CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CMfinder(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & CMfinder(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) CMfinder(seed)
MCC 0.764 > 0.486
Average MCC ± 95% Confidence Intervals 0.713 ± 0.044 > 0.505 ± 0.044
Sensitivity 0.661 > 0.312
Positive Predictive Value 0.882 > 0.757
Total TP 4033 > 1905
Total TN 2879179 < 2881233
Total FP 919 > 688
Total FP CONTRA 50 > 40
Total FP INCONS 488 < 572
Total FP COMP 381 > 76
Total FN 2064 < 4192
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CMfinder(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CMfinder(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CMfinder(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 4033
Total TN 2879179
Total FP 919
Total FP CONTRA 50
Total FP INCONS 488
Total FP COMP 381
Total FN 2064
Total Scores
MCC 0.764
Average MCC ± 95% Confidence Intervals 0.713 ± 0.044
Sensitivity 0.661
Positive Predictive Value 0.882
Nr of predictions 129

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.41 0.25 0.66 29 103696 18 0 15 3 86
CRW_00016 0.40 0.24 0.66 29 77377 17 0 15 2 91
CRW_00610 0.54 0.38 0.76 31 36274 12 1 9 2 50
CRW_00613 0.40 0.29 0.55 23 34938 22 1 18 3 55
CRW_00614 0.49 0.39 0.63 22 121736 16 2 11 3 35
CRW_00618 0.38 0.28 0.52 17 56247 16 2 14 0 44
CRW_00633 0.38 0.24 0.61 25 63505 16 2 14 0 81
CRW_00634 0.31 0.19 0.50 18 64584 24 1 17 6 76
CRW_00670 0.51 0.31 0.84 37 70081 8 0 7 1 83
CRW_00671 0.52 0.32 0.84 37 62791 8 0 7 1 80
CRW_00672 0.52 0.32 0.84 36 72347 10 0 7 3 75
CRW_00674 0.25 0.15 0.45 18 83396 25 6 16 3 106
CRW_00676 0.29 0.16 0.53 18 93494 24 0 16 8 97
CRW_00692 0.32 0.20 0.53 18 68601 24 0 16 8 72
PDB_00005 0.80 0.64 1.00 9 937 0 0 0 0 5
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 0.68 0.57 0.81 13 2685 3 0 3 0 10
PDB_00810 0.87 0.76 1.00 13 1068 0 0 0 0 4
PDB_00827 0.50 0.37 0.68 30 26984 14 2 12 0 51
PDB_01050 0.48 0.38 0.63 5 622 4 0 3 1 8
PDB_01051 0.96 0.92 1.00 12 891 4 0 0 4 1
PDB_01092 0.68 0.56 0.83 29 10118 8 0 6 2 23
PDB_01152 0.80 0.71 0.91 10 550 1 0 1 0 4
RFA_00603 0.96 0.91 1.00 32 13498 0 0 0 0 3
RFA_00604 0.96 0.91 1.00 32 13498 0 0 0 0 3
RFA_00605 0.96 0.91 1.00 32 15193 0 0 0 0 3
RFA_00606 0.91 0.82 1.00 32 21289 0 0 0 0 7
RFA_00607 0.94 0.89 1.00 32 17734 0 0 0 0 4
RFA_00609 0.93 0.86 1.00 32 17923 0 0 0 0 5
RFA_00610 0.93 0.86 1.00 32 17173 0 0 0 0 5
RFA_00611 0.96 0.91 1.00 32 13009 0 0 0 0 3
RFA_00613 0.96 0.91 1.00 32 12848 0 0 0 0 3
RFA_00615 0.85 0.80 0.90 28 13335 3 0 3 0 7
RFA_00620 0.89 0.79 1.00 31 21914 0 0 0 0 8
RFA_00626 0.96 0.92 1.00 80 56536 7 0 0 7 7
RFA_00627 0.96 0.93 1.00 81 56872 12 0 0 12 6
RFA_00628 0.96 0.93 1.00 80 57211 12 0 0 12 6
RFA_00630 0.92 0.87 0.97 76 56875 17 0 2 15 11
RFA_00632 0.69 0.64 0.75 18 4071 6 2 4 0 10
RFA_00636 0.73 0.68 0.79 19 3981 5 2 3 0 9
RFA_00639 0.71 0.66 0.78 57 54542 18 2 14 2 30
RFA_00642 0.35 0.28 0.45 5 2915 6 0 6 0 13
RFA_00643 0.34 0.28 0.42 5 2199 7 0 7 0 13
RFA_00644 0.34 0.28 0.42 5 2689 7 0 7 0 13
RFA_00645 0.34 0.28 0.42 5 2403 7 0 7 0 13
RFA_00649 0.34 0.28 0.42 5 2133 7 0 7 0 13
