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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RSpredict(seed) NanoFolder
MCC 0.236 > 0.201
Average MCC ± 95% Confidence Intervals 0.221 ± 0.051 < 0.260 ± 0.039
Sensitivity 0.105 < 0.231
Positive Predictive Value 0.535 > 0.178
Total TP 939 < 2072
Total TN 4567550 > 4557657
Total FP 891 < 9850
Total FP CONTRA 77 < 1456
Total FP INCONS 740 < 8121
Total FP COMP 74 < 273
Total FN 8026 > 6893
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RSpredict(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and NanoFolder).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 939
Total TN 4567550
Total FP 891
Total FP CONTRA 77
Total FP INCONS 740
Total FP COMP 74
Total FN 8026
Total Scores
MCC 0.236
Average MCC ± 95% Confidence Intervals 0.221 ± 0.051
Sensitivity 0.105
Positive Predictive Value 0.535
Nr of predictions 121

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.00 0.00 0.00 0 51038 2 0 2 0 64
ASE_00083 0.00 0.00 0.00 0 62477 5 0 4 1 110
ASE_00122 0.00 0.00 0.00 0 43360 6 0 5 1 88
ASE_00185 0.00 0.00 0.00 0 73531 5 0 5 0 128
ASE_00190 0.00 0.00 0.00 0 45437 15 3 11 1 90
ASE_00191 0.00 0.00 0.00 0 29646 0 0 0 0 61
ASE_00196 0.00 0.00 0.00 0 31626 0 0 0 0 75
ASE_00221 0.00 0.00 0.00 0 64617 3 0 3 0 117
ASE_00227 0.00 0.00 0.00 0 78993 10 3 7 0 133
ASE_00228 0.00 0.00 0.00 0 46967 4 0 4 0 86
ASE_00229 0.00 0.00 0.00 0 42482 4 1 3 0 87
ASE_00231 0.07 0.02 0.22 2 47886 8 2 5 1 94
ASE_00234 0.00 0.00 0.00 0 75463 3 1 2 0 129
ASE_00238 0.07 0.01 0.50 1 64259 1 0 1 0 113
ASE_00248 0.11 0.03 0.43 3 62474 4 0 4 0 111
ASE_00250 0.08 0.02 0.30 3 78993 7 0 7 0 128
ASE_00254 0.00 0.00 0.00 0 36850 6 1 5 0 82
ASE_00255 0.12 0.03 0.50 4 74683 4 0 4 0 126
ASE_00257 0.00 0.00 0.00 0 51035 5 0 5 0 97
ASE_00267 0.00 0.00 0.00 0 45145 6 0 5 1 88
ASE_00270 0.00 0.00 0.00 0 72388 3 0 2 1 128
ASE_00274 0.00 0.00 0.00 0 55608 3 0 3 0 103
ASE_00277 0.00 0.00 0.00 0 48203 2 0 2 0 91
ASE_00279 0.00 0.00 0.00 0 53299 2 0 2 0 101
ASE_00285 0.00 0.00 0.00 0 69000 6 0 6 0 122
ASE_00287 0.00 0.00 0.00 0 54939 7 0 7 0 103
ASE_00294 0.08 0.02 0.31 4 114468 9 0 9 0 167
ASE_00295 0.00 0.00 0.00 0 73909 11 0 11 0 131
ASE_00298 0.00 0.00 0.00 0 67525 3 1 2 0 113
ASE_00318 0.00 0.00 0.00 0 80184 21 0 16 5 118
ASE_00321 0.00 0.00 0.00 0 54597 21 1 17 3 88
ASE_00335 0.00 0.00 0.00 0 75451 19 1 14 4 116
ASE_00339 0.00 0.00 0.00 0 80192 8 0 8 0 119
ASE_00340 0.04 0.01 0.14 1 46049 6 0 6 0 84
ASE_00343 0.00 0.00 0.00 0 83429 8 1 6 1 113
ASE_00367 0.00 0.00 0.00 0 43067 5 0 4 1 86
ASE_00370 0.10 0.02 0.40 2 41900 3 0 3 0 82
ASE_00372 0.00 0.00 0.00 0 51997 6 0 6 0 100
ASE_00375 0.00 0.00 0.00 0 60373 5 0 5 0 110
ASE_00376 0.04 0.01 0.17 1 56947 5 0 5 0 104
ASE_00377 0.00 0.00 0.00 0 57628 2 0 2 0 107
ASE_00386 0.10 0.03 0.33 3 50394 7 0 6 1 93
ASE_00393 0.00 0.00 0.00 0 47891 4 0 4 0 93
ASE_00412 0.04 0.01 0.17 1 58305 5 1 4 0 104
ASE_00413 0.00 0.00 0.00 0 44546 5 0 5 0 81
ASE_00416 0.00 0.00 0.00 0 77412 9 0 9 0 127
