CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAshapes - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAshapes & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric RNAshapes Murlet(seed)
MCC 0.564 > 0.511
Average MCC ± 95% Confidence Intervals 0.557 ± 0.054 > 0.386 ± 0.066
Sensitivity 0.559 > 0.315
Positive Predictive Value 0.571 < 0.833
Total TP 2233 > 1257
Total TN 1448718 < 1451123
Total FP 2067 > 304
Total FP CONTRA 272 > 9
Total FP INCONS 1409 > 243
Total FP COMP 386 > 52
Total FN 1760 < 2736
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAshapes and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAshapes and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and Murlet(seed)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 2233
Total TN 1448718
Total FP 2067
Total FP CONTRA 272
Total FP INCONS 1409
Total FP COMP 386
Total FN 1760
Total Scores
MCC 0.564
Average MCC ± 95% Confidence Intervals 0.557 ± 0.054
Sensitivity 0.559
Positive Predictive Value 0.571
Nr of predictions 119

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.92 0.85 1.00 35 5015 0 0 0 0 6
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 -0.01 0.00 0.00 0 2678 24 1 22 1 23
PDB_00810 0.91 0.82 1.00 14 1067 0 0 0 0 3
PDB_01050 0.92 0.85 1.00 11 619 2 0 0 2 2
PDB_01051 0.96 0.92 1.00 12 891 4 0 0 4 1
PDB_01092 0.54 0.50 0.58 26 10108 21 2 17 2 26
PDB_01152 0.96 0.93 1.00 13 548 0 0 0 0 1
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00416 0.93 0.93 0.93 14 1470 4 0 1 3 1
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00587 1.00 1.00 1.00 15 4836 12 0 0 12 0
RFA_00603 0.70 0.74 0.67 26 13491 16 4 9 3 9
RFA_00604 0.73 0.71 0.76 25 13497 19 2 6 11 10
RFA_00605 0.32 0.34 0.30 12 15185 37 3 25 9 23
RFA_00606 0.67 0.67 0.67 26 21282 32 1 12 19 13
RFA_00607 0.84 0.83 0.86 30 17731 16 1 4 11 6
RFA_00609 0.76 0.78 0.74 29 17916 25 2 8 15 8
RFA_00610 0.57 0.57 0.57 21 17168 27 2 14 11 16
RFA_00611 0.62 0.66 0.59 23 13002 26 5 11 10 12
RFA_00613 0.64 0.63 0.65 22 12846 15 4 8 3 13
RFA_00615 0.66 0.69 0.63 24 13328 18 5 9 4 11
RFA_00620 0.44 0.46 0.42 18 21902 36 7 18 11 21
RFA_00626 0.45 0.45 0.46 39 56531 61 9 37 15 48
RFA_00627 0.63 0.61 0.66 53 56873 42 4 23 15 34
RFA_00628 0.82 0.80 0.84 69 57209 33 1 12 20 17
RFA_00632 0.34 0.36 0.33 10 4065 20 2 18 0 18
RFA_00636 0.42 0.43 0.43 12 3977 16 2 14 0 16
RFA_00639 0.22 0.24 0.21 21 54515 82 20 59 3 66
RFA_00642 0.24 0.22 0.27 4 2911 11 2 9 0 14
RFA_00643 0.24 0.22 0.27 4 2196 12 2 9 1 14
RFA_00644 -0.01 0.00 0.00 0 2681 20 4 16 0 18
RFA_00645 -0.01 0.00 0.00 0 2400 15 3 12 0 18
RFA_00649 0.22 0.22 0.22 4 2127 16 0 14 2 14
RFA_00651 0.35 0.33 0.38 6 2064 10 1 9 0 12
RFA_00653 0.33 0.33 0.33 6 2127 12 3 9 0 12
RFA_00654 0.27 0.28 0.28 5 2397 13 2 11 0 13
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00659 -0.01 0.00 0.00 0 1120 10 1 7 2 14
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 0.29 0.29 0.31 4 977 10 1 8 1 10
RFA_00668 0.41 0.43 0.40 6 975 9 0 9 0 8
RFA_00672 -0.01 0.00 0.00 0 895 9 0 8 1 13
RFA_00673 0.42 0.36 0.50 5 1118 6 0 5 1 9
RFA_00674 0.74 0.71 0.77 10 1115 4 0 3 1 4
RFA_00675 0.29 0.29 0.31 4 977 9 1 8 0 10
RFA_00677 0.42 0.43 0.43 6 976 9 0 8 1 8
RFA_00678 0.43 0.29 0.67 4 940 2 0 2 0 10
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00685 0.42 0.36 0.50 5 980 6 0 5 1 9
RFA_00695 0.51 0.43 0.60 6 7011 29 1 3 25 8
RFA_00703 0.67 0.64 0.69 9 4265 18 1 3 14 5
RFA_00704 -0.01 0.00 0.00 0 983 8 0 7 1 14
RFA_00705 0.74 0.71 0.77 10 1022 4 0 3 1 4
RFA_00706 0.37 0.29 0.50 4 1027 4 0 4 0 10
RFA_00707 -0.01 0.00 0.00 0 1026 9 3 6 0 14
RFA_00708 0.40 0.29 0.57 4 1028 3 0 3 0 10
RFA_00709 -0.01 0.00 0.00 0 982 9 0 8 1 14
