CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Murlet(seed)
MCC 0.800 > 0.540
Average MCC ± 95% Confidence Intervals 0.730 ± 0.042 > 0.396 ± 0.065
Sensitivity 0.740 > 0.360
Positive Predictive Value 0.866 > 0.811
Total TP 3573 > 1738
Total TN 2787512 < 2789495
Total FP 941 > 489
Total FP CONTRA 79 > 21
Total FP INCONS 475 > 385
Total FP COMP 387 > 83
Total FN 1255 < 3090
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 3573
Total TN 2787512
Total FP 941
Total FP CONTRA 79
Total FP INCONS 475
Total FP COMP 387
Total FN 1255
Total Scores
MCC 0.800
Average MCC ± 95% Confidence Intervals 0.730 ± 0.042
Sensitivity 0.740
Positive Predictive Value 0.866
Nr of predictions 123

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01343 0.87 0.85 0.89 367 977489 81 8 37 36 67
PDB_00005 0.80 0.64 1.00 9 937 0 0 0 0 5
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 0.68 0.57 0.81 13 2685 3 0 3 0 10
PDB_00810 0.87 0.76 1.00 13 1068 0 0 0 0 4
PDB_01050 0.48 0.38 0.63 5 622 4 0 3 1 8
PDB_01051 0.96 0.92 1.00 12 891 4 0 0 4 1
PDB_01092 0.68 0.56 0.83 29 10118 8 0 6 2 23
PDB_01152 0.80 0.71 0.91 10 550 1 0 1 0 4
RFA_00390 1.00 1.00 1.00 15 1416 3 0 0 3 0
RFA_00416 1.00 1.00 1.00 15 1470 3 0 0 3 0
RFA_00433 1.00 1.00 1.00 15 1416 3 0 0 3 0
RFA_00587 1.00 1.00 1.00 15 4836 5 0 0 5 0
RFA_00603 0.96 0.91 1.00 32 13498 0 0 0 0 3
RFA_00604 0.96 0.91 1.00 32 13498 0 0 0 0 3
RFA_00605 0.96 0.91 1.00 32 15193 0 0 0 0 3
RFA_00606 0.91 0.82 1.00 32 21289 0 0 0 0 7
RFA_00607 0.94 0.89 1.00 32 17734 0 0 0 0 4
RFA_00609 0.93 0.86 1.00 32 17923 0 0 0 0 5
RFA_00610 0.93 0.86 1.00 32 17173 0 0 0 0 5
RFA_00611 0.96 0.91 1.00 32 13009 0 0 0 0 3
RFA_00613 0.96 0.91 1.00 32 12848 0 0 0 0 3
RFA_00615 0.85 0.80 0.90 28 13335 3 0 3 0 7
RFA_00620 0.89 0.79 1.00 31 21914 0 0 0 0 8
RFA_00626 0.96 0.92 1.00 80 56536 7 0 0 7 7
RFA_00627 0.96 0.93 1.00 81 56872 12 0 0 12 6
RFA_00628 0.96 0.93 1.00 80 57211 12 0 0 12 6
RFA_00630 0.92 0.87 0.97 76 56875 17 0 2 15 11
RFA_00632 0.69 0.64 0.75 18 4071 6 2 4 0 10
RFA_00636 0.73 0.68 0.79 19 3981 5 2 3 0 9
RFA_00639 0.71 0.66 0.78 57 54542 18 2 14 2 30
RFA_00642 0.35 0.28 0.45 5 2915 6 0 6 0 13
RFA_00643 0.34 0.28 0.42 5 2199 7 0 7 0 13
RFA_00644 0.34 0.28 0.42 5 2689 7 0 7 0 13
RFA_00645 0.34 0.28 0.42 5 2403 7 0 7 0 13
RFA_00649 0.34 0.28 0.42 5 2133 7 0 7 0 13
RFA_00651 0.34 0.28 0.42 5 2068 7 0 7 0 13
RFA_00653 0.34 0.28 0.42 5 2133 7 0 7 0 13
RFA_00654 0.34 0.28 0.42 5 2403 7 0 7 0 13
RFA_00658 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00659 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00664 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00667 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00668 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00672 0.45 0.31 0.67 4 897 3 0 2 1 9
RFA_00673 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00674 0.54 0.36 0.83 5 1122 2 0 1 1 9
RFA_00675 0.40 0.21 0.75 3 986 2 0 1 1 11
RFA_00677 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.43 0.29 0.67 4 1122 3 0 2 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00695 0.50 0.36 0.71 5 7014 3 0 2 1 9
RFA_00703 0.44 0.29 0.67 4 4272 3 0 2 1 10
RFA_00704 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00705 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00709 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00710 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.56 0.43 0.75 6 895 2 0 2 0 8
RFA_00730 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00731 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00733 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00734 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00736 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00737 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00745 1.00 1.00 1.00 12 934 1 0 0 1 0