ASE_00417 0.00 0.00 0.00 0 54615 0 0 0 0 100
ASE_00422 0.05 0.02 0.12 2 46954 19 1 14 4 92
ASE_00427 0.00 0.00 0.00 0 40755 0 0 0 0 46
ASE_00428 0.00 0.00 0.00 0 76629 8 0 7 1 125
ASE_00430 0.07 0.02 0.25 2 46963 6 0 6 0 95
ASE_00434 0.04 0.02 0.11 2 68246 20 1 16 3 108
ASE_00437 0.00 0.00 0.00 0 79395 7 0 6 1 135
ASE_00451 0.11 0.03 0.36 4 70865 7 0 7 0 121
ASE_00454 0.00 0.00 0.00 0 43365 0 0 0 0 63
CRW_00671 0.00 0.00 0.00 0 62835 0 0 0 0 117
CRW_00672 0.00 0.00 0.00 0 72386 7 0 4 3 111
CRW_00674 0.00 0.00 0.00 0 83436 1 0 0 1 124
CRW_00676 0.00 0.00 0.00 0 93527 2 0 1 1 115
PDB_00828 0.54 0.41 0.73 11 2470 4 2 2 0 16
PDB_01051 -0.01 0.00 0.00 0 899 4 2 2 0 13
PDB_01236 0.00 0.00 0.00 0 11621 7 0 7 0 54
RFA_00416 0.63 0.40 1.00 6 1479 1 0 0 1 9
RFA_00434 0.63 0.40 1.00 6 1425 1 0 0 1 9
RFA_00436 0.63 0.40 1.00 6 1425 1 0 0 1 9
RFA_00442 0.63 0.40 1.00 6 1425 1 0 0 1 9
RFA_00446 -0.01 0.00 0.00 0 1481 4 0 4 0 15
RFA_00604 0.00 0.00 0.00 0 13529 1 0 1 0 35
RFA_00620 0.00 0.00 0.00 0 21941 4 0 4 0 39
RFA_00664 0.59 0.50 0.70 7 980 4 0 3 1 7
RFA_00674 0.69 0.64 0.75 9 1116 4 0 3 1 5
RFA_00675 0.62 0.50 0.78 7 981 3 0 2 1 7
RFA_00677 0.72 0.64 0.82 9 979 2 0 2 0 5
RFA_00684 0.80 0.64 1.00 9 981 1 0 0 1 5
RFA_00703 0.54 0.36 0.83 5 4272 1 0 1 0 9
RFA_00716 0.56 0.43 0.75 6 938 3 0 2 1 8
RFA_00717 0.50 0.36 0.71 5 896 2 0 2 0 9
RFA_00730 0.91 0.83 1.00 10 893 1 0 0 1 2
RFA_00763 0.91 0.83 1.00 10 893 1 0 0 1 2
RFA_00765 0.91 0.83 1.00 10 893 1 0 0 1 2
RFA_00770 0.54 0.56 0.53 10 1997 9 6 3 0 8
RFA_00773 0.50 0.50 0.50 9 1935 9 6 3 0 9
RFA_00808 0.60 0.50 0.73 8 2005 4 0 3 1 8
RFA_00816 0.90 0.85 0.95 35 23183 8 0 2 6 6
SRP_00038 0.35 0.21 0.58 7 5038 5 1 4 0 26
SRP_00046 0.33 0.19 0.60 6 4743 4 1 3 0 26
SRP_00103 0.56 0.42 0.74 43 45393 15 0 15 0 59
SRP_00117 0.57 0.39 0.83 40 45403 9 0 8 1 62
SRP_00144 0.55 0.43 0.70 40 46608 20 1 16 3 54
SRP_00170 0.00 0.00 0.00 0 4091 4 0 4 0 25
SRP_00173 0.53 0.44 0.63 40 38163 25 4 19 2 50
SRP_00194 0.16 0.10 0.29 2 3233 5 2 3 0 19
SRP_00197 0.51 0.37 0.73 37 49404 15 3 11 1 64
SRP_00198 0.52 0.39 0.70 40 50983 20 2 15 3 63
SRP_00200 0.00 0.00 0.00 0 6888 15 1 14 0 36
SRP_00216 0.00 0.00 0.00 0 3396 7 1 6 0 27
SRP_00229 0.00 0.00 0.00 0 5246 7 2 5 0 27
SRP_00233 0.00 0.00 0.00 0 5141 10 1 9 0 33
SRP_00234 0.59 0.53 0.66 46 36245 27 5 19 3 40
SRP_00243 0.00 0.00 0.00 0 5140 11 1 10 0 31
SRP_00244 0.00 0.00 0.00 0 6891 12 1 11 0 39
SRP_00266 0.00 0.00 0.00 0 4647 9 1 8 0 29
SRP_00267 0.17 0.11 0.26 11 44509 32 0 31 1 85
SRP_00269 0.29 0.18 0.46 6 5037 7 0 7 0 27
SRP_00273 0.00 0.00 0.00 0 6778 8 1 7 0 40
SRP_00276 0.62 0.48 0.79 53 50654 15 1 13 1 57
SRP_00278 0.48 0.35 0.65 37 45999 21 1 19 1 68
SRP_00285 0.33 0.20 0.55 6 3730 5 0 5 0 24
SRP_00303 0.00 0.00 0.00 0 6665 5 1 4 0 32
SRP_00308 0.62 0.55 0.72 48 36248 19 4 15 0 40
SRP_00317 0.47 0.36 0.63 35 45094 21 0 21 0 63
SRP_00321 0.37 0.25 0.56 27 47538 22 1 20 1 81
SRP_00322 0.47 0.34 0.66 37 48460 20 2 17 1 72
SRP_00332 0.70 0.58 0.86 61 50332 11 0 10 1 45
