CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RNAwolf
MCC	0.626	>	0.461
Average MCC ± 95% Confidence Intervals	0.464 ± 0.095	<	0.494 ± 0.067
Sensitivity	0.495	>	0.477
Positive Predictive Value	0.794	>	0.448
Total TP	1382	>	1333
Total TN	1177832	>	1176598
Total FP	501	<	2072
Total FP CONTRA	54	<	306
Total FP INCONS	304	<	1335
Total FP COMP	143	<	431
Total FN	1412	<	1461
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PPfold(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RNAwolf).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1382
Total TN	1177832
Total FP	501
Total FP CONTRA	54
Total FP INCONS	304
Total FP COMP	143
Total FN	1412

Total Scores
MCC	0.626
Average MCC ± 95% Confidence Intervals	0.464 ± 0.095
Sensitivity	0.495
Positive Predictive Value	0.794
Nr of predictions	63

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00277	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3655	0	0	0	0	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2556	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3486	0	0	0	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2775	0	0	0	0	21
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP	1333
Total TN	1176598
Total FP	2072
Total FP CONTRA	306
Total FP INCONS	1335
Total FP COMP	431
Total FN	1461

Total Scores
MCC	0.461
Average MCC ± 95% Confidence Intervals	0.494 ± 0.067
Sensitivity	0.477
Positive Predictive Value	0.448
Nr of predictions	63

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.70	0.78	0.64	14	2123	10	1	7	2	4
RFA_00390	Hammerhead_3 links to Rfam database...	0.74	0.67	0.83	10	1419	5	0	2	3	5
RFA_00416	Hammerhead_3 links to Rfam database...	0.80	0.80	0.80	12	1470	8	0	3	5	3
RFA_00433	Hammerhead_3 links to Rfam database...	0.71	0.67	0.77	10	1418	7	2	1	4	5
RFA_00626	rne5 links to Rfam database...	0.08	0.09	0.08	8	56511	99	24	73	2	79
RFA_00627	rne5 links to Rfam database...	0.38	0.39	0.37	34	56862	73	13	44	16	53
RFA_00628	rne5 links to Rfam database...	0.58	0.57	0.59	49	57208	64	7	27	30	37
RFA_00630	rne5 links to Rfam database...	0.48	0.47	0.49	41	56869	66	9	34	23	46
RFA_00654	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2394	21	3	18	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.56	0.50	0.64	7	1117	8	0	4	4	7
RFA_00664	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	974	16	0	16	0	14
RFA_00708	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1025	10	1	9	0	14
RFA_00749	s2m links to Rfam database...	0.55	0.58	0.54	7	890	9	1	5	3	5
RFA_00764	s2m links to Rfam database...	0.48	0.42	0.56	5	894	6	0	4	2	7
RFA_00765	s2m links to Rfam database...	0.36	0.42	0.33	5	888	13	0	10	3	7
RFA_00767	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	8	1	6	1	10
RFA_00768	Corona_pk3 links to Rfam database...	0.50	0.44	0.57	8	1877	8	1	5	2	10
RFA_00769	Corona_pk3 links to Rfam database...	0.41	0.44	0.38	8	1932	13	3	10	0	10
RFA_00770	Corona_pk3 links to Rfam database...	0.51	0.50	0.53	9	1999	12	2	6	4	9
RFA_00773	Corona_pk3 links to Rfam database...	0.42	0.39	0.47	7	1938	12	1	7	4	11
RFA_00779	Corona_pk3 links to Rfam database...	0.26	0.28	0.26	5	1934	14	6	8	0	13
RFA_00805	RNAIII links to Rfam database...	0.30	0.31	0.29	47	133225	121	13	101	7	103
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	2	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	6	0	4	2	10
RFA_00814	R2_retro_el links to Rfam database...	0.20	0.22	0.18	9	25149	62	12	30	20	32
RFA_00816	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	23162	66	17	41	8	41
RFA_00817	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	21892	57	12	41	4	41
RFA_00818	R2_retro_el links to Rfam database...	0.25	0.27	0.23	11	20253	51	12	25	14	30
RFA_00819	R2_retro_el links to Rfam database...	0.16	0.17	0.16	7	27921	70	6	32	32	34
SPR_00020	tRNA links to Rfam database...	0.31	0.35	0.28	7	2676	18	5	13	0	13
SPR_00137	tRNA links to Rfam database...	0.49	0.57	0.43	12	2898	18	7	9	2	9
SPR_00277	tRNA links to Rfam database...	0.30	0.33	0.28	7	2901	19	2	16	1	14
SPR_00394	tRNA links to Rfam database...	0.50	0.52	0.48	11	3632	16	6	6	4	10
SPR_00402	tRNA links to Rfam database...	0.73	0.76	0.70	16	2533	10	2	5	3	5
SPR_00721	tRNA links to Rfam database...	0.45	0.48	0.43	10	2903	14	0	13	1	11
SPR_00816	tRNA links to Rfam database...	0.95	0.95	0.95	19	3466	9	0	1	8	1
SPR_01157	tRNA links to Rfam database...	1.00	1.00	1.00	21	2754	4	0	0	4	0
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.91	31	5531	12	1	2	9	2
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.91	32	5743	12	1	2	9	2
SRP_00079	Plant_SRP links to Rfam database...	0.53	0.55	0.51	48	41811	63	9	37	17	40
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.75	0.76	0.74	26	5425	15	1	8	6	8
SRP_00099	Plant_SRP links to Rfam database...	0.55	0.57	0.53	54	44749	60	9	38	13	41
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.18	0.18	0.19	6	5533	26	3	23	0	28
SRP_00124	Metazoa_SRP links to Rfam database...	0.54	0.56	0.53	48	37037	55	8	35	12	37
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.71	0.76	0.67	22	5962	19	3	8	8	7
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.89	0.90	0.88	37	6286	11	1	4	6	4
SRP_00182	Plant_SRP links to Rfam database...	0.34	0.35	0.34	35	45952	72	13	56	3	66
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.64	0.65	0.65	22	5426	15	1	11	3	12
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.60	0.51	49	45959	61	14	34	13	33
SRP_00252	Metazoa_SRP links to Rfam database...	0.32	0.35	0.30	31	49039	79	12	59	8	58
SRP_00253	Metazoa_SRP links to Rfam database...	0.22	0.24	0.20	22	49346	89	14	73	2	68
SRP_00257	Metazoa_SRP links to Rfam database...	0.68	0.69	0.67	75	50928	49	5	32	12	33
SRP_00260	Metazoa_SRP links to Rfam database...	0.58	0.60	0.57	60	47790	58	8	37	13	40
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.85	0.83	0.87	33	6748	13	1	4	8	7
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.68	0.68	0.68	26	6865	17	0	12	5	12
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.61	0.53	0.70	16	3718	12	0	7	5	14
SRP_00328	Metazoa_SRP links to Rfam database...	0.32	0.33	0.31	28	39530	68	12	51	5	57
SRP_00329	Metazoa_SRP links to Rfam database...	0.31	0.33	0.30	28	39810	75	5	60	10	57
SRP_00331	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	53	37588	49	3	31	15	34
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	34	5424	9	0	2	7	2
SRP_00340	Metazoa_SRP links to Rfam database...	0.34	0.37	0.33	30	41236	75	10	52	13	52
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.43	0.45	0.41	14	4719	25	0	20	5	17
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	34	5320	8	1	1	6	2

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

2. Individual counts for RNAwolf [ download as .csv ]