CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(seed)		PPfold(seed)
MCC	0.747	>	0.629
Average MCC ± 95% Confidence Intervals	0.768 ± 0.050	>	0.472 ± 0.096
Sensitivity	0.693	>	0.500
Positive Predictive Value	0.806	>	0.794
Total TP	1916	>	1382
Total TN	1171201	<	1171837
Total FP	722	>	501
Total FP CONTRA	79	>	54
Total FP INCONS	381	>	304
Total FP COMP	262	>	143
Total FN	849	<	1383
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and PPfold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and PPfold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and PPfold(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	1916
Total TN	1171201
Total FP	722
Total FP CONTRA	79
Total FP INCONS	381
Total FP COMP	262
Total FN	849

Total Scores
MCC	0.747
Average MCC ± 95% Confidence Intervals	0.768 ± 0.050
Sensitivity	0.693
Positive Predictive Value	0.806
Nr of predictions	62

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.97	0.94	1.00	17	2128	1	0	0	1	1
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	3	0	0	3	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	3	0	0	3	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	3	0	0	3	0
RFA_00626	rne5 links to Rfam database...	0.96	0.92	1.00	80	56536	7	0	0	7	7
RFA_00627	rne5 links to Rfam database...	0.96	0.93	1.00	81	56872	12	0	0	12	6
RFA_00628	rne5 links to Rfam database...	0.96	0.93	1.00	80	57211	12	0	0	12	6
RFA_00630	rne5 links to Rfam database...	0.92	0.87	0.97	76	56875	17	0	2	15	11
RFA_00654	Vimentin3 links to Rfam database...	0.34	0.28	0.42	5	2403	7	0	7	0	13
RFA_00658	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1122	3	0	2	1	10
RFA_00664	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	984	3	0	2	1	10
RFA_00708	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00749	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00764	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	3	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	3	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	2002	4	3	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1939	4	3	1	0	8
RFA_00805	RNAIII links to Rfam database...	0.64	0.49	0.84	73	133299	16	0	14	2	77
RFA_00808	RydC links to Rfam database...	0.71	0.56	0.90	9	2006	1	1	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	4	0	4	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	25161	5	0	0	5	2
RFA_00816	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	23181	6	0	0	6	2
RFA_00817	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	21906	4	0	0	4	2
RFA_00818	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	20262	3	0	0	3	2
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	6	0	0	6	2
SPR_00020	tRNA links to Rfam database...	1.00	1.00	1.00	20	2681	2	0	0	2	0
SPR_00137	tRNA links to Rfam database...	0.95	0.90	1.00	19	2907	3	0	0	3	2
SPR_00277	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	1	0	0	1	0
SPR_00394	tRNA links to Rfam database...	0.98	0.95	1.00	20	3635	2	0	0	2	1
SPR_00402	tRNA links to Rfam database...	0.98	0.95	1.00	20	2536	2	0	0	2	1
SPR_00721	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	1	0	0	1	0
SPR_00816	tRNA links to Rfam database...	1.00	1.00	1.00	20	3466	2	0	0	2	0
SPR_01157	tRNA links to Rfam database...	1.00	1.00	1.00	21	2754	1	0	0	1	0
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.74	0.64	0.88	21	5541	4	1	2	1	12
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.73	0.62	0.88	21	5754	4	1	2	1	13
SRP_00079	Plant_SRP links to Rfam database...	0.76	0.73	0.80	64	41825	30	0	16	14	24
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.73	0.62	0.88	21	5436	4	1	2	1	13
SRP_00099	Plant_SRP links to Rfam database...	0.62	0.62	0.63	59	44756	41	3	32	6	36
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.75	0.59	0.95	20	5544	5	0	1	4	14
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.68	0.74	58	37050	32	3	17	12	27
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.65	0.49	0.87	20	6305	5	1	2	2	21
SRP_00182	Plant_SRP links to Rfam database...	0.88	0.84	0.91	85	45963	17	0	8	9	16
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.73	0.62	0.88	21	5436	4	1	2	1	13
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.56	0.55	46	45972	53	9	29	15	36
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.66	0.63	59	49047	47	6	29	12	30
SRP_00253	Metazoa_SRP links to Rfam database...	0.65	0.66	0.64	59	49363	45	5	28	12	31
SRP_00257	Metazoa_SRP links to Rfam database...	0.53	0.48	0.58	52	50950	42	5	33	4	56
SRP_00260	Metazoa_SRP links to Rfam database...	0.55	0.53	0.58	53	47804	46	6	32	8	47
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.66	0.50	0.87	20	6763	5	1	2	2	20
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.71	0.55	0.91	21	6880	4	1	1	2	17
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.77	0.63	0.95	19	3721	4	0	1	3	11
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.59	0.64	50	39543	34	5	23	6	35
SRP_00329	Metazoa_SRP links to Rfam database...	0.75	0.72	0.78	61	39825	29	2	15	12	24
SRP_00331	Metazoa_SRP links to Rfam database...	0.65	0.61	0.69	53	37598	34	2	22	10	34
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.76	0.61	0.96	22	5437	3	0	1	2	14
SRP_00340	Metazoa_SRP links to Rfam database...	0.53	0.52	0.54	43	41249	51	6	30	15	39
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.42	0.35	0.50	11	4731	14	0	11	3	20
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.71	0.56	0.91	20	5334	5	1	1	3	16

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1382
Total TN	1171837
Total FP	501
Total FP CONTRA	54
Total FP INCONS	304
Total FP COMP	143
Total FN	1383

Total Scores
MCC	0.629
Average MCC ± 95% Confidence Intervals	0.472 ± 0.096
Sensitivity	0.500
Positive Predictive Value	0.794
Nr of predictions	62

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00277	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3655	0	0	0	0	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2556	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3486	0	0	0	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2775	0	0	0	0	21
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]