35
ASE_00267 0.75 0.68 0.82 60 45077 21 1 12 8 28
ASE_00270 0.56 0.49 0.64 63 72292 38 2 33 3 65
ASE_00274 0.59 0.51 0.67 53 55532 28 5 21 2 50
ASE_00277 0.79 0.75 0.83 68 48123 16 0 14 2 23
ASE_00279 0.78 0.73 0.82 74 53211 20 2 14 4 27
ASE_00285 0.58 0.51 0.67 62 68914 32 3 27 2 60
ASE_00287 0.62 0.56 0.68 58 54861 28 0 27 1 45
ASE_00294 0.75 0.63 0.89 108 114359 16 1 13 2 63
ASE_00298 0.48 0.43 0.53 49 67435 46 2 42 2 64
ASE_00321 0.73 0.69 0.77 61 54536 25 3 15 7 27
ASE_00340 0.58 0.54 0.63 46 45983 31 8 19 4 39
ASE_00367 0.57 0.53 0.61 46 42995 36 1 29 6 40
ASE_00370 0.86 0.81 0.92 68 41831 14 0 6 8 16
ASE_00372 0.67 0.59 0.77 59 51926 19 1 17 1 41
ASE_00376 0.66 0.61 0.71 64 56863 28 1 25 2 41
ASE_00377 0.61 0.55 0.69 59 57544 29 3 24 2 48
ASE_00386 0.65 0.60 0.70 58 50320 27 5 20 2 38
ASE_00393 0.70 0.63 0.77 59 47818 20 1 17 2 34
ASE_00412 0.56 0.50 0.62 53 58226 34 3 29 2 52
ASE_00413 0.60 0.57 0.64 46 44479 27 2 24 1 35
ASE_00416 0.69 0.59 0.80 75 77327 28 1 18 9 52
ASE_00422 0.65 0.63 0.67 59 46883 30 4 25 1 35
ASE_00427 0.17 0.20 0.15 9 40695 59 19 32 8 37
ASE_00428 0.57 0.54 0.60 68 76522 47 4 42 1 57
ASE_00430 0.79 0.76 0.82 74 46881 16 2 14 0 23
ASE_00437 0.67 0.60 0.75 81 79293 27 1 26 0 54
ASE_00451 0.68 0.60 0.77 75 70779 24 1 21 2 50
CRW_01535 0.92 0.89 0.94 33 7105 4 0 2 2 4
CRW_01539 0.80 0.76 0.85 28 7107 8 0 5 3 9
CRW_01563 0.87 0.81 0.94 30 6871 2 0 2 0 7
CRW_01583 0.88 0.78 1.00 29 7111 1 0 0 1 8
CRW_01590 0.74 0.65 0.86 24 7112 7 0 4 3 13
CRW_01593 0.79 0.78 0.81 29 7104 9 0 7 2 8
CRW_01595 0.89 0.86 0.91 32 8480 5 0 3 2 5
CRW_01603 0.72 0.59 0.88 22 7115 6 0 3 3 15
CRW_01617 0.92 0.89 0.94 33 7105 3 0 2 1 4
CRW_01625 0.89 0.86 0.91 32 7105 6 0 3 3 5
PDB_00070 0.93 0.88 1.00 21 2829 0 0 0 0 3
PDB_00571 0.85 0.76 0.95 19 3301 1 1 0 0 6
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_01236 0.88 0.81 0.96 44 11582 3 0 2 1 10
RFA_00416 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 0.91 0.83 1.00 10 893 1 0 0 1 2
SPR_00066 1.00 1.00 1.00 21 2829 0 0 0 0 0
SPR_00314 1.00 1.00 1.00 21 2905 2 0 0 2 0
SPR_00333 0.98 0.95 1.00 20 2755 0 0 0 0 1
SPR_00353 1.00 1.00 1.00 21 2829 0 0 0 0 0
SPR_00452 0.98 0.95 1.00 20 2830 0 0 0 0 1
SPR_00456 0.73 0.76 0.70 16 2827 7 1 6 0 5
SPR_00476 1.00 1.00 1.00 21 2754 0 0 0 0 0
SPR_00496 1.00 1.00 1.00 21 2754 0 0 0 0 0
SPR_00497 1.00 1.00 1.00 21 2754 0 0 0 0 0
SPR_00502 0.83 0.81 0.85 17 2906 3 0 3 0 4
SPR_00509 1.00 1.00 1.00 20 2906 0 0 0 0 0
SPR_00512 1.00 1.00 1.00 20 2906 0 0 0 0 0
SPR_00557 0.98 0.95 1.00 20 2830 0 0 0 0 1
SPR_00868 1.00 1.00 1.00 21 2905 0 0 0 0 0
SPR_00957 0.79 0.81 0.77 17 2981 6 0 5 1 4
SPR_01040 0.95 0.95 0.95 20 2754 2 0 1 1 1
SRP_00038 0.89 0.85 0.93 28 5020 2 0 2 0 5
SRP_00046 0.00 0.00 0.00 0 4753 0 0 0 0 32
SRP_00103 0.77 0.71 0.84 72 45365 14 1 13 0 30
SRP_00170 0.70 0.56 0.88 14 4079 3 1 1 1 11
