CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAsubopt		PPfold(seed)
MCC	0.668	>	0.635
Average MCC ± 95% Confidence Intervals	0.664 ± 0.058	>	0.464 ± 0.097
Sensitivity	0.679	>	0.511
Positive Predictive Value	0.660	<	0.790
Total TP	1796	>	1350
Total TN	1043463	<	1044478
Total FP	1156	>	501
Total FP CONTRA	197	>	54
Total FP INCONS	730	>	304
Total FP COMP	229	>	143
Total FN	848	<	1294
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAsubopt and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and PPfold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and PPfold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and PPfold(seed)).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP	1796
Total TN	1043463
Total FP	1156
Total FP CONTRA	197
Total FP INCONS	730
Total FP COMP	229
Total FN	848

Total Scores
MCC	0.668
Average MCC ± 95% Confidence Intervals	0.664 ± 0.058
Sensitivity	0.679
Positive Predictive Value	0.660
Nr of predictions	62

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.52	0.56	0.50	10	2125	10	3	7	0	8
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.68	0.66	0.70	57	56535	42	6	18	18	30
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	33	4	14	15	28
RFA_00628	rne5 links to Rfam database...	0.89	0.86	0.91	74	57210	32	2	5	25	12
RFA_00630	rne5 links to Rfam database...	0.58	0.60	0.57	52	56861	51	12	28	11	35
RFA_00654	Vimentin3 links to Rfam database...	0.27	0.28	0.28	5	2397	13	2	11	0	13
RFA_00658	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	1118	5	0	3	2	7
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	3	0	3	0	10
RFA_00749	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00764	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	7	1	6	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.52	0.56	0.50	10	1933	10	4	6	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	2001	8	0	5	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	5	1	1	3	8
RFA_00779	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	18	2	13	3	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	11	1	10	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.39	0.39	0.39	16	25159	40	5	20	15	25
RFA_00816	R2_retro_el links to Rfam database...	0.74	0.78	0.70	32	23174	24	8	6	10	9
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	20247	39	13	19	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2
SPR_00020	tRNA links to Rfam database...	0.76	0.80	0.73	16	2679	8	2	4	2	4
SPR_00137	tRNA links to Rfam database...	0.84	0.86	0.82	18	2904	10	0	4	6	3
SPR_00277	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	0	0	0	0	0
SPR_00394	tRNA links to Rfam database...	0.49	0.52	0.46	11	3631	14	5	8	1	10
SPR_00402	tRNA links to Rfam database...	0.95	0.90	1.00	19	2537	2	0	0	2	2
SPR_00721	tRNA links to Rfam database...	0.48	0.52	0.44	11	2901	14	3	11	0	10
SPR_00816	tRNA links to Rfam database...	0.31	0.35	0.28	7	3461	21	5	13	3	13
SPR_01157	tRNA links to Rfam database...	0.73	0.76	0.70	16	2752	8	0	7	1	5
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.89	0.91	0.88	30	5531	4	1	3	0	3
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.87	0.88	0.86	30	5743	9	1	4	4	4
SRP_00079	Plant_SRP links to Rfam database...	0.71	0.73	0.70	64	41813	35	4	24	7	24
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.88	0.88	0.88	30	5426	4	1	3	0	4
SRP_00099	Plant_SRP links to Rfam database...	0.61	0.63	0.60	60	44750	42	7	33	2	35
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.53	0.53	0.53	18	5531	16	3	13	0	16
SRP_00124	Metazoa_SRP links to Rfam database...	0.67	0.67	0.68	57	37044	30	4	23	3	28
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.51	0.55	0.48	16	5962	23	3	14	6	13
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.89	0.88	0.90	36	6288	4	1	3	0	5
SRP_00182	Plant_SRP links to Rfam database...	0.70	0.68	0.71	69	45959	31	2	26	3	32
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.90	0.91	0.89	31	5425	4	1	3	0	3
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.52	48	45963	48	12	33	3	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.53	0.56	0.50	50	49041	53	13	37	3	39
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.67	0.61	60	49357	43	6	32	5	30
SRP_00257	Metazoa_SRP links to Rfam database...	0.80	0.81	0.79	87	50930	26	4	19	3	21
SRP_00260	Metazoa_SRP links to Rfam database...	0.64	0.69	0.60	69	47780	48	7	39	2	31
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.89	0.90	0.88	36	6745	7	1	4	2	4
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.93	0.95	0.92	36	6864	4	1	2	1	2
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.91	0.87	0.96	26	3714	1	0	1	0	4
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.66	0.63	56	39532	38	8	25	5	29
SRP_00329	Metazoa_SRP links to Rfam database...	0.61	0.62	0.60	53	39814	37	10	26	1	32
SRP_00331	Metazoa_SRP links to Rfam database...	0.55	0.55	0.55	48	37587	43	3	37	3	39
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.92	0.92	0.92	33	5424	3	0	3	0	3
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	48	8	37	3	34
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.77	0.77	0.77	24	4722	7	0	7	0	7
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.90	0.89	0.91	32	5321	4	1	2	1	4

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1350
Total TN	1044478
Total FP	501
Total FP CONTRA	54
Total FP INCONS	304
Total FP COMP	143
Total FN	1294

Total Scores
MCC	0.635
Average MCC ± 95% Confidence Intervals	0.464 ± 0.097
Sensitivity	0.511
Positive Predictive Value	0.790
Nr of predictions	62

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00277	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3655	0	0	0	0	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2556	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3486	0	0	0	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2775	0	0	0	0	21
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

2. Individual counts for RNAsubopt [ download as .csv ]

Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]