SRP_00333 0.33 0.21 0.54 7 5138 6 0 6 0 27
SRP_00337 0.58 0.49 0.68 45 35445 21 4 17 0 46
SRP_00338 0.51 0.33 0.80 12 5445 4 0 3 1 24
SRP_00342 0.38 0.24 0.60 6 3995 4 0 4 0 19
SRP_00358 0.49 0.29 0.83 10 6316 2 1 1 0 25
SRP_00383 0.54 0.42 0.71 10 3226 4 0 4 0 14
TMR_00357 0.25 0.09 0.73 8 83017 3 0 3 0 84

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 2072
Total TN 4557657
Total FP 9850
Total FP CONTRA 1456
Total FP INCONS 8121
Total FP COMP 273
Total FN 6893
Total Scores
MCC 0.201
Average MCC ± 95% Confidence Intervals 0.260 ± 0.039
Sensitivity 0.231
Positive Predictive Value 0.178
Nr of predictions 121

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00017 0.02 0.03 0.02 2 50914 131 38 86 7 62
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00122 0.27 0.30 0.24 26 43258 84 13 68 3 62
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00191 0.36 0.43 0.30 26 29559 67 15 46 6 35
ASE_00196 0.49 0.57 0.42 43 31524 62 16 43 3 32
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00227 0.28 0.31 0.25 41 78840 122 20 102 0 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00231 0.37 0.42 0.33 40 47773 84 17 65 2 56
ASE_00234 0.25 0.27 0.23 35 75315 117 10 106 1 94
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00248 0.13 0.15 0.12 17 62340 124 9 115 0 97
ASE_00250 0.25 0.29 0.23 38 78835 135 17 113 5 93
ASE_00254 0.15 0.16 0.14 13 36761 88 3 79 6 69
ASE_00255 0.11 0.12 0.10 16 74530 146 16 129 1 114
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00274 0.00 0.00 0.00 0 55487 126 12 112 2 103
ASE_00277 0.10 0.12 0.08 11 48071 123 23 100 0 80
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00287 0.15 0.17 0.14 17 54824 107 14 91 2 86
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00295 0.14 0.16 0.13 21 73761 140 19 119 2 110
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00318 0.03 0.04 0.03 5 80039 156 21 135 0 113
ASE_00321 0.11 0.14 0.09 12 54484 122 22 97 3 76
ASE_00335 0.10 0.12 0.09 14 75304 151 22 126 3 102
ASE_00339 0.25 0.29 0.22 34 80042 129 20 104 5 85
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00343 0.14 0.17 0.12 19 83275 145 31 111 3 94
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00370 0.03 0.04 0.03 3 41796 109 18 88 3 81
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00375 0.12 0.14 0.11 15 60246 120 10 107 3 95
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00377 0.25 0.27 0.23 29 57505 98 10 86 2 78
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00413 0.08 0.10 0.07 8 44438 108 19 86 3 73
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00417 0.32 0.36 0.28 36 54486 98 18 75 5 64
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00427 0.06 0.09 0.04 4 40651 105 35 65 5 42
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00434 0.29 0.34 0.25 37 68116 122 20 92 10 73
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
ASE_00454 0.24 0.32 0.19 20 43260 103 28 57 18 43
CRW_00671 0.18 0.21 0.16 24 62682 130 23 106 1 93