RFA_00651 0.34 0.28 0.42 5 2068 7 0 7 0 13
RFA_00653 0.34 0.28 0.42 5 2133 7 0 7 0 13
RFA_00654 0.34 0.28 0.42 5 2403 7 0 7 0 13
RFA_00658 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00659 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00664 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00667 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00668 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00672 0.45 0.31 0.67 4 897 3 0 2 1 9
RFA_00673 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00674 0.54 0.36 0.83 5 1122 2 0 1 1 9
RFA_00675 0.40 0.21 0.75 3 986 2 0 1 1 11
RFA_00677 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00704 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00705 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00709 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00710 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.56 0.43 0.75 6 895 2 0 2 0 8
RFA_00730 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00731 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00733 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00734 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00736 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00737 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00745 1.00 1.00 1.00 12 934 1 0 0 1 0
RFA_00749 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00758 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00762 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00763 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00764 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00765 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00769 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00770 0.63 0.56 0.71 10 2002 4 3 1 0 8
RFA_00773 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00779 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00791 0.97 0.94 1.00 30 5121 0 0 0 0 2
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00808 0.71 0.56 0.90 9 2006 1 1 0 0 7
RFA_00809 0.47 0.38 0.60 6 2135 4 0 4 0 10
RFA_00814 0.98 0.95 1.00 39 25161 5 0 0 5 2
RFA_00815 0.98 0.95 1.00 39 24492 6 0 0 6 2
RFA_00816 0.98 0.95 1.00 39 23181 6 0 0 6 2
RFA_00817 0.98 0.95 1.00 39 21906 4 0 0 4 2
RFA_00818 0.98 0.95 1.00 39 20262 3 0 0 3 2
RFA_00819 0.98 0.95 1.00 39 27927 6 0 0 6 2
SRP_00016 0.92 0.87 0.98 95 47798 9 0 2 7 14
SRP_00130 0.79 0.74 0.84 72 49684 29 1 13 15 25
SRP_00142 0.92 0.91 0.93 85 45965 17 0 6 11 8
SRP_00143 0.85 0.81 0.88 82 49677 24 0 11 13 19
SRP_00144 0.92 0.91 0.93 86 46573 18 0 6 12 8
SRP_00197 0.92 0.88 0.96 89 49362 17 1 3 13 12
SRP_00198 0.91 0.87 0.96 90 50946 16 1 3 12 13
SRP_00199 0.89 0.86 0.93 90 50943 17 1 6 10 15
SRP_00201 0.92 0.88 0.95 98 47792 7 2 3 2 13
SRP_00202 0.88 0.81 0.95 95 54185 10 1 4 5 22
SRP_00203 0.81 0.78 0.84 82 48730 21 1 15 5 23
SRP_00204 0.91 0.87 0.95 89 49047 16 0 5 11 13
SRP_00206 0.95 0.92 0.98 99 47794 7 0 2 5 9
SRP_00208 0.93 0.89 0.97 90 46572 14 0 3 11 11
SRP_00255 0.79 0.77 0.81 72 47497 31 1 16 14 22
SRP_00276 0.92 0.87 0.97 96 50622 9 1 2 6 14
SRP_00278 0.85 0.81 0.89 85 45961 15 1 9 5 20
