CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Alterna		NanoFolder
MCC	0.573	>	0.390
Average MCC ± 95% Confidence Intervals	0.594 ± 0.069	>	0.430 ± 0.068
Sensitivity	0.561	>	0.447
Positive Predictive Value	0.593	>	0.350
Total TP	906	>	722
Total TN	183099	>	182563
Total FP	716	<	1432
Total FP CONTRA	86	<	312
Total FP INCONS	537	<	1031
Total FP COMP	93	>	89
Total FN	708	<	892
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Alterna and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Alterna and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and NanoFolder).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP	906
Total TN	183099
Total FP	716
Total FP CONTRA	86
Total FP INCONS	537
Total FP COMP	93
Total FN	708

Total Scores
MCC	0.573
Average MCC ± 95% Confidence Intervals	0.594 ± 0.069
Sensitivity	0.561
Positive Predictive Value	0.593
Nr of predictions	87

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00011	-	0.91	0.83	1.00	10	266	0	0	0	0	2
PDB_00017	-	0.66	0.60	0.75	9	691	3	0	3	0	6
PDB_00036	-	-0.01	0.00	0.00	0	3459	27	1	26	0	27
PDB_00070	tRNA links to Rfam database...	0.62	0.63	0.63	15	2826	9	1	8	0	9
PDB_00113	-	0.94	0.89	1.00	8	223	0	0	0	0	1
PDB_00119	-	0.95	0.90	1.00	9	244	0	0	0	0	1
PDB_00136	-	0.90	0.85	0.96	22	2392	3	0	1	2	4
PDB_00137	-	0.87	0.77	1.00	10	396	0	0	0	0	3
PDB_00160	-	0.94	0.89	1.00	8	268	0	0	0	0	1
PDB_00178	-	0.68	0.55	0.86	6	521	2	0	1	1	5
PDB_00221	-	0.88	0.78	1.00	7	246	0	0	0	0	2
PDB_00312	-	1.00	1.00	1.00	9	426	0	0	0	0	0
PDB_00326	-	0.53	0.46	0.62	13	3720	9	0	8	1	15
PDB_00341	-	0.52	0.44	0.64	7	692	4	0	4	0	9
PDB_00349	-	0.92	0.86	1.00	12	934	0	0	0	0	2
PDB_00430	tRNA links to Rfam database...	0.68	0.68	0.68	17	3215	8	3	5	0	8
PDB_00527	-	-0.01	0.00	0.00	0	296	4	1	3	0	5
PDB_00570	-	-0.01	0.00	0.00	0	2268	10	1	9	0	22
PDB_00571	tRNA links to Rfam database...	0.41	0.40	0.43	10	3298	13	3	10	0	15
PDB_00584	-	0.25	0.24	0.29	4	1471	11	0	10	1	13
PDB_00698	-	0.94	0.89	1.00	17	844	0	0	0	0	2
PDB_00725	-	0.73	0.53	1.00	8	587	0	0	0	0	7
PDB_00734	-	0.83	0.70	1.00	7	224	0	0	0	0	3
PDB_00823	-	-0.03	0.00	0.00	0	185	5	0	5	0	9
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00851	-	0.10	0.10	0.13	4	4721	28	0	28	0	37
PDB_00890	-	-0.02	0.00	0.00	0	690	13	2	11	0	14
PDB_00923	-	1.00	1.00	1.00	6	184	0	0	0	0	0
PDB_01009	tRNA links to Rfam database...	0.86	0.86	0.86	18	2464	6	0	3	3	3
PDB_01051	Telomerase-cil links to Rfam database...	0.55	0.54	0.58	7	891	6	1	4	1	6
PDB_01074	-	-0.01	0.00	0.00	0	2746	29	3	26	0	25
PDB_01130	-	-0.01	0.00	0.00	0	1749	21	4	17	0	20
PDB_01199	-	0.91	0.83	1.00	20	2125	0	0	0	0	4
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00434	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00446	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	2	0	0	2	1
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	10	0	10	0	14
RFA_00674	Hammerhead_1 links to Rfam database...	0.74	0.71	0.77	10	1115	4	0	3	1	4
RFA_00675	Hammerhead_1 links to Rfam database...	0.29	0.29	0.31	4	977	9	1	8	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.59	0.57	0.62	8	977	7	0	5	2	6
RFA_00684	Hammerhead_1 links to Rfam database...	0.77	0.71	0.83	10	978	4	0	2	2	4
RFA_00703	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	4266	16	1	2	13	5
RFA_00716	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	936	10	0	10	0	14
RFA_00717	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	891	3	0	3	0	5
