CompaRNA - on-line benchmarks of RNA structure prediction methods

FAQ

Metric	Multilign(seed)		Afold
MCC	0.697	>	0.589
Average MCC ± 95% Confidence Intervals	0.534 ± 0.157	>	0.527 ± 0.124
Sensitivity	0.651	>	0.592
Positive Predictive Value	0.747	>	0.588
Total TP	458	>	416
Total TN	322070	>	321975
Total FP	232	<	392
Total FP CONTRA	29	<	73
Total FP INCONS	126	<	219
Total FP COMP	77	<	100
Total FN	245	<	287
P-value	3.51155234096e-08

Comparison of performance of Multilign(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Afold).

Total Scores
MCC	0.697
Average MCC ± 95% Confidence Intervals	0.534 ± 0.157
Sensitivity	0.651
Positive Predictive Value	0.747
Nr of predictions	19

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00416	Hammerhead_3 links to Rfam database...	0.57	0.53	0.62	8	1472	6	1	4	1	7
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	20	0	4	16	13
RFA_00628	rne5 links to Rfam database...	0.92	0.88	0.95	76	57211	18	0	4	14	10
RFA_00630	rne5 links to Rfam database...	0.83	0.80	0.86	70	56872	29	0	11	18	17
RFA_00654	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2414	1	0	1	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1128	0	0	0	0	14
RFA_00664	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1035	0	0	0	0	14
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1876	5	0	5	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	0	2	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00808	RydC links to Rfam database...	0.60	0.56	0.64	9	2002	5	0	5	0	7
RFA_00809	RydC links to Rfam database...	0.37	0.38	0.38	6	2129	10	1	9	0	10
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	12	0	0	12	0
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	12	1	3	8	8
SRP_00241	Plant_SRP links to Rfam database...	0.48	0.50	0.46	41	45967	50	15	33	2	41
SRP_00340	Metazoa_SRP links to Rfam database...	0.59	0.61	0.57	50	41240	44	7	31	6	32

Total Scores
MCC	0.589
Average MCC ± 95% Confidence Intervals	0.527 ± 0.124
Sensitivity	0.592
Positive Predictive Value	0.588
Nr of predictions	19

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00654	Vimentin3 links to Rfam database...	0.27	0.28	0.28	5	2397	14	2	11	1	13
RFA_00658	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	1116	5	0	3	2	5
RFA_00664	Hammerhead_1 links to Rfam database...	0.07	0.07	0.09	1	979	11	0	10	1	13
RFA_00708	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	1027	3	0	3	0	9
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	5	0	4	1	8
RFA_00768	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	8	1	6	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	10	3	5	2	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	12	1	10	1	10
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.59	0.51	48	45961	50	11	36	3	34
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	47	9	36	2	34

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.