CRW_00672 0.36 0.43 0.31 48 72233 114 35 74 5 63
CRW_00674 0.16 0.19 0.14 23 83274 142 19 120 3 101
CRW_00676 0.11 0.14 0.09 16 93347 169 29 136 4 99
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_01051 -0.02 0.00 0.00 0 885 18 1 17 0 13
PDB_01236 0.31 0.33 0.30 18 11568 43 3 39 1 36
RFA_00416 0.94 1.00 0.88 15 1468 6 2 0 4 0
RFA_00434 0.84 1.00 0.71 15 1410 8 6 0 2 0
RFA_00436 0.86 1.00 0.75 15 1411 7 5 0 2 0
RFA_00442 0.94 1.00 0.88 15 1414 4 2 0 2 0
RFA_00446 0.85 0.93 0.78 14 1467 7 3 1 3 1
RFA_00604 0.42 0.54 0.33 19 13472 53 14 25 14 16
RFA_00620 0.16 0.23 0.11 9 21864 80 29 43 8 30
RFA_00664 -0.01 0.00 0.00 0 978 13 0 12 1 14
RFA_00674 0.12 0.14 0.13 2 1112 15 0 14 1 12
RFA_00675 0.28 0.29 0.29 4 976 10 1 9 0 10
RFA_00677 0.62 0.64 0.60 9 975 10 0 6 4 5
RFA_00684 0.74 0.71 0.77 10 977 5 2 1 2 4
RFA_00703 0.26 0.36 0.19 5 4252 32 5 16 11 9
RFA_00716 -0.02 0.00 0.00 0 929 17 0 17 0 14
RFA_00717 0.64 0.64 0.64 9 889 5 2 3 0 5
RFA_00730 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00763 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00765 0.39 0.42 0.38 5 890 9 2 6 1 7
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0
RFA_00816 0.00 0.00 0.00 0 23133 89 30 57 2 41
SRP_00038 0.23 0.27 0.20 9 5005 36 1 35 0 24
SRP_00046 0.33 0.38 0.29 12 4712 30 3 26 1 20
SRP_00103 0.00 0.00 0.00 0 45319 132 14 118 0 102
SRP_00117 0.20 0.23 0.18 23 45322 106 9 97 0 79
SRP_00144 0.05 0.06 0.05 6 46538 122 17 104 1 88
SRP_00170 0.29 0.36 0.25 9 4059 28 4 23 1 16
SRP_00173 0.00 0.00 0.00 0 38104 124 13 109 2 90
SRP_00194 0.27 0.33 0.23 7 3209 27 5 19 3 14
SRP_00197 0.12 0.14 0.11 14 49324 117 16 101 0 87
SRP_00198 0.07 0.08 0.06 8 50903 129 15 114 0 95
SRP_00200 0.41 0.47 0.35 17 6855 31 4 27 0 19
SRP_00216 0.44 0.48 0.41 13 3371 19 4 15 0 14
SRP_00229 0.42 0.52 0.35 14 5213 26 8 18 0 13
SRP_00233 0.25 0.30 0.22 10 5106 35 4 31 0 23
SRP_00234 0.21 0.24 0.18 21 36200 97 19 75 3 65
SRP_00243 0.47 0.55 0.40 17 5109 25 7 18 0 14
SRP_00244 0.38 0.44 0.34 17 6853 33 2 31 0 22
SRP_00266 0.55 0.66 0.46 19 4615 22 8 14 0 10
SRP_00267 0.04 0.05 0.04 5 44424 122 15 107 0 91
SRP_00269 0.46 0.52 0.43 17 5010 24 6 17 1 16
SRP_00273 0.36 0.40 0.33 16 6737 34 6 27 1 24
SRP_00276 0.19 0.22 0.18 24 50585 112 10 102 0 86
SRP_00278 0.33 0.36 0.30 38 45928 90 14 76 0 67
SRP_00285 0.38 0.43 0.35 13 3704 24 6 18 0 17
SRP_00303 0.36 0.41 0.33 13 6630 27 3 24 0 19
SRP_00308 0.14 0.17 0.12 15 36189 112 18 93 1 73
SRP_00317 0.14 0.16 0.12 16 45018 116 16 100 0 82
SRP_00321 0.44 0.49 0.40 53 47453 81 16 64 1 55
SRP_00322 0.22 0.25 0.21 27 48385 105 8 96 1 82
SRP_00332 0.12 0.14 0.11 15 50269 120 8 111 1 91
SRP_00333 0.20 0.24 0.19 8 5108 35 3 32 0 26
SRP_00337 0.42 0.46 0.38 42 35400 70 15 54 1 49
SRP_00338 0.52 0.56 0.49 20 5419 22 4 17 1 16
SRP_00342 0.20 0.24 0.17 6 3970 29 7 22 0 19
SRP_00358 0.32 0.37 0.28 13 6282 33 4 29 0 22
SRP_00383 -0.01 0.00 0.00 0 3205 35 9 26 0 24
TMR_00357 0.26 0.34 0.19 31 82869 146 44 84 18 61

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.