CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Afold		NanoFolder
MCC	0.550	>	0.320
Average MCC ± 95% Confidence Intervals	0.568 ± 0.085	>	0.382 ± 0.079
Sensitivity	0.536	>	0.361
Positive Predictive Value	0.570	>	0.293
Total TP	831	>	559
Total TN	215337	>	214887
Total FP	731	<	1427
Total FP CONTRA	78	<	223
Total FP INCONS	548	<	1125
Total FP COMP	105	>	79
Total FN	718	<	990
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Afold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and NanoFolder).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	831
Total TN	215337
Total FP	731
Total FP CONTRA	78
Total FP INCONS	548
Total FP COMP	105
Total FN	718

Total Scores
MCC	0.550
Average MCC ± 95% Confidence Intervals	0.568 ± 0.085
Sensitivity	0.536
Positive Predictive Value	0.570
Nr of predictions	72

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_01539	5S_rRNA links to Rfam database...	0.81	0.76	0.88	28	7108	10	0	4	6	9
CRW_01563	5S_rRNA links to Rfam database...	0.57	0.51	0.63	19	6873	12	2	9	1	18
CRW_01583	5S_rRNA links to Rfam database...	0.79	0.76	0.82	28	7106	10	0	6	4	9
CRW_01590	5S_rRNA links to Rfam database...	0.21	0.22	0.21	8	7102	30	6	24	0	29
CRW_01603	5S_rRNA links to Rfam database...	0.82	0.78	0.85	29	7106	8	0	5	3	8
PDB_00011	-	0.91	0.83	1.00	10	266	0	0	0	0	2
PDB_00017	-	0.77	0.60	1.00	9	694	0	0	0	0	6
PDB_00036	-	-0.01	0.00	0.00	0	3461	27	1	24	2	27
PDB_00113	-	0.94	0.89	1.00	8	223	0	0	0	0	1
PDB_00119	-	0.95	0.90	1.00	9	244	0	0	0	0	1
PDB_00136	-	0.76	0.73	0.79	19	2391	7	0	5	2	7
PDB_00160	-	0.94	0.89	1.00	8	268	0	0	0	0	1
PDB_00178	-	0.90	0.82	1.00	9	519	1	0	0	1	2
PDB_00221	-	0.88	0.78	1.00	7	246	0	0	0	0	2
PDB_00312	-	1.00	1.00	1.00	9	426	0	0	0	0	0
PDB_00341	-	-0.02	0.00	0.00	0	691	12	0	12	0	16
PDB_00349	-	0.64	0.64	0.64	9	932	5	0	5	0	5
PDB_00417	-	0.10	0.11	0.11	6	14141	49	6	43	0	50
PDB_00527	-	-0.01	0.00	0.00	0	297	6	0	3	3	5
PDB_00565	-	0.77	0.70	0.85	35	8087	7	0	6	1	15
PDB_00570	-	-0.01	0.00	0.00	0	2257	21	2	19	0	22
PDB_00571	tRNA links to Rfam database...	-0.01	0.00	0.00	0	3302	20	5	14	1	25
PDB_00573	-	0.40	0.41	0.39	14	6634	24	4	18	2	20
PDB_00584	-	0.47	0.41	0.54	7	1472	6	0	6	0	10
PDB_00725	-	0.74	0.67	0.83	10	583	2	0	2	0	5
PDB_00734	-	0.83	0.70	1.00	7	224	0	0	0	0	3
PDB_00823	-	-0.03	0.00	0.00	0	185	5	0	5	0	9
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00890	-	-0.02	0.00	0.00	0	689	14	2	12	0	14
PDB_01009	tRNA links to Rfam database...	0.52	0.57	0.48	12	2460	13	5	8	0	9
PDB_01051	Telomerase-cil links to Rfam database...	0.75	0.69	0.82	9	892	6	0	2	4	4
PDB_01074	-	-0.01	0.00	0.00	0	2746	29	3	26	0	25
PDB_01130	-	-0.01	0.00	0.00	0	1746	24	6	18	0	20
PDB_01199	-	0.18	0.17	0.22	4	2127	14	0	14	0	20
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00434	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00446	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	3	0	0	3	1
RFA_00604	Telomerase-cil links to Rfam database...	0.72	0.74	0.70	26	13493	24	2	9	13	9
RFA_00664	Hammerhead_1 links to Rfam database...	0.07	0.07	0.09	1	979	11	0	10	1	13
RFA_00674	Hammerhead_1 links to Rfam database...	0.69	0.71	0.67	10	1113	6	0	5	1	4
RFA_00675	Hammerhead_1 links to Rfam database...	0.29	0.29	0.31	4	977	9	1	8	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.42	0.43	0.43	6	976	9	0	8	1	8
RFA_00684	Hammerhead_1 links to Rfam database...	0.66	0.64	0.69	9	977	5	0	4	1	5
RFA_00703	Hammerhead_1 links to Rfam database...	0.67	0.64	0.69	9	4265	18	1	3	14	5
RFA_00716	Hammerhead_1 links to Rfam database...	0.06	0.07	0.08	1	933	12	0	12	0	13
RFA_00717	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	889	5	0	5	0	5
RFA_00730	s2m links to Rfam database...	0.69	0.67	0.73	8	892	4	1	2	1	4
RFA_00763	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
SPR_00030	-	0.47	0.43	0.53	9	2468	8	0	8	0	12
SPR_00331	tRNA links to Rfam database...	0.32	0.35	0.30	7	2752	16	5	11	0	13
SPR_00333	tRNA links to Rfam database...	-0.01	0.00	0.00	0	2753	22	6	16	0	21
SPR_00509	tRNA links to Rfam database...	0.97	0.95	1.00	19	2907	3	0	0	3	1
SPR_00512	tRNA links to Rfam database...	0.97	0.95	1.00	19	2907	3	0	0	3	1
SPR_00557	tRNA links to Rfam database...	0.40	0.43	0.39	9	2827	15	1	13	1	12
SRP_00005	-	0.28	0.29	0.27	7	3979	21	4	15	2	17
SRP_00038	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5019	31	2	29	0	33
SRP_00193	-	0.67	0.67	0.69	24	6868	12	1	10	1	12
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.44	0.44	0.43	16	6866	21	2	19	0	20
SRP_00216	Bacteria_small_SRP links to Rfam database...	0.93	0.93	0.93	25	3376	3	1	1	1	2
SRP_00233	Bacteria_small_SRP links to Rfam database...	0.91	0.88	0.94	29	5120	2	0	2	0	4
SRP_00243	Bacteria_small_SRP links to Rfam database...	0.90	0.87	0.93	27	5122	3	0	2	1	4
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.86	0.88	0.85	35	6745	8	1	5	2	5
SRP_00303	Bacteria_small_SRP links to Rfam database...	0.60	0.63	0.59	20	6636	14	1	13	0	12
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.92	0.92	0.92	33	5424	4	0	3	1	3
SRP_00342	Bacteria_small_SRP links to Rfam database...	0.57	0.60	0.56	15	3978	17	1	11	5	10
SRP_00383	Bacteria_small_SRP links to Rfam database...	0.12	0.13	0.13	3	3216	21	3	18	0	21