SRP_00173 0.61 0.43 0.87 39 38181 8 0 6 2 51
SRP_00194 0.00 0.00 0.00 0 3240 0 0 0 0 21
SRP_00234 0.80 0.78 0.83 67 36234 20 1 13 6 19
SRP_00243 0.47 0.23 1.00 7 5144 0 0 0 0 24
SRP_00244 0.00 0.00 0.00 0 6892 11 1 10 0 39
SRP_00266 0.00 0.00 0.00 0 4656 0 0 0 0 29
SRP_00269 0.00 0.00 0.00 0 5043 7 1 6 0 33
SRP_00273 0.55 0.30 1.00 12 6774 0 0 0 0 28
SRP_00303 0.31 0.09 1.00 3 6667 0 0 0 0 29
SRP_00308 0.65 0.48 0.89 42 36268 5 0 5 0 46
SRP_00317 0.84 0.80 0.90 78 45063 14 1 8 5 20
SRP_00333 0.00 0.00 0.00 0 5151 0 0 0 0 34
SRP_00338 0.00 0.00 0.00 0 5460 0 0 0 0 36
SRP_00342 0.46 0.28 0.78 7 3996 4 0 2 2 18
SRP_00358 0.32 0.14 0.71 5 6321 2 1 1 0 30
SRP_00383 0.54 0.29 1.00 7 3233 0 0 0 0 17
TMR_00123 0.64 0.59 0.68 60 66342 34 4 24 6 41
TMR_00399 0.48 0.45 0.52 42 64899 46 9 30 7 52
TMR_00443 0.67 0.59 0.77 61 67082 22 4 14 4 43
TMR_00469 0.75 0.73 0.78 73 64526 30 7 14 9 27
TMR_00519 0.60 0.57 0.64 54 63106 34 12 18 4 41
TMR_00528 0.51 0.45 0.58 44 63114 37 10 22 5 53
TMR_00571 0.69 0.65 0.73 64 60638 34 10 14 10 35
TMR_00584 0.65 0.61 0.69 59 60989 36 6 21 9 38

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 1480
Total TN 3116876
Total FP 7374
Total FP CONTRA 1096
Total FP INCONS 6088
Total FP COMP 190
Total FN 5175
Total Scores
MCC 0.193
Average MCC ± 95% Confidence Intervals 0.263 ± 0.040
Sensitivity 0.222
Positive Predictive Value 0.171
Nr of predictions 108

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00231 0.37 0.42 0.33 40 47773 84 17 65 2 56
ASE_00234 0.25 0.27 0.23 35 75315 117 10 106 1 94
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00254 0.15 0.16 0.14 13 36761 88 3 79 6 69
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00274 0.00 0.00 0.00 0 55487 126 12 112 2 103
ASE_00277 0.10 0.12 0.08 11 48071 123 23 100 0 80
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00287 0.15 0.17 0.14 17 54824 107 14 91 2 86
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00321 0.11 0.14 0.09 12 54484 122 22 97 3 76
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00370 0.03 0.04 0.03 3 41796 109 18 88 3 81
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00377 0.25 0.27 0.23 29 57505 98 10 86 2 78
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00413 0.08 0.10 0.07 8 44438 108 19 86 3 73
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00427 0.06 0.09 0.04 4 40651 105 35 65 5 42
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
CRW_01535 0.20 0.24 0.17 9 7088 43 7 36 0 28
CRW_01539 0.10 0.11 0.10 4 7099 40 1 36 3 33
CRW_01563 0.11 0.14 0.11 5 6856 43 5 37 1 32
CRW_01583 0.36 0.41 0.33 15 7095 31 8 22 1 22
CRW_01590 -0.01 0.00 0.00 0 7093 50 7 40 3 37
CRW_01593 0.32 0.38 0.29 14 7091 36 5 30 1 23
CRW_01595 -0.01 0.00 0.00 0 8459 57 10 46 1 37
CRW_01603 0.41 0.46 0.38 17 7095 29 6 22 1 20
CRW_01617 0.20 0.24 0.17 9 7087 45 7 37 1 28
