CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of CMfinder(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & CMfinder(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) CMfinder(seed)
MCC 0.693 > 0.486
Average MCC ± 95% Confidence Intervals 0.574 ± 0.062 > 0.505 ± 0.044
Sensitivity 0.532 > 0.312
Positive Predictive Value 0.904 > 0.757
Total TP 3245 > 1905
Total TN 2880162 < 2881233
Total FP 487 < 688
Total FP CONTRA 31 < 40
Total FP INCONS 312 < 572
Total FP COMP 144 > 76
Total FN 2852 < 4192
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 3245
Total TN 2880162
Total FP 487
Total FP CONTRA 31
Total FP INCONS 312
Total FP COMP 144
Total FN 2852
Total Scores
MCC 0.693
Average MCC ± 95% Confidence Intervals 0.574 ± 0.062
Sensitivity 0.532
Positive Predictive Value 0.904
Nr of predictions 129

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.46 0.23 0.90 27 103710 3 0 3 0 88
CRW_00016 0.45 0.23 0.90 27 77391 3 0 3 0 93
CRW_00610 0.54 0.31 0.96 25 36289 3 0 1 2 56
CRW_00613 0.42 0.22 0.81 17 34959 6 0 4 2 61
CRW_00614 0.45 0.32 0.64 18 121743 11 2 8 1 39
CRW_00618 0.39 0.26 0.59 16 56253 11 2 9 0 45
CRW_00633 0.40 0.21 0.76 22 63517 7 2 5 0 84
CRW_00634 0.37 0.18 0.74 17 64597 12 0 6 6 77
CRW_00670 0.48 0.24 0.97 29 70095 1 0 1 0 91
CRW_00671 0.49 0.25 0.97 29 62805 1 0 1 0 88
CRW_00672 0.50 0.26 0.97 29 72360 1 0 1 0 82
CRW_00674 0.29 0.14 0.63 17 83409 10 6 4 0 107
CRW_00676 0.32 0.15 0.68 17 93503 13 0 8 5 98
CRW_00692 0.34 0.17 0.68 15 68613 13 0 7 6 75
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00012 0.65 0.43 1.00 3 403 0 0 0 0 4
PDB_00213 0.60 0.49 0.74 20 5023 7 0 7 0 21
PDB_00553 0.52 0.27 1.00 3 462 0 0 0 0 8
PDB_00716 0.60 0.43 0.83 10 2689 2 0 2 0 13
PDB_00810 0.84 0.71 1.00 12 1069 0 0 0 0 5
PDB_00827 0.35 0.21 0.59 17 26999 12 2 10 0 64
PDB_01050 0.55 0.31 1.00 4 626 1 0 0 1 9
PDB_01051 0.96 0.92 1.00 12 891 4 0 0 4 1
PDB_01092 0.70 0.54 0.90 28 10122 4 0 3 1 24
PDB_01152 0.80 0.71 0.91 10 550 1 0 1 0 4
RFA_00603 0.94 0.89 1.00 31 13499 0 0 0 0 4
RFA_00604 0.94 0.89 1.00 31 13499 0 0 0 0 4
RFA_00605 0.94 0.89 1.00 31 15194 0 0 0 0 4
RFA_00606 0.89 0.79 1.00 31 21290 0 0 0 0 8
RFA_00607 0.93 0.86 1.00 31 17735 0 0 0 0 5
RFA_00609 0.92 0.84 1.00 31 17924 0 0 0 0 6
RFA_00610 0.92 0.84 1.00 31 17174 0 0 0 0 6
RFA_00611 0.94 0.89 1.00 31 13010 0 0 0 0 4
RFA_00613 0.94 0.89 1.00 31 12849 0 0 0 0 4
RFA_00615 0.83 0.77 0.90 27 13336 3 0 3 0 8
RFA_00620 0.88 0.77 1.00 30 21915 0 0 0 0 9
RFA_00626 0.97 0.94 1.00 82 56534 6 0 0 6 5
RFA_00627 0.96 0.93 1.00 81 56872 7 0 0 7 6
RFA_00628 0.97 0.94 1.00 81 57210 6 0 0 6 5
RFA_00630 0.92 0.87 0.96 76 56874 12 0 3 9 11
RFA_00632 0.49 0.32 0.75 9 4083 3 2 1 0 19
RFA_00636 0.49 0.32 0.75 9 3993 3 2 1 0 19
RFA_00639 0.22 0.14 0.36 12 54582 21 4 17 0 75
RFA_00642 0.54 0.44 0.67 8 2914 4 0 4 0 10
RFA_00643 -0.01 0.00 0.00 0 2202 9 1 8 0 18
RFA_00644 0.44 0.33 0.60 6 2691 4 0 4 0 12
RFA_00645 -0.01 0.00 0.00 0 2406 9 1 8 0 18
RFA_00649 0.44 0.33 0.60 6 2135 4 0 4 0 12