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	559
Total TN	214887
Total FP	1427
Total FP CONTRA	223
Total FP INCONS	1125
Total FP COMP	79
Total FN	990

Total Scores
MCC	0.320
Average MCC ± 95% Confidence Intervals	0.382 ± 0.079
Sensitivity	0.361
Positive Predictive Value	0.293
Nr of predictions	72

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_01539	5S_rRNA links to Rfam database...	0.10	0.11	0.10	4	7099	40	1	36	3	33
CRW_01563	5S_rRNA links to Rfam database...	0.11	0.14	0.11	5	6856	43	5	37	1	32
CRW_01583	5S_rRNA links to Rfam database...	0.36	0.41	0.33	15	7095	31	8	22	1	22
CRW_01590	5S_rRNA links to Rfam database...	-0.01	0.00	0.00	0	7093	50	7	40	3	37
CRW_01603	5S_rRNA links to Rfam database...	0.41	0.46	0.38	17	7095	29	6	22	1	20
PDB_00011	-	0.96	0.92	1.00	11	265	0	0	0	0	1
PDB_00017	-	0.66	0.67	0.67	10	688	5	1	4	0	5
PDB_00036	-	-0.01	0.00	0.00	0	3457	29	1	28	0	27
PDB_00113	-	0.94	0.89	1.00	8	223	0	0	0	0	1
PDB_00119	-	0.95	0.90	1.00	9	244	0	0	0	0	1
PDB_00136	-	0.70	0.73	0.68	19	2387	9	1	8	0	7
PDB_00160	-	0.89	0.89	0.89	8	267	2	0	1	1	1
PDB_00178	-	-0.02	0.00	0.00	0	517	11	1	10	0	11
PDB_00221	-	0.94	0.89	1.00	8	245	0	0	0	0	1
PDB_00312	-	1.00	1.00	1.00	9	426	1	0	0	1	0
PDB_00341	-	0.47	0.44	0.54	7	690	6	0	6	0	9
PDB_00349	-	0.10	0.14	0.10	2	926	18	0	18	0	12
PDB_00417	-	0.00	0.00	0.00	0	14138	58	2	56	0	56
PDB_00527	-	-0.02	0.00	0.00	0	292	8	2	6	0	5
PDB_00565	-	0.24	0.24	0.24	12	8079	37	1	36	0	38
PDB_00570	-	-0.01	0.00	0.00	0	2257	21	0	21	0	22
PDB_00571	tRNA links to Rfam database...	-0.01	0.00	0.00	0	3286	36	6	29	1	25
PDB_00573	-	-0.01	0.00	0.00	0	6622	48	5	43	0	34
PDB_00584	-	0.47	0.53	0.43	9	1464	12	1	11	0	8
PDB_00725	-	0.82	0.80	0.86	12	581	2	0	2	0	3
PDB_00734	-	0.83	0.70	1.00	7	224	0	0	0	0	3
PDB_00823	-	-0.04	0.00	0.00	0	183	7	0	7	0	9
PDB_00828	Purine links to Rfam database...	0.30	0.33	0.28	9	2453	23	0	23	0	18
PDB_00890	-	-0.02	0.00	0.00	0	690	13	2	11	0	14
PDB_01009	tRNA links to Rfam database...	0.27	0.33	0.23	7	2455	25	3	20	2	14
PDB_01051	Telomerase-cil links to Rfam database...	-0.02	0.00	0.00	0	885	18	1	17	0	13
PDB_01074	-	-0.01	0.00	0.00	0	2747	28	3	25	0	25
PDB_01130	-	-0.01	0.00	0.00	0	1742	28	5	23	0	20
PDB_01199	-	-0.01	0.00	0.00	0	2116	29	2	27	0	24
RFA_00416	Hammerhead_3 links to Rfam database...	0.94	1.00	0.88	15	1468	6	2	0	4	0
RFA_00434	Hammerhead_3 links to Rfam database...	0.84	1.00	0.71	15	1410	8	6	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	0.86	1.00	0.75	15	1411	7	5	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	0.94	1.00	0.88	15	1414	4	2	0	2	0
RFA_00446	Hammerhead_3 links to Rfam database...	0.85	0.93	0.78	14	1467	7	3	1	3	1