RFA_00710 -0.01 0.00 0.00 0 981 9 0 9 0 14
RFA_00711 0.33 0.29 0.40 4 1025 6 0 6 0 10
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 935 11 0 11 0 14
RFA_00717 0.66 0.64 0.69 9 890 4 0 4 0 5
RFA_00730 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00731 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00733 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00734 0.64 0.67 0.62 8 890 5 1 4 0 4
RFA_00736 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00737 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00745 1.00 1.00 1.00 12 934 1 0 0 1 0
RFA_00749 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00758 0.96 0.92 1.00 11 892 0 0 0 0 1
RFA_00762 0.64 0.67 0.62 8 890 5 1 4 0 4
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00765 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00767 0.63 0.56 0.71 10 1877 4 0 4 0 8
RFA_00768 0.48 0.44 0.53 8 1876 7 1 6 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 0.61 0.56 0.67 10 2001 8 0 5 3 8
RFA_00773 0.71 0.56 0.91 10 1942 4 1 0 3 8
RFA_00779 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00781 0.73 0.75 0.71 24 5016 10 2 8 0 8
RFA_00786 0.23 0.22 0.26 7 5023 20 1 19 0 25
RFA_00791 0.46 0.47 0.45 15 5118 18 6 12 0 17
RFA_00792 0.94 0.94 0.94 30 5018 4 0 2 2 2
RFA_00801 0.85 0.81 0.90 26 5021 4 0 3 1 6
RFA_00808 -0.01 0.00 0.00 0 2001 15 2 13 0 16
RFA_00809 0.36 0.38 0.35 6 2128 11 1 10 0 10
RFA_00814 0.62 0.63 0.60 26 25157 26 6 11 9 15
RFA_00815 0.67 0.71 0.63 29 24485 31 1 16 14 12
RFA_00816 0.21 0.24 0.18 10 23164 47 18 28 1 31
RFA_00817 0.10 0.12 0.08 5 21881 60 21 38 1 36
RFA_00818 0.52 0.56 0.48 23 20253 31 9 16 6 18
RFA_00819 0.84 0.80 0.87 33 27928 36 0 5 31 8
SRP_00079 0.53 0.52 0.53 46 41819 52 1 39 12 42
SRP_00124 0.42 0.41 0.42 35 37045 51 5 43 3 50
SRP_00137 0.74 0.84 0.66 21 4154 13 4 7 2 4
SRP_00141 0.89 0.88 0.90 36 6288 5 1 3 1 5
SRP_00146 0.93 0.94 0.92 34 5216 3 1 2 0 2
SRP_00182 0.59 0.56 0.61 57 45963 37 5 31 1 44
SRP_00197 0.31 0.31 0.32 31 49358 67 4 62 1 70
SRP_00198 0.46 0.45 0.47 46 50943 56 3 48 5 57
SRP_00199 0.31 0.30 0.33 31 50945 67 3 61 3 74
SRP_00202 0.78 0.79 0.78 92 54167 30 3 23 4 25
SRP_00241 0.55 0.59 0.52 48 45963 47 13 32 2 34
SRP_00255 0.59 0.60 0.58 56 47489 47 2 39 6 38
SRP_00260 0.75 0.77 0.73 77 47789 31 6 23 2 23
SRP_00278 0.70 0.69 0.72 72 45956 30 3 25 2 33
SRP_00285 0.98 0.97 1.00 29 3712 0 0 0 0 1
SRP_00322 0.57 0.55 0.58 60 48413 44 3 40 1 49
SRP_00328 0.64 0.65 0.63 55 39533 38 8 25 5 30
SRP_00329 0.67 0.66 0.67 56 39820 28 4 23 1 29
SRP_00338 0.97 0.97 0.97 35 5424 1 0 1 0 1
SRP_00339 0.51 0.53 0.49 50 44449 54 8 44 2 44
SRP_00340 0.54 0.57 0.51 47 41236 47 9 36 2 35

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 1257
Total TN 1451123
Total FP 304
Total FP CONTRA 9
Total FP INCONS 243
Total FP COMP 52
Total FN 2736
Total Scores
MCC 0.511
Average MCC ± 95% Confidence Intervals 0.386 ± 0.066
Sensitivity 0.315
Positive Predictive Value 0.833
Nr of predictions 119

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00012 0.65 0.43 1.00 3 403 0 0 0 0 4
PDB_00213 0.73 0.59 0.92 24 5024 2 0 2 0 17
PDB_00553 0.45 0.27 0.75 3 461 1 0 1 0 8
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_00810 0.63 0.53 0.75 9 1069 3 0 3 0 8
PDB_01050 0.55 0.31 1.00 4 626 1 0 0 1 9
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
PDB_01152 0.76 0.64 0.90 9 551 1 0 1 0 5
RFA_00390 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00416 0.00 0.00 0.00 0 1485 0 0 0 0 15
RFA_00433 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00604 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00605 0.00 0.00 0.00 0 15225 0 0 0 0 35
RFA_00606 0.00 0.00 0.00 0 21321 0 0 0 0 39
RFA_00607 0.00 0.00 0.00 0 17766 0 0 0 0 36