RFA_00651 -0.01 0.00 0.00 0 2071 9 1 8 0 18
RFA_00653 0.42 0.33 0.55 6 2134 5 0 5 0 12
RFA_00654 0.52 0.44 0.62 8 2402 5 0 5 0 10
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00659 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00668 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00684 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00685 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00706 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00707 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00710 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00711 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00715 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00731 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00733 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00734 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00736 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00737 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00745 1.00 1.00 1.00 12 934 0 0 0 0 0
RFA_00749 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00758 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00762 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00769 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00770 0.65 0.56 0.77 10 2003 3 0 3 0 8
RFA_00773 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00781 0.68 0.63 0.74 20 5023 7 1 6 0 12
RFA_00786 0.68 0.63 0.74 20 5023 7 1 6 0 12
RFA_00791 0.68 0.63 0.74 20 5124 7 1 6 0 12
RFA_00792 0.68 0.63 0.74 20 5023 7 1 6 0 12
RFA_00801 0.68 0.63 0.74 20 5023 7 1 6 0 12
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10
RFA_00814 0.83 0.68 1.00 28 25172 0 0 0 0 13
RFA_00815 0.83 0.68 1.00 28 24503 0 0 0 0 13
RFA_00816 0.83 0.68 1.00 28 23192 0 0 0 0 13
RFA_00817 0.83 0.68 1.00 28 21917 0 0 0 0 13
RFA_00818 0.83 0.68 1.00 28 20273 0 0 0 0 13
RFA_00819 0.83 0.68 1.00 28 27938 0 0 0 0 13
SRP_00016 0.81 0.68 0.97 74 47819 5 0 2 3 35
SRP_00130 0.73 0.63 0.86 61 49699 17 0 10 7 36
SRP_00142 0.82 0.73 0.93 68 45983 10 0 5 5 25
SRP_00143 0.74 0.62 0.88 63 49698 17 0 9 8 38
SRP_00144 0.84 0.76 0.93 71 46589 9 0 5 4 23
SRP_00197 0.83 0.72 0.96 73 49379 8 0 3 5 28
SRP_00198 0.82 0.71 0.96 73 50964 8 0 3 5 30
SRP_00199 0.82 0.70 0.96 73 50964 8 0 3 5 32
SRP_00201 0.82 0.69 0.97 77 47816 3 0 2 1 34
SRP_00202 0.78 0.64 0.96 75 54207 4 0 3 1 42
SRP_00203 0.71 0.60 0.84 63 48753 15 0 12 3 42
SRP_00204 0.80 0.68 0.95 69 49068 11 0 4 7 33
SRP_00206 0.84 0.72 0.98 78 47815 3 0 2 1 30
SRP_00208 0.80 0.67 0.96 68 46594 11 0 3 8 33
SRP_00255 0.74 0.66 0.84 62 47512 18 0 12 6 32
SRP_00276 0.83 0.70 0.97 77 50642 3 0 2 1 33
SRP_00278 0.77 0.65 0.91 68 45981 9 0 7 2 37
SRP_00321 0.80 0.67 0.96 72 47511 5 1 2 2 36
SRP_00322 0.78 0.65 0.93 71 48440 7 0 5 2 38
SRP_00323 0.82 0.69 0.97 74 47202 4 0 2 2 33
SRP_00330 0.79 0.69 0.90 66 50013 13 0 7 6 29
SRP_00332 0.84 0.72 0.97 76 50325 3 0 2 1 30
SRP_00339 0.79 0.69 0.90 65 44479 10 0 7 3 29