RFA_00604	Telomerase-cil links to Rfam database...	0.42	0.54	0.33	19	13472	53	14	25	14	16
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	978	13	0	12	1	14
RFA_00674	Hammerhead_1 links to Rfam database...	0.12	0.14	0.13	2	1112	15	0	14	1	12
RFA_00675	Hammerhead_1 links to Rfam database...	0.28	0.29	0.29	4	976	10	1	9	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.62	0.64	0.60	9	975	10	0	6	4	5
RFA_00684	Hammerhead_1 links to Rfam database...	0.74	0.71	0.77	10	977	5	2	1	2	4
RFA_00703	Hammerhead_1 links to Rfam database...	0.26	0.36	0.19	5	4252	32	5	16	11	9
RFA_00716	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	929	17	0	17	0	14
RFA_00717	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	889	5	2	3	0	5
RFA_00730	s2m links to Rfam database...	0.38	0.42	0.36	5	889	10	3	6	1	7
RFA_00763	s2m links to Rfam database...	0.38	0.42	0.36	5	889	10	3	6	1	7
RFA_00765	s2m links to Rfam database...	0.39	0.42	0.38	5	890	9	2	6	1	7
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1996	24	0	20	4	18
RFA_00773	Corona_pk3 links to Rfam database...	0.93	1.00	0.86	18	1932	9	3	0	6	0
RFA_00808	RydC links to Rfam database...	0.83	1.00	0.70	16	1993	7	7	0	0	0
SPR_00030	-	0.47	0.52	0.42	11	2459	16	2	13	1	10
SPR_00331	tRNA links to Rfam database...	0.48	0.60	0.39	12	2744	19	6	13	0	8
SPR_00333	tRNA links to Rfam database...	0.25	0.33	0.21	7	2741	27	10	17	0	14
SPR_00509	tRNA links to Rfam database...	0.23	0.30	0.19	6	2895	25	8	17	0	14
SPR_00512	tRNA links to Rfam database...	0.61	0.75	0.50	15	2896	15	6	9	0	5
SPR_00557	tRNA links to Rfam database...	0.42	0.52	0.34	11	2818	22	8	13	1	10
SRP_00005	-	-0.01	0.00	0.00	0	3966	39	6	33	0	24
SRP_00038	Bacteria_small_SRP links to Rfam database...	0.23	0.27	0.20	9	5005	36	1	35	0	24
SRP_00193	-	0.16	0.19	0.15	7	6855	43	4	37	2	29
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.41	0.47	0.35	17	6855	31	4	27	0	19
SRP_00216	Bacteria_small_SRP links to Rfam database...	0.44	0.48	0.41	13	3371	19	4	15	0	14
SRP_00233	Bacteria_small_SRP links to Rfam database...	0.25	0.30	0.22	10	5106	35	4	31	0	23
SRP_00243	Bacteria_small_SRP links to Rfam database...	0.47	0.55	0.40	17	5109	25	7	18	0	14
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.36	0.40	0.33	16	6737	34	6	27	1	24
SRP_00303	Bacteria_small_SRP links to Rfam database...	0.36	0.41	0.33	13	6630	27	3	24	0	19
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.52	0.56	0.49	20	5419	22	4	17	1	16
SRP_00342	Bacteria_small_SRP links to Rfam database...	0.20	0.24	0.17	6	3970	29	7	22	0	19
SRP_00383	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	3205	35	9	26	0	24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]