RFA_00749 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00758 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00762 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00763 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00764 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00765 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00767 0.63 0.56 0.71 10 1877 4 3 1 0 8
RFA_00768 0.63 0.56 0.71 10 1877 4 3 1 0 8
RFA_00769 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00770 0.63 0.56 0.71 10 2002 4 3 1 0 8
RFA_00773 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00779 0.63 0.56 0.71 10 1939 4 3 1 0 8
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00791 0.97 0.94 1.00 30 5121 0 0 0 0 2
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00808 0.71 0.56 0.90 9 2006 1 1 0 0 7
RFA_00809 0.47 0.38 0.60 6 2135 4 0 4 0 10
RFA_00814 0.98 0.95 1.00 39 25161 5 0 0 5 2
RFA_00815 0.98 0.95 1.00 39 24492 6 0 0 6 2
RFA_00816 0.98 0.95 1.00 39 23181 6 0 0 6 2
RFA_00817 0.98 0.95 1.00 39 21906 4 0 0 4 2
RFA_00818 0.98 0.95 1.00 39 20262 3 0 0 3 2
RFA_00819 0.98 0.95 1.00 39 27927 6 0 0 6 2
RFA_00820 0.86 0.83 0.90 132 151379 33 1 13 19 28
RFA_00830 0.75 0.73 0.78 112 152485 44 2 29 13 42
SRP_00079 0.76 0.73 0.80 64 41825 30 0 16 14 24
SRP_00124 0.71 0.68 0.74 58 37050 32 3 17 12 27
SRP_00137 0.51 0.48 0.55 12 4164 12 3 7 2 13
SRP_00141 0.65 0.49 0.87 20 6305 5 1 2 2 21
SRP_00146 0.69 0.56 0.87 20 5230 5 1 2 2 16
SRP_00182 0.88 0.84 0.91 85 45963 17 0 8 9 16
SRP_00197 0.92 0.88 0.96 89 49362 17 1 3 13 12
SRP_00198 0.91 0.87 0.96 90 50946 16 1 3 12 13
SRP_00199 0.89 0.86 0.93 90 50943 17 1 6 10 15
SRP_00202 0.88 0.81 0.95 95 54185 10 1 4 5 22
SRP_00241 0.55 0.56 0.55 46 45972 53 9 29 15 36
SRP_00255 0.79 0.77 0.81 72 47497 31 1 16 14 22
SRP_00260 0.55 0.53 0.58 53 47804 46 6 32 8 47
SRP_00278 0.85 0.81 0.89 85 45961 15 1 9 5 20
SRP_00285 0.77 0.63 0.95 19 3721 4 0 1 3 11
SRP_00322 0.86 0.81 0.93 88 48421 14 0 7 7 21
SRP_00328 0.61 0.59 0.64 50 39543 34 5 23 6 35
SRP_00329 0.75 0.72 0.78 61 39825 29 2 15 12 24
SRP_00338 0.76 0.61 0.96 22 5437 3 0 1 2 14
SRP_00339 0.85 0.82 0.89 77 44464 21 1 9 11 17
SRP_00340 0.53 0.52 0.54 43 41249 51 6 30 15 39

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 1738
Total TN 2789495
Total FP 489
Total FP CONTRA 21
Total FP INCONS 385
Total FP COMP 83
Total FN 3090
Total Scores
MCC 0.540
Average MCC ± 95% Confidence Intervals 0.396 ± 0.065
Sensitivity 0.360
Positive Predictive Value 0.811
Nr of predictions 123

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01343 0.64 0.61 0.68 263 977515 145 6 117 22 171
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00012 0.65 0.43 1.00 3 403 0 0 0 0 4
PDB_00213 0.73 0.59 0.92 24 5024 2 0 2 0 17
PDB_00553 0.45 0.27 0.75 3 461 1 0 1 0 8
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_00810 0.63 0.53 0.75 9 1069 3 0 3 0 8
PDB_01050 0.55 0.31 1.00 4 626 1 0 0 1 9
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
PDB_01152 0.76 0.64 0.90 9 551 1 0 1 0 5
RFA_00390 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00416 0.00 0.00 0.00 0 1485 0 0 0 0 15
RFA_00433 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00604 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00605 0.00 0.00 0.00 0 15225 0 0 0 0 35
RFA_00606 0.00 0.00 0.00 0 21321 0 0 0 0 39
RFA_00607 0.00 0.00 0.00 0 17766 0 0 0 0 36
RFA_00609 0.00 0.00 0.00 0 17955 0 0 0 0 37
RFA_00610 0.00 0.00 0.00 0 17205 0 0 0 0 37
RFA_00611 0.00 0.00 0.00 0 13041 0 0 0 0 35