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP 1905
Total TN 2881233
Total FP 688
Total FP CONTRA 40
Total FP INCONS 572
Total FP COMP 76
Total FN 4192
Total Scores
MCC 0.486
Average MCC ± 95% Confidence Intervals 0.505 ± 0.044
Sensitivity 0.312
Positive Predictive Value 0.757
Nr of predictions 129

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.37 0.14 1.00 16 103724 0 0 0 0 99
CRW_00016 0.36 0.14 0.89 17 77402 2 0 2 0 103
CRW_00610 0.49 0.31 0.78 25 36283 7 1 6 0 56
CRW_00613 0.54 0.33 0.87 26 34950 4 0 4 0 52
CRW_00614 0.46 0.25 0.88 14 121755 9 0 2 7 43
CRW_00618 0.36 0.13 1.00 8 56272 0 0 0 0 53
CRW_00633 0.32 0.12 0.81 13 63530 3 1 2 0 93
CRW_00634 0.40 0.17 0.94 16 64603 1 0 1 0 78
CRW_00670 0.32 0.18 0.55 22 70085 18 0 18 0 98
CRW_00671 0.20 0.09 0.41 11 62808 16 0 16 0 106
CRW_00672 0.38 0.15 0.94 17 72372 1 0 1 0 94
CRW_00674 0.40 0.17 0.95 21 83414 1 0 1 0 103
CRW_00676 0.12 0.04 0.33 5 93513 10 1 9 0 110
CRW_00692 0.41 0.17 1.00 15 68620 0 0 0 0 75
PDB_00005 0.47 0.36 0.63 5 938 3 0 3 0 9
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 0.00 0.00 0.00 0 465 0 0 0 0 11
PDB_00716 -0.01 0.00 0.00 0 2688 13 0 13 0 23
PDB_00810 0.76 0.59 1.00 10 1071 0 0 0 0 7
PDB_00827 0.25 0.10 0.62 8 27015 5 0 5 0 73
PDB_01050 0.68 0.46 1.00 6 624 1 0 0 1 7
PDB_01051 0.83 0.69 1.00 9 894 4 0 0 4 4
PDB_01092 0.38 0.21 0.69 11 10137 6 0 5 1 41
PDB_01152 0.92 0.86 1.00 12 549 0 0 0 0 2
RFA_00603 0.70 0.60 0.81 21 13504 7 0 5 2 14
RFA_00604 0.63 0.51 0.78 18 13507 8 0 5 3 17
RFA_00605 0.14 0.06 0.33 2 15219 5 0 4 1 33
RFA_00606 0.34 0.21 0.57 8 21307 8 2 4 2 31
RFA_00607 0.08 0.06 0.13 2 17750 15 3 11 1 34
RFA_00609 0.32 0.22 0.47 8 17938 12 2 7 3 29
RFA_00610 0.39 0.30 0.52 11 17184 13 2 8 3 26
RFA_00611 0.65 0.51 0.82 18 13019 5 0 4 1 17
RFA_00613 0.70 0.57 0.87 20 12857 4 0 3 1 15
RFA_00615 0.57 0.49 0.68 17 13341 10 0 8 2 18
RFA_00620 0.00 0.00 0.00 0 21939 6 0 6 0 39
RFA_00626 0.44 0.32 0.60 28 56569 22 2 17 3 59
RFA_00627 0.53 0.39 0.72 34 56906 15 3 10 2 53
RFA_00628 0.58 0.43 0.77 37 57243 14 3 8 3 49
RFA_00630 0.45 0.32 0.64 28 56909 17 3 13 1 59
RFA_00632 0.27 0.25 0.29 7 4071 17 0 17 0 21
RFA_00636 0.71 0.64 0.78 18 3982 5 2 3 0 10
RFA_00639 0.00 0.00 0.00 0 54575 44 6 34 4 87
RFA_00642 0.44 0.28 0.71 5 2919 2 0 2 0 13
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.00 0.00 0.00 0 2693 8 0 8 0 18
RFA_00645 0.29 0.17 0.50 3 2409 3 0 3 0 15
RFA_00649 0.35 0.22 0.57 4 2138 3 0 3 0 14
RFA_00651 0.35 0.22 0.57 4 2073 3 0 3 0 14
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.38 0.22 0.67 4 2409 2 0 2 0 14
RFA_00658 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00659 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00664 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00667 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00668 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00672 0.41 0.31 0.57 4 896 3 0 3 0 9
