CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		PPfold(seed)
MCC	0.669	>	0.648
Average MCC ± 95% Confidence Intervals	0.641 ± 0.063	>	0.542 ± 0.097
Sensitivity	0.521	<	0.530
Positive Predictive Value	0.860	>	0.794
Total TP	1361	<	1382
Total TN	1151894	>	1151736
Total FP	326	<	501
Total FP CONTRA	27	<	54
Total FP INCONS	194	<	304
Total FP COMP	105	<	143
Total FN	1249	>	1228
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and PPfold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and PPfold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and PPfold(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	1361
Total TN	1151894
Total FP	326
Total FP CONTRA	27
Total FP INCONS	194
Total FP COMP	105
Total FN	1249

Total Scores
MCC	0.669
Average MCC ± 95% Confidence Intervals	0.641 ± 0.063
Sensitivity	0.521
Positive Predictive Value	0.860
Nr of predictions	54

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00390	Hammerhead_3 links to Rfam database...	0.93	0.87	1.00	13	1418	1	0	0	1	2
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.87	1.00	13	1472	1	0	0	1	2
RFA_00433	Hammerhead_3 links to Rfam database...	0.93	0.87	1.00	13	1418	1	0	0	1	2
RFA_00626	rne5 links to Rfam database...	0.97	0.94	1.00	82	56534	6	0	0	6	5
RFA_00627	rne5 links to Rfam database...	0.96	0.93	1.00	81	56872	7	0	0	7	6
RFA_00628	rne5 links to Rfam database...	0.97	0.94	1.00	81	57210	6	0	0	6	5
RFA_00630	rne5 links to Rfam database...	0.92	0.87	0.96	76	56874	12	0	3	9	11
RFA_00654	Vimentin3 links to Rfam database...	0.52	0.44	0.62	8	2402	5	0	5	0	10
RFA_00658	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1128	0	0	0	0	14
RFA_00664	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1035	0	0	0	0	14
RFA_00749	s2m links to Rfam database...	1.00	1.00	1.00	12	891	0	0	0	0	0
RFA_00764	s2m links to Rfam database...	1.00	1.00	1.00	12	891	0	0	0	0	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	0	0	0	0	0
RFA_00767	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1878	3	0	3	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1878	3	0	3	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	2003	3	0	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00805	RNAIII links to Rfam database...	0.50	0.37	0.69	55	133306	25	0	25	0	95
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	25172	0	0	0	0	13
RFA_00816	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	23192	0	0	0	0	13
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	0	0	0	0	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	0	0	0	0	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.52	0.27	1.00	9	5556	0	0	0	0	24
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.51	0.26	1.00	9	5769	0	0	0	0	25
SRP_00079	Plant_SRP links to Rfam database...	0.63	0.50	0.80	44	41850	15	0	11	4	44
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.51	0.26	1.00	9	5451	0	0	0	0	25
SRP_00099	Plant_SRP links to Rfam database...	0.68	0.51	0.92	48	44798	8	0	4	4	47
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.51	0.26	1.00	9	5556	0	0	0	0	25
SRP_00124	Metazoa_SRP links to Rfam database...	0.63	0.46	0.87	39	37083	15	2	4	9	46
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.70	0.62	0.78	18	5972	9	0	5	4	11
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.44	0.20	1.00	8	6320	1	0	0	1	33
SRP_00182	Plant_SRP links to Rfam database...	0.73	0.55	0.95	56	45997	4	0	3	1	45
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.51	0.26	1.00	9	5451	0	0	0	0	25
SRP_00241	Plant_SRP links to Rfam database...	0.59	0.48	0.72	39	46002	22	4	11	7	43
SRP_00252	Metazoa_SRP links to Rfam database...	0.56	0.49	0.64	44	49072	32	5	20	7	45
SRP_00253	Metazoa_SRP links to Rfam database...	0.57	0.49	0.68	44	49390	27	4	17	6	46
SRP_00257	Metazoa_SRP links to Rfam database...	0.55	0.40	0.77	43	50984	14	4	9	1	65
SRP_00260	Metazoa_SRP links to Rfam database...	0.54	0.44	0.66	44	47828	27	4	19	4	56
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.47	0.23	1.00	9	6777	0	0	0	0	31
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.49	0.24	1.00	9	6894	0	0	0	0	29
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.55	0.30	1.00	9	3732	0	0	0	0	21
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.48	0.85	41	39573	11	1	6	4	44
SRP_00329	Metazoa_SRP links to Rfam database...	0.66	0.51	0.86	43	39853	14	0	7	7	42
SRP_00331	Metazoa_SRP links to Rfam database...	0.58	0.47	0.72	41	37618	21	1	15	5	46
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.50	0.25	1.00	9	5451	0	0	0	0	27
SRP_00340	Metazoa_SRP links to Rfam database...	0.60	0.46	0.78	38	41279	20	2	9	9	44
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.51	0.26	1.00	8	4745	1	0	0	1	23
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.50	0.25	1.00	9	5347	0	0	0	0	27

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1382
Total TN	1151736
Total FP	501
Total FP CONTRA	54
Total FP INCONS	304
Total FP COMP	143
Total FN	1228

Total Scores
MCC	0.648
Average MCC ± 95% Confidence Intervals	0.542 ± 0.097
Sensitivity	0.530
Positive Predictive Value	0.794
Nr of predictions	54

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]