CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	TurboFold(seed)		Sfold
MCC	0.791	>	0.690
Average MCC ± 95% Confidence Intervals	0.783 ± 0.059	>	0.676 ± 0.075
Sensitivity	0.762	>	0.665
Positive Predictive Value	0.822	>	0.718
Total TP	1598	>	1394
Total TN	900807	<	900810
Total FP	543	<	721
Total FP CONTRA	62	<	125
Total FP INCONS	285	<	423
Total FP COMP	196	>	173
Total FN	499	<	703
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of TurboFold(seed) and Sfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and Sfold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and Sfold).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and Sfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and Sfold).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP	1598
Total TN	900807
Total FP	543
Total FP CONTRA	62
Total FP INCONS	285
Total FP COMP	196
Total FN	499

Total Scores
MCC	0.791
Average MCC ± 95% Confidence Intervals	0.783 ± 0.059
Sensitivity	0.762
Positive Predictive Value	0.822
Nr of predictions	51

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
CRW_01535	5S_rRNA links to Rfam database...	0.94	0.89	1.00	33	7107	3	0	0	3	4
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	2	0	0	2	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00587	Y_RNA links to Rfam database...	1.00	1.00	1.00	15	4836	11	0	0	11	0
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00654	Vimentin3 links to Rfam database...	0.44	0.33	0.60	6	2405	5	1	3	1	12
RFA_00658	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	1118	5	0	3	2	7
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00703	Hammerhead_1 links to Rfam database...	0.67	0.64	0.69	9	4265	18	1	3	14	5
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	3	0	3	0	10
RFA_00749	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00764	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	5	0	2	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	2	1	0	1	8
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	0	1	0	8
RFA_00805	RNAIII links to Rfam database...	0.87	0.82	0.93	123	133254	13	0	9	4	27
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.38	0.38	0.40	6	2130	9	1	8	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.88	0.88	0.88	30	5426	4	1	3	0	4
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.61	0.66	0.58	19	5962	18	3	11	4	10
SRP_00137	Bacteria_small_SRP links to Rfam database...	0.75	0.84	0.68	21	4155	10	4	6	0	4
SRP_00146	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5216	3	1	2	0	2
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.90	0.92	0.89	33	6866	4	1	3	0	3
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.91	0.91	0.91	31	5426	3	1	2	0	3
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.95	0.93	0.97	28	3712	1	0	1	0	2
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	34	5424	2	0	2	0	2
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5319	3	1	2	0	2
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	33	6750	3	1	2	0	2

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Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP	1394
Total TN	900810
Total FP	721
Total FP CONTRA	125
Total FP INCONS	423
Total FP COMP	173
Total FN	703

Total Scores
MCC	0.690
Average MCC ± 95% Confidence Intervals	0.676 ± 0.075
Sensitivity	0.665
Positive Predictive Value	0.718
Nr of predictions	51

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.59	0.60	0.59	39	27195	27	6	21	0	26
CRW_01535	5S_rRNA links to Rfam database...	0.84	0.78	0.91	29	7108	7	0	3	4	8
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00587	Y_RNA links to Rfam database...	1.00	1.00	1.00	15	4836	8	0	0	8	0
RFA_00626	rne5 links to Rfam database...	0.89	0.84	0.95	73	56539	20	1	3	16	14
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	30	4	14	12	28
RFA_00628	rne5 links to Rfam database...	0.90	0.86	0.95	74	57213	28	0	4	24	12
RFA_00630	rne5 links to Rfam database...	0.61	0.59	0.65	51	56874	38	7	21	10	36
RFA_00636	HDV_ribozyme links to Rfam database...	0.40	0.39	0.41	11	3978	16	2	14	0	17
RFA_00654	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2401	14	2	12	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	1118	5	0	3	2	7
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00703	Hammerhead_1 links to Rfam database...	0.67	0.64	0.69	9	4265	16	1	3	12	5
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	3	0	3	0	10
RFA_00749	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00764	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	7	1	6	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.52	0.56	0.50	10	1933	10	4	6	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	5	0	2	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.57	0.56	0.59	10	1936	7	1	6	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	0	2	0	8
RFA_00805	RNAIII links to Rfam database...	0.66	0.55	0.80	83	133282	25	1	20	4	67
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2000	19	2	14	3	16
RFA_00809	RydC links to Rfam database...	0.37	0.38	0.38	6	2129	10	1	9	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	25168	10	0	1	9	10
RFA_00816	R2_retro_el links to Rfam database...	0.76	0.73	0.79	30	23182	12	8	0	4	11
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.11	5	21899	41	14	27	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.31	0.22	0.43	9	20280	13	8	4	1	32
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.80	0.97	33	27932	25	0	1	24	8
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.85	0.85	0.85	29	5426	5	1	4	0	5
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.52	0.55	0.50	16	5963	21	3	13	5	13
SRP_00137	Bacteria_small_SRP links to Rfam database...	0.74	0.84	0.66	21	4154	11	4	7	0	4
SRP_00146	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5216	3	1	2	0	2
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.82	0.83	0.81	30	6866	8	1	6	1	6
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.89	0.88	0.91	30	5427	3	1	2	0	4
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.57	0.53	47	45967	44	11	31	2	35
SRP_00257	Metazoa_SRP links to Rfam database...	0.84	0.83	0.84	90	50933	19	4	13	2	18
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.89	0.83	0.96	25	3715	1	0	1	0	5
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.62	0.59	0.65	52	36235	30	8	20	2	36
SRP_00328	Metazoa_SRP links to Rfam database...	0.63	0.64	0.64	54	39536	34	7	24	3	31
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.71	0.73	60	39821	25	3	19	3	25
SRP_00331	Metazoa_SRP links to Rfam database...	0.62	0.61	0.63	53	37591	33	6	25	2	34
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	34	5424	2	0	2	0	2
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41236	46	8	36	2	34
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.93	0.92	0.94	33	5321	3	1	1	1	3
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	33	6751	2	1	1	0	2

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

2. Individual counts for TurboFold(seed) [ download as .csv ]

Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

2. Individual counts for Sfold [ download as .csv ]