RFA_00609 0.00 0.00 0.00 0 17955 0 0 0 0 37
RFA_00610 0.00 0.00 0.00 0 17205 0 0 0 0 37
RFA_00611 0.00 0.00 0.00 0 13041 0 0 0 0 35
RFA_00613 0.00 0.00 0.00 0 12880 0 0 0 0 35
RFA_00615 0.00 0.00 0.00 0 13366 0 0 0 0 35
RFA_00620 0.00 0.00 0.00 0 21945 0 0 0 0 39
RFA_00626 0.81 0.66 1.00 57 56559 4 0 0 4 30
RFA_00627 0.84 0.70 1.00 61 56892 5 0 0 5 26
RFA_00628 0.83 0.69 1.00 59 57232 8 0 0 8 27
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00639 0.21 0.11 0.40 10 54590 15 4 11 0 77
RFA_00642 0.57 0.44 0.73 8 2915 3 0 3 0 10
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.42 0.33 0.55 6 2690 5 0 5 0 12
RFA_00645 0.00 0.00 0.00 0 2407 8 0 8 0 18
RFA_00649 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00651 0.42 0.33 0.55 6 2069 5 0 5 0 12
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.57 0.44 0.73 8 2404 3 0 3 0 10
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00659 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00668 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00684 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00685 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00706 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00707 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00710 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00711 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00715 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00731 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00733 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00734 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00736 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00737 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00745 1.00 1.00 1.00 12 934 0 0 0 0 0
RFA_00749 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00758 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00762 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00767 0.47 0.33 0.67 6 1882 3 0 3 0 12
RFA_00768 0.41 0.28 0.63 5 1883 3 0 3 0 13
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00781 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00786 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00791 0.83 0.75 0.92 24 5125 2 0 2 0 8
RFA_00792 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00801 0.80 0.72 0.88 23 5024 3 0 3 0 9
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10
RFA_00814 0.75 0.63 0.90 26 25171 4 0 3 1 15
RFA_00815 0.83 0.68 1.00 28 24503 1 0 0 1 13
RFA_00816 0.75 0.63 0.90 26 23191 4 0 3 1 15
RFA_00817 0.83 0.68 1.00 28 21917 1 0 0 1 13
RFA_00818 0.83 0.68 1.00 28 20273 1 0 0 1 13
RFA_00819 0.83 0.68 1.00 28 27938 0 0 0 0 13
SRP_00079 0.54 0.33 0.88 29 41872 6 0 4 2 59
SRP_00124 0.15 0.09 0.24 8 37094 27 3 23 1 77
SRP_00137 0.49 0.24 1.00 6 4180 0 0 0 0 19
SRP_00141 0.35 0.12 1.00 5 6323 1 0 0 1 36
SRP_00146 0.41 0.17 1.00 6 5247 0 0 0 0 30
SRP_00182 0.59 0.35 1.00 35 46021 1 0 0 1 66
SRP_00197 0.47 0.28 0.80 28 49420 8 0 7 1 73
SRP_00198 0.47 0.27 0.82 28 51006 7 0 6 1 75
SRP_00199 0.47 0.24 0.93 25 51013 3 0 2 1 80
SRP_00202 0.48 0.25 0.94 29 54254 2 0 2 0 88
SRP_00241 0.51 0.33 0.79 27 46022 9 0 7 2 55
SRP_00255 0.65 0.43 1.00 40 47546 2 0 0 2 54
SRP_00260 0.21 0.14 0.33 14 47852 29 1 28 0 86
SRP_00278 0.53 0.30 0.94 31 46023 3 0 2 1 74
SRP_00285 0.45 0.20 1.00 6 3735 0 0 0 0 24
SRP_00322 0.44 0.25 0.79 27 48482 8 0 7 1 82
SRP_00328 0.49 0.34 0.71 29 39580 16 1 11 4 56
SRP_00329 0.50 0.34 0.73 29 39863 16 0 11 5 56
SRP_00338 0.41 0.17 1.00 6 5454 0 0 0 0 30
SRP_00339 0.49 0.32 0.77 30 44512 9 0 9 0 64
SRP_00340 0.44 0.27 0.73 22 41298 12 0 8 4 60

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.