RFA_00613 0.00 0.00 0.00 0 12880 0 0 0 0 35
RFA_00615 0.00 0.00 0.00 0 13366 0 0 0 0 35
RFA_00620 0.00 0.00 0.00 0 21945 0 0 0 0 39
RFA_00626 0.81 0.66 1.00 57 56559 4 0 0 4 30
RFA_00627 0.84 0.70 1.00 61 56892 5 0 0 5 26
RFA_00628 0.83 0.69 1.00 59 57232 8 0 0 8 27
RFA_00630 0.82 0.67 1.00 58 56895 4 0 0 4 29
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00639 0.21 0.11 0.40 10 54590 15 4 11 0 77
RFA_00642 0.57 0.44 0.73 8 2915 3 0 3 0 10
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.42 0.33 0.55 6 2690 5 0 5 0 12
RFA_00645 0.00 0.00 0.00 0 2407 8 0 8 0 18
RFA_00649 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00651 0.42 0.33 0.55 6 2069 5 0 5 0 12
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.57 0.44 0.73 8 2404 3 0 3 0 10
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00659 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00668 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00684 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00685 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00706 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00707 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00710 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00711 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00715 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00731 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00733 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00734 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00736 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00737 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00745 1.00 1.00 1.00 12 934 0 0 0 0 0
RFA_00749 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00758 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00762 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00767 0.47 0.33 0.67 6 1882 3 0 3 0 12
RFA_00768 0.41 0.28 0.63 5 1883 3 0 3 0 13
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00781 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00786 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00791 0.83 0.75 0.92 24 5125 2 0 2 0 8
RFA_00792 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00801 0.80 0.72 0.88 23 5024 3 0 3 0 9
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10
RFA_00814 0.75 0.63 0.90 26 25171 4 0 3 1 15
RFA_00815 0.83 0.68 1.00 28 24503 1 0 0 1 13
RFA_00816 0.75 0.63 0.90 26 23191 4 0 3 1 15
RFA_00817 0.83 0.68 1.00 28 21917 1 0 0 1 13
RFA_00818 0.83 0.68 1.00 28 20273 1 0 0 1 13
RFA_00819 0.83 0.68 1.00 28 27938 0 0 0 0 13
RFA_00820 0.71 0.56 0.89 90 151424 13 3 8 2 70
RFA_00830 0.59 0.45 0.78 70 152538 23 3 17 3 84
SRP_00079 0.54 0.33 0.88 29 41872 6 0 4 2 59
SRP_00124 0.15 0.09 0.24 8 37094 27 3 23 1 77
SRP_00137 0.49 0.24 1.00 6 4180 0 0 0 0 19
SRP_00141 0.35 0.12 1.00 5 6323 1 0 0 1 36
SRP_00146 0.41 0.17 1.00 6 5247 0 0 0 0 30
SRP_00182 0.59 0.35 1.00 35 46021 1 0 0 1 66
SRP_00197 0.47 0.28 0.80 28 49420 8 0 7 1 73
SRP_00198 0.47 0.27 0.82 28 51006 7 0 6 1 75
SRP_00199 0.47 0.24 0.93 25 51013 3 0 2 1 80
SRP_00202 0.48 0.25 0.94 29 54254 2 0 2 0 88
SRP_00241 0.51 0.33 0.79 27 46022 9 0 7 2 55
SRP_00255 0.65 0.43 1.00 40 47546 2 0 0 2 54
SRP_00260 0.21 0.14 0.33 14 47852 29 1 28 0 86
SRP_00278 0.53 0.30 0.94 31 46023 3 0 2 1 74
SRP_00285 0.45 0.20 1.00 6 3735 0 0 0 0 24
SRP_00322 0.44 0.25 0.79 27 48482 8 0 7 1 82
SRP_00328 0.49 0.34 0.71 29 39580 16 1 11 4 56
SRP_00329 0.50 0.34 0.73 29 39863 16 0 11 5 56
SRP_00338 0.41 0.17 1.00 6 5454 0 0 0 0 30
SRP_00339 0.49 0.32 0.77 30 44512 9 0 9 0 64
SRP_00340 0.44 0.27 0.73 22 41298 12 0 8 4 60

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.