CRW_01625 0.43 0.49 0.38 18 7093 31 7 22 2 19
PDB_00070 0.25 0.29 0.23 7 2819 24 4 20 0 17
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_01236 0.31 0.33 0.30 18 11568 43 3 39 1 36
RFA_00416 0.94 1.00 0.88 15 1468 6 2 0 4 0
RFA_00434 0.84 1.00 0.71 15 1410 8 6 0 2 0
RFA_00436 0.86 1.00 0.75 15 1411 7 5 0 2 0
RFA_00442 0.94 1.00 0.88 15 1414 4 2 0 2 0
RFA_00664 -0.01 0.00 0.00 0 978 13 0 12 1 14
RFA_00674 0.12 0.14 0.13 2 1112 15 0 14 1 12
RFA_00675 0.28 0.29 0.29 4 976 10 1 9 0 10
RFA_00677 0.62 0.64 0.60 9 975 10 0 6 4 5
RFA_00717 0.64 0.64 0.64 9 889 5 2 3 0 5
RFA_00730 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00763 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00765 0.39 0.42 0.38 5 890 9 2 6 1 7
SPR_00066 0.47 0.57 0.39 12 2819 20 4 15 1 9
SPR_00314 0.47 0.57 0.39 12 2895 21 9 10 2 9
SPR_00333 0.25 0.33 0.21 7 2741 27 10 17 0 14
SPR_00353 0.64 0.81 0.52 17 2817 16 8 8 0 4
SPR_00452 0.27 0.33 0.23 7 2820 24 7 16 1 14
SPR_00456 0.49 0.57 0.43 12 2822 19 5 11 3 9
SPR_00476 0.47 0.52 0.42 11 2749 17 4 11 2 10
SPR_00496 0.47 0.57 0.40 12 2745 22 7 11 4 9
SPR_00497 0.27 0.33 0.23 7 2745 23 5 18 0 14
SPR_00502 0.27 0.33 0.23 7 2896 26 2 21 3 14
SPR_00509 0.23 0.30 0.19 6 2895 25 8 17 0 14
SPR_00512 0.61 0.75 0.50 15 2896 15 6 9 0 5
SPR_00557 0.42 0.52 0.34 11 2818 22 8 13 1 10
SPR_00868 0.49 0.57 0.43 12 2898 19 5 11 3 9
SPR_00957 0.63 0.76 0.53 16 2973 15 7 7 1 5
SPR_01040 0.15 0.19 0.13 4 2744 27 4 23 0 17
SRP_00038 0.23 0.27 0.20 9 5005 36 1 35 0 24
SRP_00046 0.33 0.38 0.29 12 4712 30 3 26 1 20
SRP_00103 0.00 0.00 0.00 0 45319 132 14 118 0 102
SRP_00170 0.29 0.36 0.25 9 4059 28 4 23 1 16
SRP_00173 0.00 0.00 0.00 0 38104 124 13 109 2 90
SRP_00194 0.27 0.33 0.23 7 3209 27 5 19 3 14
SRP_00234 0.21 0.24 0.18 21 36200 97 19 75 3 65
SRP_00243 0.47 0.55 0.40 17 5109 25 7 18 0 14
SRP_00244 0.38 0.44 0.34 17 6853 33 2 31 0 22
SRP_00266 0.55 0.66 0.46 19 4615 22 8 14 0 10
SRP_00269 0.46 0.52 0.43 17 5010 24 6 17 1 16
SRP_00273 0.36 0.40 0.33 16 6737 34 6 27 1 24
SRP_00303 0.36 0.41 0.33 13 6630 27 3 24 0 19
SRP_00308 0.14 0.17 0.12 15 36189 112 18 93 1 73
SRP_00317 0.14 0.16 0.12 16 45018 116 16 100 0 82
SRP_00333 0.20 0.24 0.19 8 5108 35 3 32 0 26
SRP_00338 0.52 0.56 0.49 20 5419 22 4 17 1 16
SRP_00342 0.20 0.24 0.17 6 3970 29 7 22 0 19
SRP_00358 0.32 0.37 0.28 13 6282 33 4 29 0 22
SRP_00383 -0.01 0.00 0.00 0 3205 35 9 26 0 24
TMR_00123 0.19 0.23 0.16 23 66283 126 20 104 2 78
TMR_00399 0.20 0.26 0.16 24 64833 130 38 85 7 70
TMR_00443 0.17 0.20 0.15 21 67018 126 24 98 4 83
TMR_00469 0.10 0.12 0.08 12 64469 145 27 112 6 88
TMR_00519 0.04 0.05 0.03 5 63046 141 33 106 2 90
TMR_00528 0.13 0.15 0.11 15 63051 131 20 104 7 82
TMR_00571 0.05 0.06 0.04 6 60577 149 19 124 6 93
TMR_00584 0.01 0.01 0.01 1 60922 159 33 119 7 96

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.