CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		Afold
MCC	0.685	>	0.638
Average MCC ± 95% Confidence Intervals	0.586 ± 0.107	<	0.627 ± 0.083
Sensitivity	0.581	<	0.642
Positive Predictive Value	0.808	>	0.636
Total TP	1096	<	1212
Total TN	803910	>	803359
Total FP	373	<	876
Total FP CONTRA	39	<	146
Total FP INCONS	221	<	549
Total FP COMP	113	<	181
Total FN	791	>	675
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PPfold(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and Afold).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1096
Total TN	803910
Total FP	373
Total FP CONTRA	39
Total FP INCONS	221
Total FP COMP	113
Total FN	791

Total Scores
MCC	0.685
Average MCC ± 95% Confidence Intervals	0.586 ± 0.107
Sensitivity	0.581
Positive Predictive Value	0.808
Nr of predictions	42

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	1212
Total TN	803359
Total FP	876
Total FP CONTRA	146
Total FP INCONS	549
Total FP COMP	181
Total FN	675

Total Scores
MCC	0.638
Average MCC ± 95% Confidence Intervals	0.627 ± 0.083
Sensitivity	0.642
Positive Predictive Value	0.636
Nr of predictions	42

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00627	rne5 links to Rfam database...	0.48	0.47	0.48	41	56868	50	10	34	6	46
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00654	Vimentin3 links to Rfam database...	0.27	0.28	0.28	5	2397	14	2	11	1	13
RFA_00658	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	1116	5	0	3	2	5
RFA_00664	Hammerhead_1 links to Rfam database...	0.07	0.07	0.09	1	979	11	0	10	1	13
RFA_00708	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	1027	3	0	3	0	9
RFA_00749	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00764	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	5	0	4	1	8
RFA_00768	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	8	1	6	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	10	3	5	2	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	12	1	10	1	10
RFA_00814	R2_retro_el links to Rfam database...	0.35	0.37	0.33	15	25155	42	7	23	12	26
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	32	0	1	31	2
SRP_00079	Plant_SRP links to Rfam database...	0.52	0.55	0.50	48	41809	53	8	40	5	40
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.81	0.82	0.80	28	5425	7	1	6	0	6
SRP_00099	Plant_SRP links to Rfam database...	0.57	0.57	0.57	54	44755	43	5	36	2	41
SRP_00105	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5532	33	4	29	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.53	0.52	0.55	44	37048	38	5	31	2	41
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.86	0.85	0.88	35	6288	5	1	4	0	6
SRP_00182	Plant_SRP links to Rfam database...	0.76	0.73	0.79	74	45962	21	3	17	1	27
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.46	0.47	0.46	16	5425	19	1	18	0	18
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.59	0.51	48	45961	50	11	36	3	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.62	0.64	0.59	57	49045	42	12	27	3	32
SRP_00253	Metazoa_SRP links to Rfam database...	0.61	0.63	0.59	57	49359	44	7	32	5	33
SRP_00257	Metazoa_SRP links to Rfam database...	0.85	0.87	0.84	94	50928	20	4	14	2	14
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.86	0.88	0.85	35	6745	8	1	5	2	5
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.91	0.92	0.90	35	6864	5	1	3	1	3
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.92	0.92	0.92	33	5424	4	0	3	1	3
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	47	9	36	2	34
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.93	0.92	0.94	33	5321	3	1	1	1	3

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]