SRP_00321 0.87 0.81 0.94 88 47492 14 1 5 8 20
SRP_00322 0.86 0.81 0.93 88 48421 14 0 7 7 21
SRP_00323 0.91 0.85 0.97 91 47184 13 0 3 10 16
SRP_00330 0.85 0.82 0.89 78 49998 24 1 9 14 17
SRP_00332 0.93 0.89 0.98 94 50307 9 0 2 7 12
SRP_00339 0.85 0.82 0.89 77 44464 21 1 9 11 17

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP 1905
Total TN 2881233
Total FP 688
Total FP CONTRA 40
Total FP INCONS 572
Total FP COMP 76
Total FN 4192
Total Scores
MCC 0.486
Average MCC ± 95% Confidence Intervals 0.505 ± 0.044
Sensitivity 0.312
Positive Predictive Value 0.757
Nr of predictions 129

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.37 0.14 1.00 16 103724 0 0 0 0 99
CRW_00016 0.36 0.14 0.89 17 77402 2 0 2 0 103
CRW_00610 0.49 0.31 0.78 25 36283 7 1 6 0 56
CRW_00613 0.54 0.33 0.87 26 34950 4 0 4 0 52
CRW_00614 0.46 0.25 0.88 14 121755 9 0 2 7 43
CRW_00618 0.36 0.13 1.00 8 56272 0 0 0 0 53
CRW_00633 0.32 0.12 0.81 13 63530 3 1 2 0 93
CRW_00634 0.40 0.17 0.94 16 64603 1 0 1 0 78
CRW_00670 0.32 0.18 0.55 22 70085 18 0 18 0 98
CRW_00671 0.20 0.09 0.41 11 62808 16 0 16 0 106
CRW_00672 0.38 0.15 0.94 17 72372 1 0 1 0 94
CRW_00674 0.40 0.17 0.95 21 83414 1 0 1 0 103
CRW_00676 0.12 0.04 0.33 5 93513 10 1 9 0 110
CRW_00692 0.41 0.17 1.00 15 68620 0 0 0 0 75
PDB_00005 0.47 0.36 0.63 5 938 3 0 3 0 9
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 0.00 0.00 0.00 0 465 0 0 0 0 11
PDB_00716 -0.01 0.00 0.00 0 2688 13 0 13 0 23
PDB_00810 0.76 0.59 1.00 10 1071 0 0 0 0 7
PDB_00827 0.25 0.10 0.62 8 27015 5 0 5 0 73
PDB_01050 0.68 0.46 1.00 6 624 1 0 0 1 7
PDB_01051 0.83 0.69 1.00 9 894 4 0 0 4 4
PDB_01092 0.38 0.21 0.69 11 10137 6 0 5 1 41
PDB_01152 0.92 0.86 1.00 12 549 0 0 0 0 2
RFA_00603 0.70 0.60 0.81 21 13504 7 0 5 2 14
RFA_00604 0.63 0.51 0.78 18 13507 8 0 5 3 17
RFA_00605 0.14 0.06 0.33 2 15219 5 0 4 1 33
RFA_00606 0.34 0.21 0.57 8 21307 8 2 4 2 31
RFA_00607 0.08 0.06 0.13 2 17750 15 3 11 1 34
RFA_00609 0.32 0.22 0.47 8 17938 12 2 7 3 29
RFA_00610 0.39 0.30 0.52 11 17184 13 2 8 3 26
RFA_00611 0.65 0.51 0.82 18 13019 5 0 4 1 17
RFA_00613 0.70 0.57 0.87 20 12857 4 0 3 1 15
RFA_00615 0.57 0.49 0.68 17 13341 10 0 8 2 18
RFA_00620 0.00 0.00 0.00 0 21939 6 0 6 0 39
RFA_00626 0.44 0.32 0.60 28 56569 22 2 17 3 59
RFA_00627 0.53 0.39 0.72 34 56906 15 3 10 2 53
RFA_00628 0.58 0.43 0.77 37 57243 14 3 8 3 49
RFA_00630 0.45 0.32 0.64 28 56909 17 3 13 1 59
RFA_00632 0.27 0.25 0.29 7 4071 17 0 17 0 21
RFA_00636 0.71 0.64 0.78 18 3982 5 2 3 0 10
RFA_00639 0.00 0.00 0.00 0 54575 44 6 34 4 87
RFA_00642 0.44 0.28 0.71 5 2919 2 0 2 0 13
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.00 0.00 0.00 0 2693 8 0 8 0 18
RFA_00645 0.29 0.17 0.50 3 2409 3 0 3 0 15
RFA_00649 0.35 0.22 0.57 4 2138 3 0 3 0 14
RFA_00651 0.35 0.22 0.57 4 2073 3 0 3 0 14
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.38 0.22 0.67 4 2409 2 0 2 0 14
RFA_00658 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00659 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00664 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00667 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00668 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00672 0.41 0.31 0.57 4 896 3 0 3 0 9
