CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		Vsfold4
MCC	0.635	>	0.244
Average MCC ± 95% Confidence Intervals	0.464 ± 0.097	>	0.321 ± 0.080
Sensitivity	0.511	>	0.225
Positive Predictive Value	0.790	>	0.268
Total TP	1350	>	594
Total TN	1044478	>	1043972
Total FP	501	<	1732
Total FP CONTRA	54	<	228
Total FP INCONS	304	<	1392
Total FP COMP	143	>	112
Total FN	1294	<	2050
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PPfold(seed) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and Vsfold4).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and Vsfold4).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and Vsfold4).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1350
Total TN	1044478
Total FP	501
Total FP CONTRA	54
Total FP INCONS	304
Total FP COMP	143
Total FN	1294

Total Scores
MCC	0.635
Average MCC ± 95% Confidence Intervals	0.464 ± 0.097
Sensitivity	0.511
Positive Predictive Value	0.790
Nr of predictions	62

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00277	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3655	0	0	0	0	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2556	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3486	0	0	0	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2775	0	0	0	0	21
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	594
Total TN	1043972
Total FP	1732
Total FP CONTRA	228
Total FP INCONS	1392
Total FP COMP	112
Total FN	2050

Total Scores
MCC	0.244
Average MCC ± 95% Confidence Intervals	0.321 ± 0.080
Sensitivity	0.225
Positive Predictive Value	0.268
Nr of predictions	62

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	-0.01	0.00	0.00	0	2133	12	0	12	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	0.93	0.87	1.00	13	1418	2	0	0	2	2
RFA_00416	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	3	0	0	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00626	rne5 links to Rfam database...	0.20	0.18	0.22	16	56543	61	11	46	4	71
RFA_00627	rne5 links to Rfam database...	0.23	0.22	0.24	19	56874	63	13	47	3	68
RFA_00628	rne5 links to Rfam database...	0.24	0.22	0.26	19	57218	64	8	46	10	67
RFA_00630	rne5 links to Rfam database...	0.30	0.29	0.32	25	56875	58	3	50	5	62
RFA_00654	Vimentin3 links to Rfam database...	0.54	0.44	0.67	8	2403	5	1	3	1	10
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	5	0	3	2	10
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00749	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00764	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00765	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00767	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1878	13	1	12	0	18
RFA_00768	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1875	16	1	15	0	18
RFA_00769	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	4	5	0	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	2003	15	2	11	2	18
RFA_00773	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1936	19	1	16	2	18
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	2	1	0	8
RFA_00808	RydC links to Rfam database...	0.62	0.56	0.69	9	2003	4	3	1	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.41	0.39	0.43	16	25163	33	3	18	12	25
RFA_00816	R2_retro_el links to Rfam database...	0.12	0.12	0.13	5	23181	42	9	25	8	36
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.11	5	21898	42	16	26	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20265	46	10	26	10	41
RFA_00819	R2_retro_el links to Rfam database...	0.20	0.20	0.21	8	27928	45	6	24	15	33
SPR_00020	tRNA links to Rfam database...	0.82	0.80	0.84	16	2682	4	1	2	1	4
SPR_00137	tRNA links to Rfam database...	0.83	0.81	0.85	17	2906	8	0	3	5	4
SPR_00277	tRNA links to Rfam database...	0.98	0.95	1.00	20	2906	0	0	0	0	1
SPR_00394	tRNA links to Rfam database...	0.75	0.71	0.79	15	3636	9	0	4	5	6
SPR_00402	tRNA links to Rfam database...	0.78	0.76	0.80	16	2536	5	0	4	1	5
SPR_00721	tRNA links to Rfam database...	0.68	0.67	0.70	14	2906	6	2	4	0	7
SPR_00816	tRNA links to Rfam database...	0.32	0.35	0.29	7	3462	20	5	12	3	13
SPR_01157	tRNA links to Rfam database...	0.98	0.95	1.00	20	2755	0	0	0	0	1
SRP_00020	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5537	28	3	25	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5748	30	3	27	0	34
SRP_00079	Plant_SRP links to Rfam database...	0.09	0.09	0.10	8	41827	71	4	66	1	80
SRP_00084	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5437	23	1	22	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.27	0.24	0.31	23	44776	51	7	44	0	72
SRP_00105	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5533	32	2	30	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.16	0.14	0.19	12	37066	50	5	45	0	73
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.16	0.17	0.16	5	5964	29	4	22	3	24
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.55	0.49	0.63	20	6296	12	2	10	0	21
SRP_00182	Plant_SRP links to Rfam database...	0.34	0.32	0.36	32	45968	56	10	46	0	69
SRP_00231	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5435	25	4	21	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.07	0.07	0.08	6	45978	74	13	59	2	76
SRP_00252	Metazoa_SRP links to Rfam database...	0.13	0.12	0.13	11	49058	75	11	61	3	78
SRP_00253	Metazoa_SRP links to Rfam database...	0.15	0.14	0.16	13	49376	68	7	59	2	77
SRP_00257	Metazoa_SRP links to Rfam database...	0.10	0.08	0.13	9	50971	60	1	59	0	99
SRP_00260	Metazoa_SRP links to Rfam database...	0.40	0.36	0.45	36	47815	44	4	40	0	64
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.40	0.38	0.44	15	6752	19	3	16	0	25
SRP_00274	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	6871	32	2	30	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	3719	22	2	20	0	30
SRP_00328	Metazoa_SRP links to Rfam database...	0.18	0.16	0.20	14	39550	57	11	46	0	71
SRP_00329	Metazoa_SRP links to Rfam database...	0.17	0.15	0.20	13	39839	51	5	46	0	72
SRP_00331	Metazoa_SRP links to Rfam database...	0.14	0.13	0.16	11	37608	56	5	51	0	76
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.24	0.22	0.28	8	5431	21	2	19	0	28
SRP_00340	Metazoa_SRP links to Rfam database...	0.18	0.17	0.19	14	41256	58	11	47	0	68
SRP_00341	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	4731	22	2	20	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5330	26	1	25	0	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]