RFA_00673 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00674 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00675 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00677 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00704 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00705 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00709 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00710 0.32 0.21 0.50 3 984 3 0 3 0 11
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.30 0.14 0.67 2 943 2 0 1 1 12
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.30 0.21 0.43 3 896 4 0 4 0 11
RFA_00730 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00731 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00733 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00734 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00736 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00737 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00745 0.91 0.83 1.00 10 936 0 0 0 0 2
RFA_00749 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00758 0.86 0.75 1.00 9 894 0 0 0 0 3
RFA_00762 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00763 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00764 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00765 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00769 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00770 0.71 0.50 1.00 9 2007 0 0 0 0 9
RFA_00773 0.00 0.00 0.00 0 1949 4 0 4 0 18
RFA_00779 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00791 0.92 0.88 0.97 28 5122 1 0 1 0 4
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.41 0.38 0.46 6 2132 7 1 6 0 10
RFA_00814 0.68 0.51 0.91 21 25177 2 0 2 0 20
RFA_00815 0.68 0.51 0.91 21 24508 2 0 2 0 20
RFA_00816 0.68 0.51 0.91 21 23197 2 0 2 0 20
RFA_00817 0.68 0.56 0.82 23 21917 5 0 5 0 18
RFA_00818 0.60 0.49 0.74 20 20274 8 1 6 1 21
RFA_00819 0.62 0.51 0.75 21 27938 7 0 7 0 20
SRP_00016 0.54 0.35 0.83 38 47849 8 0 8 0 71
SRP_00130 0.50 0.32 0.78 31 49730 10 1 8 1 66
SRP_00142 0.46 0.37 0.58 34 45997 26 1 24 1 59
SRP_00143 0.50 0.30 0.86 30 49735 5 0 5 0 71
SRP_00144 0.54 0.37 0.80 35 46621 11 0 9 2 59
SRP_00197 0.46 0.26 0.84 26 49424 5 0 5 0 75
SRP_00198 0.56 0.37 0.84 38 50995 7 0 7 0 65
SRP_00199 0.54 0.35 0.82 37 50995 8 0 8 0 68
SRP_00201 0.54 0.35 0.83 39 47848 8 0 8 0 72
SRP_00202 0.43 0.21 0.86 25 54256 4 0 4 0 92
SRP_00203 0.51 0.34 0.77 36 48781 12 0 11 1 69
SRP_00204 0.52 0.34 0.80 35 49097 9 1 8 0 67
SRP_00206 0.55 0.36 0.83 39 47848 8 0 8 0 69
SRP_00208 0.52 0.33 0.83 33 46625 7 1 6 0 68
SRP_00255 0.49 0.27 0.89 25 47558 3 0 3 0 69
SRP_00276 0.51 0.33 0.80 36 50676 9 0 9 0 74
SRP_00278 0.52 0.33 0.81 35 46013 8 0 8 0 70
SRP_00321 0.42 0.21 0.82 23 47558 5 1 4 0 85
SRP_00322 0.52 0.33 0.82 36 48472 8 0 8 0 73
SRP_00323 0.54 0.34 0.88 36 47237 5 0 5 0 71
SRP_00330 0.44 0.23 0.85 22 50060 5 0 4 1 73
SRP_00332 0.44 0.25 0.75 27 50367 9 0 9 0 79
SRP_00339 0.56 0.39 0.79 37 44504 10 2 8 0 57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.