RFA_00673 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00674 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00675 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00677 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00704 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00705 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00709 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00710 0.32 0.21 0.50 3 984 3 0 3 0 11
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.30 0.14 0.67 2 943 2 0 1 1 12
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.30 0.21 0.43 3 896 4 0 4 0 11
RFA_00730 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00731 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00733 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00734 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00736 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00737 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00745 0.91 0.83 1.00 10 936 0 0 0 0 2
RFA_00749 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00758 0.86 0.75 1.00 9 894 0 0 0 0 3
RFA_00762 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00763 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00764 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00765 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00769 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00770 0.71 0.50 1.00 9 2007 0 0 0 0 9
RFA_00773 0.00 0.00 0.00 0 1949 4 0 4 0 18
RFA_00779 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00791 0.92 0.88 0.97 28 5122 1 0 1 0 4
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.41 0.38 0.46 6 2132 7 1 6 0 10
RFA_00814 0.68 0.51 0.91 21 25177 2 0 2 0 20
RFA_00815 0.68 0.51 0.91 21 24508 2 0 2 0 20
RFA_00816 0.68 0.51 0.91 21 23197 2 0 2 0 20
RFA_00817 0.68 0.56 0.82 23 21917 5 0 5 0 18
RFA_00818 0.60 0.49 0.74 20 20274 8 1 6 1 21
RFA_00819 0.62 0.51 0.75 21 27938 7 0 7 0 20
SRP_00016 0.54 0.35 0.83 38 47849 8 0 8 0 71
SRP_00130 0.50 0.32 0.78 31 49730 10 1 8 1 66
SRP_00142 0.46 0.37 0.58 34 45997 26 1 24 1 59
SRP_00143 0.50 0.30 0.86 30 49735 5 0 5 0 71
SRP_00144 0.54 0.37 0.80 35 46621 11 0 9 2 59
SRP_00197 0.46 0.26 0.84 26 49424 5 0 5 0 75
SRP_00198 0.56 0.37 0.84 38 50995 7 0 7 0 65
SRP_00199 0.54 0.35 0.82 37 50995 8 0 8 0 68
SRP_00201 0.54 0.35 0.83 39 47848 8 0 8 0 72
SRP_00202 0.43 0.21 0.86 25 54256 4 0 4 0 92
SRP_00203 0.51 0.34 0.77 36 48781 12 0 11 1 69
SRP_00204 0.52 0.34 0.80 35 49097 9 1 8 0 67
SRP_00206 0.55 0.36 0.83 39 47848 8 0 8 0 69
SRP_00208 0.52 0.33 0.83 33 46625 7 1 6 0 68
SRP_00255 0.49 0.27 0.89 25 47558 3 0 3 0 69
SRP_00276 0.51 0.33 0.80 36 50676 9 0 9 0 74
SRP_00278 0.52 0.33 0.81 35 46013 8 0 8 0 70
SRP_00321 0.42 0.21 0.82 23 47558 5 1 4 0 85
SRP_00322 0.52 0.33 0.82 36 48472 8 0 8 0 73
SRP_00323 0.54 0.34 0.88 36 47237 5 0 5 0 71
SRP_00330 0.44 0.23 0.85 22 50060 5 0 4 1 73
SRP_00332 0.44 0.25 0.75 27 50367 9 0 9 0 79
SRP_00339 0.56 0.39 0.79 37 44504 10 2 8 0 57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.