CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	TurboFold(seed)		Vsfold4
MCC	0.785	>	0.215
Average MCC ± 95% Confidence Intervals	0.782 ± 0.060	>	0.302 ± 0.087
Sensitivity	0.758	>	0.197
Positive Predictive Value	0.814	>	0.239
Total TP	1475	>	384
Total TN	767553	<	767758
Total FP	530	<	1346
Total FP CONTRA	62	<	187
Total FP INCONS	276	<	1037
Total FP COMP	192	>	122
Total FN	472	<	1563
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of TurboFold(seed) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and Vsfold4).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and Vsfold4).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and Vsfold4).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP	1475
Total TN	767553
Total FP	530
Total FP CONTRA	62
Total FP INCONS	276
Total FP COMP	192
Total FN	472

Total Scores
MCC	0.785
Average MCC ± 95% Confidence Intervals	0.782 ± 0.060
Sensitivity	0.758
Positive Predictive Value	0.814
Nr of predictions	50

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
CRW_01535	5S_rRNA links to Rfam database...	0.94	0.89	1.00	33	7107	3	0	0	3	4
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	2	0	0	2	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00587	Y_RNA links to Rfam database...	1.00	1.00	1.00	15	4836	11	0	0	11	0
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00654	Vimentin3 links to Rfam database...	0.44	0.33	0.60	6	2405	5	1	3	1	12
RFA_00658	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	1118	5	0	3	2	7
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00703	Hammerhead_1 links to Rfam database...	0.67	0.64	0.69	9	4265	18	1	3	14	5
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	3	0	3	0	10
RFA_00749	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00764	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	5	0	2	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	2	1	0	1	8
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	1	0	1	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.38	0.38	0.40	6	2130	9	1	8	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.88	0.88	0.88	30	5426	4	1	3	0	4
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.61	0.66	0.58	19	5962	18	3	11	4	10
SRP_00137	Bacteria_small_SRP links to Rfam database...	0.75	0.84	0.68	21	4155	10	4	6	0	4
SRP_00146	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5216	3	1	2	0	2
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.90	0.92	0.89	33	6866	4	1	3	0	3
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.91	0.91	0.91	31	5426	3	1	2	0	3
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.95	0.93	0.97	28	3712	1	0	1	0	2
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	34	5424	2	0	2	0	2
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5319	3	1	2	0	2
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	33	6750	3	1	2	0	2

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	384
Total TN	767758
Total FP	1346
Total FP CONTRA	187
Total FP INCONS	1037
Total FP COMP	122
Total FN	1563

Total Scores
MCC	0.215
Average MCC ± 95% Confidence Intervals	0.302 ± 0.087
Sensitivity	0.197
Positive Predictive Value	0.239
Nr of predictions	50

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.10	0.09	0.11	6	27207	50	7	41	2	59
CRW_01535	5S_rRNA links to Rfam database...	0.26	0.24	0.29	9	7109	23	1	21	1	28
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
RFA_00390	Hammerhead_3 links to Rfam database...	0.93	0.87	1.00	13	1418	2	0	0	2	2
RFA_00416	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	3	0	0	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00587	Y_RNA links to Rfam database...	1.00	1.00	1.00	15	4836	11	0	0	11	0
RFA_00626	rne5 links to Rfam database...	0.20	0.18	0.22	16	56543	61	11	46	4	71
RFA_00627	rne5 links to Rfam database...	0.23	0.22	0.24	19	56874	63	13	47	3	68
RFA_00628	rne5 links to Rfam database...	0.24	0.22	0.26	19	57218	64	8	46	10	67
RFA_00630	rne5 links to Rfam database...	0.30	0.29	0.32	25	56875	58	3	50	5	62
RFA_00636	HDV_ribozyme links to Rfam database...	0.58	0.57	0.59	16	3978	11	1	10	0	12
RFA_00654	Vimentin3 links to Rfam database...	0.54	0.44	0.67	8	2403	5	1	3	1	10
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	5	0	3	2	10
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00703	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	4270	22	2	6	14	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00749	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00764	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00765	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00767	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1878	13	1	12	0	18
RFA_00768	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1875	16	1	15	0	18
RFA_00769	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	4	5	0	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	2003	15	2	11	2	18
RFA_00773	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1936	19	1	16	2	18
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	2	1	0	8
RFA_00808	RydC links to Rfam database...	0.62	0.56	0.69	9	2003	4	3	1	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10
RFA_00814	R2_retro_el links to Rfam database...	0.41	0.39	0.43	16	25163	33	3	18	12	25
RFA_00816	R2_retro_el links to Rfam database...	0.12	0.12	0.13	5	23181	42	9	25	8	36
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.11	5	21898	42	16	26	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20265	46	10	26	10	41
RFA_00819	R2_retro_el links to Rfam database...	0.20	0.20	0.21	8	27928	45	6	24	15	33
SRP_00084	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5437	23	1	22	0	34
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.16	0.17	0.16	5	5964	29	4	22	3	24
SRP_00137	Bacteria_small_SRP links to Rfam database...	0.39	0.40	0.38	10	4160	16	4	12	0	15
SRP_00146	Bacteria_small_SRP links to Rfam database...	0.36	0.33	0.40	12	5223	18	2	16	0	24
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6874	29	2	27	0	36
SRP_00231	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5435	25	4	21	0	34
SRP_00241	Plant_SRP links to Rfam database...	0.07	0.07	0.08	6	45978	74	13	59	2	76
SRP_00257	Metazoa_SRP links to Rfam database...	0.10	0.08	0.13	9	50971	60	1	59	0	99
SRP_00285	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	3719	22	2	20	0	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.13	0.11	0.14	10	36245	60	12	48	0	78
SRP_00328	Metazoa_SRP links to Rfam database...	0.18	0.16	0.20	14	39550	57	11	46	0	71
SRP_00329	Metazoa_SRP links to Rfam database...	0.17	0.15	0.20	13	39839	51	5	46	0	72
SRP_00331	Metazoa_SRP links to Rfam database...	0.14	0.13	0.16	11	37608	56	5	51	0	76
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.24	0.22	0.28	8	5431	21	2	19	0	28
SRP_00340	Metazoa_SRP links to Rfam database...	0.18	0.17	0.19	14	41256	58	11	47	0	68
SRP_00357	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5330	26	1	25	0	36
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6761	25	1	24	0	35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

2. Individual counts for TurboFold(seed) [ download as .csv ]

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]