CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Multilign(seed)		MXScarna(seed)
MCC	0.698	>	0.686
Average MCC ± 95% Confidence Intervals	0.555 ± 0.136	<	0.640 ± 0.099
Sensitivity	0.660	<	0.662
Positive Predictive Value	0.741	>	0.712
Total TP	560	<	562
Total TN	383500	>	383467
Total FP	279	<	376
Total FP CONTRA	36	<	47
Total FP INCONS	160	<	180
Total FP COMP	83	<	149
Total FN	289	>	287
P-value	1.27663599501e-06

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Performance plots

Comparison of performance of Multilign(seed) and MXScarna(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and MXScarna(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(seed) and MXScarna(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and MXScarna(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and MXScarna(seed)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP	560
Total TN	383500
Total FP	279
Total FP CONTRA	36
Total FP INCONS	160
Total FP COMP	83
Total FN	289

Total Scores
MCC	0.698
Average MCC ± 95% Confidence Intervals	0.555 ± 0.136
Sensitivity	0.660
Positive Predictive Value	0.741
Nr of predictions	22

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00416	Hammerhead_3 links to Rfam database...	0.57	0.53	0.62	8	1472	6	1	4	1	7
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	20	0	4	16	13
RFA_00628	rne5 links to Rfam database...	0.92	0.88	0.95	76	57211	18	0	4	14	10
RFA_00630	rne5 links to Rfam database...	0.83	0.80	0.86	70	56872	29	0	11	18	17
RFA_00654	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2414	1	0	1	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1128	0	0	0	0	14
RFA_00664	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1035	0	0	0	0	14
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1876	5	0	5	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	0	2	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1938	5	0	5	0	8
RFA_00808	RydC links to Rfam database...	0.60	0.56	0.64	9	2002	5	0	5	0	7
RFA_00809	RydC links to Rfam database...	0.37	0.38	0.38	6	2129	10	1	9	0	10
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	12	0	0	12	0
RFA_00817	R2_retro_el links to Rfam database...	0.77	0.78	0.76	32	21903	13	5	5	3	9
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	12	1	3	8	8
SRP_00241	Plant_SRP links to Rfam database...	0.48	0.50	0.46	41	45967	50	15	33	2	41
SRP_00331	Metazoa_SRP links to Rfam database...	0.69	0.69	0.70	60	37589	29	2	24	3	27
SRP_00340	Metazoa_SRP links to Rfam database...	0.59	0.61	0.57	50	41240	44	7	31	6	32

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Performance of MXScarna(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	562
Total TN	383467
Total FP	376
Total FP CONTRA	47
Total FP INCONS	180
Total FP COMP	149
Total FN	287

Total Scores
MCC	0.686
Average MCC ± 95% Confidence Intervals	0.640 ± 0.099
Sensitivity	0.662
Positive Predictive Value	0.712
Nr of predictions	22

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00416	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	1	0	0	1	1
RFA_00626	rne5 links to Rfam database...	0.89	0.87	0.92	76	56533	29	2	5	22	11
RFA_00628	rne5 links to Rfam database...	0.85	0.81	0.89	70	57212	38	2	7	29	16
RFA_00630	rne5 links to Rfam database...	0.82	0.78	0.86	68	56874	33	2	9	22	19
RFA_00654	Vimentin3 links to Rfam database...	0.73	0.67	0.80	12	2400	5	0	3	2	6
RFA_00658	Hammerhead_1 links to Rfam database...	0.61	0.57	0.67	8	1116	5	0	4	1	6
RFA_00664	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	978	4	0	3	1	5
RFA_00708	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	1024	4	0	3	1	6
RFA_00767	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	2	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1875	6	2	4	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.57	0.56	0.59	10	1999	7	2	5	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.57	0.56	0.59	10	1936	7	2	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2000	19	2	14	3	16
RFA_00809	RydC links to Rfam database...	0.30	0.31	0.29	5	2128	12	1	11	0	11
RFA_00816	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	23182	15	0	0	15	3
RFA_00817	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	21909	12	0	0	12	5
RFA_00818	R2_retro_el links to Rfam database...	0.64	0.68	0.61	28	20255	30	11	7	12	13
SRP_00241	Plant_SRP links to Rfam database...	0.50	0.51	0.49	42	45970	54	8	36	10	40
SRP_00331	Metazoa_SRP links to Rfam database...	0.55	0.48	0.64	42	37609	30	1	23	6	45
SRP_00340	Metazoa_SRP links to Rfam database...	0.58	0.56	0.60	46	41251	43	4	27	12	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

2. Individual counts for Multilign(seed) [ download as .csv ]

Performance of MXScarna(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]