RFA_00730	s2m links to Rfam database...	0.69	0.67	0.73	8	892	5	1	2	2	4
RFA_00763	s2m links to Rfam database...	0.43	0.42	0.45	5	892	7	1	5	1	7
RFA_00765	s2m links to Rfam database...	0.81	0.67	1.00	8	895	2	0	0	2	4
RFA_00770	Corona_pk3 links to Rfam database...	0.45	0.39	0.54	7	2003	9	0	6	3	11
RFA_00773	Corona_pk3 links to Rfam database...	0.45	0.39	0.54	7	1940	9	0	6	3	11
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	1999	19	3	14	2	16
SPR_00030	-	0.58	0.57	0.60	12	2465	9	2	6	1	9
SPR_00066	tRNA links to Rfam database...	1.00	1.00	1.00	21	2829	0	0	0	0	0
SPR_00228	tRNA links to Rfam database...	0.61	0.60	0.63	12	3809	9	1	6	2	8
SPR_00314	tRNA links to Rfam database...	0.74	0.81	0.68	17	2901	11	0	8	3	4
SPR_00331	tRNA links to Rfam database...	0.71	0.75	0.68	15	2753	7	2	5	0	5
SPR_00333	tRNA links to Rfam database...	0.55	0.62	0.50	13	2749	13	4	9	0	8
SPR_00353	tRNA links to Rfam database...	1.00	1.00	1.00	21	2829	0	0	0	0	0
SPR_00398	-	-0.01	0.00	0.00	0	2192	21	3	16	2	13
SPR_00452	tRNA links to Rfam database...	0.73	0.76	0.70	16	2827	7	3	4	0	5
SPR_00456	tRNA links to Rfam database...	0.55	0.57	0.55	12	2828	13	1	9	3	9
SPR_00462	tRNA links to Rfam database...	0.72	0.74	0.70	14	2395	7	3	3	1	5
SPR_00476	tRNA links to Rfam database...	0.50	0.52	0.48	11	2752	12	3	9	0	10
SPR_00496	tRNA links to Rfam database...	0.48	0.52	0.44	11	2750	14	3	11	0	10
SPR_00497	tRNA links to Rfam database...	0.50	0.52	0.48	11	2752	12	3	9	0	10
SPR_00502	tRNA links to Rfam database...	0.56	0.57	0.55	12	2904	10	2	8	0	9
SPR_00509	tRNA links to Rfam database...	1.00	1.00	1.00	20	2906	2	0	0	2	0
SPR_00512	tRNA links to Rfam database...	1.00	1.00	1.00	20	2906	2	0	0	2	0
SPR_00542	tRNA links to Rfam database...	0.30	0.33	0.28	7	3545	21	2	16	3	14
SPR_00557	tRNA links to Rfam database...	0.50	0.52	0.48	11	2827	12	2	10	0	10
SPR_00832	-	0.64	0.67	0.63	10	1637	8	2	4	2	5
SPR_00868	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	3	0	0	3	0
SPR_00932	tRNA links to Rfam database...	0.34	0.38	0.32	8	2825	18	4	13	1	13
SPR_00957	tRNA links to Rfam database...	0.83	0.81	0.85	17	2983	4	0	3	1	4
SPR_01040	tRNA links to Rfam database...	0.60	0.57	0.63	12	2756	8	0	7	1	9
SPR_01143	tRNA links to Rfam database...	0.48	0.33	0.70	7	2546	3	0	3	0	14
SRP_00005	-	0.15	0.17	0.15	4	3978	24	6	17	1	20
SRP_00046	Bacteria_small_SRP links to Rfam database...	0.56	0.56	0.56	18	4721	15	1	13	1	14
SRP_00138	-	0.51	0.48	0.54	13	3981	13	2	9	2	14
SRP_00170	Bacteria_small_SRP links to Rfam database...	0.34	0.36	0.33	9	4068	19	0	18	1	16
SRP_00194	Bacteria_small_SRP links to Rfam database...	0.73	0.76	0.70	16	3217	10	0	7	3	5
SRP_00216	Bacteria_small_SRP links to Rfam database...	0.85	0.85	0.85	23	3376	5	1	3	1	4
SRP_00266	Bacteria_small_SRP links to Rfam database...	0.32	0.34	0.30	10	4623	23	4	19	0	19
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.77	0.73	0.81	22	3714	6	0	5	1	8
SRP_00342	Bacteria_small_SRP links to Rfam database...	0.57	0.60	0.56	15	3978	17	1	11	5	10
SRP_00383	Bacteria_small_SRP links to Rfam database...	0.12	0.13	0.13	3	3216	21	4	17	0	21

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	722
Total TN	182563
Total FP	1432
Total FP CONTRA	312
Total FP INCONS	1031
Total FP COMP	89
Total FN	892

Total Scores
MCC	0.390
Average MCC ± 95% Confidence Intervals	0.430 ± 0.068
Sensitivity	0.447
Positive Predictive Value	0.350
Nr of predictions	87

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00011	-	0.96	0.92	1.00	11	265	0	0	0	0	1
PDB_00017	-	0.66	0.67	0.67	10	688	5	1	4	0	5
PDB_00036	-	-0.01	0.00	0.00	0	3457	29	1	28	0	27
PDB_00070	tRNA links to Rfam database...	0.25	0.29	0.23	7	2819	24	4	20	0	17
PDB_00113	-	0.94	0.89	1.00	8	223	0	0	0	0	1
PDB_00119	-	0.95	0.90	1.00	9	244	0	0	0	0	1
PDB_00136	-	0.70	0.73	0.68	19	2387	9	1	8	0	7
PDB_00137	-	0.87	0.77	1.00	10	396	0	0	0	0	3
PDB_00160	-	0.89	0.89	0.89	8	267	2	0	1	1	1
PDB_00178	-	-0.02	0.00	0.00	0	517	11	1	10	0	11
PDB_00221	-	0.94	0.89	1.00	8	245	0	0	0	0	1
PDB_00312	-	1.00	1.00	1.00	9	426	1	0	0	1	0
PDB_00326	-	0.58	0.64	0.53	18	3707	16	4	12	0	10
PDB_00341	-	0.47	0.44	0.54	7	690	6	0	6	0	9
PDB_00349	-	0.10	0.14	0.10	2	926	18	0	18	0	12
PDB_00430	tRNA links to Rfam database...	0.38	0.44	0.34	11	3208	21	6	15	0	14
PDB_00527	-	-0.02	0.00	0.00	0	292	8	2	6	0	5
PDB_00570	-	-0.01	0.00	0.00	0	2257	21	0	21	0	22
PDB_00571	tRNA links to Rfam database...	-0.01	0.00	0.00	0	3286	36	6	29	1	25
PDB_00584	-	0.47	0.53	0.43	9	1464	12	1	11	0	8
PDB_00698	-	0.97	0.95	1.00	18	843	0	0	0	0	1
PDB_00725	-	0.82	0.80	0.86	12	581	2	0	2	0	3
PDB_00734	-	0.83	0.70	1.00	7	224	0	0	0	0	3
PDB_00823	-	-0.04	0.00	0.00	0	183	7	0	7	0	9
PDB_00828	Purine links to Rfam database...	0.30	0.33	0.28	9	2453	23	0	23	0	18
PDB_00851	-	0.16	0.17	0.17	7	4711	35	3	32	0	34
PDB_00890	-	-0.02	0.00	0.00	0	690	13	2	11	0	14
PDB_00923	-	1.00	1.00	1.00	6	184	2	0	0	2	0
PDB_01009	tRNA links to Rfam database...	0.27	0.33	0.23	7	2455	25	3	20	2	14
PDB_01051	Telomerase-cil links to Rfam database...	-0.02	0.00	0.00	0	885	18	1	17	0	13
PDB_01074	-	-0.01	0.00	0.00	0	2747	28	3	25	0	25
PDB_01130	-	-0.01	0.00	0.00	0	1742	28	5	23	0	20
PDB_01199	-	-0.01	0.00	0.00	0	2116	29	2	27	0	24
RFA_00416	Hammerhead_3 links to Rfam database...	0.94	1.00	0.88	15	1468	6	2	0	4	0
RFA_00434	Hammerhead_3 links to Rfam database...	0.84	1.00	0.71	15	1410	8	6	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	0.86	1.00	0.75	15	1411	7	5	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	0.94	1.00	0.88	15	1414	4	2	0	2	0
RFA_00446	Hammerhead_3 links to Rfam database...	0.85	0.93	0.78	14	1467	7	3	1	3	1
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	978	13	0	12	1	14
RFA_00674	Hammerhead_1 links to Rfam database...	0.12	0.14	0.13	2	1112	15	0	14	1	12
RFA_00675	Hammerhead_1 links to Rfam database...	0.28	0.29	0.29	4	976	10	1	9	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.62	0.64	0.60	9	975	10	0	6	4	5
RFA_00684	Hammerhead_1 links to Rfam database...	0.74	0.71	0.77	10	977	5	2	1	2	4
RFA_00703	Hammerhead_1 links to Rfam database...	0.26	0.36	0.19	5	4252	32	5	16	11	9
RFA_00716	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	929	17	0	17	0	14
RFA_00717	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	889	5	2	3	0	5
RFA_00730	s2m links to Rfam database...	0.38	0.42	0.36	5	889	10	3	6	1	7
RFA_00763	s2m links to Rfam database...	0.38	0.42	0.36	5	889	10	3	6	1	7
RFA_00765	s2m links to Rfam database...	0.39	0.42	0.38	5	890	9	2	6	1	7
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1996	24	0	20	4	18
RFA_00773	Corona_pk3 links to Rfam database...	0.93	1.00	0.86	18	1932	9	3	0	6	0
RFA_00808	RydC links to Rfam database...	0.83	1.00	0.70	16	1993	7	7	0	0	0
SPR_00030	-	0.47	0.52	0.42	11	2459	16	2	13	1	10
SPR_00066	tRNA links to Rfam database...	0.47	0.57	0.39	12	2819	20	4	15	1	9
SPR_00228	tRNA links to Rfam database...	0.44	0.60	0.32	12	3791	26	15	10	1	8
SPR_00314	tRNA links to Rfam database...	0.47	0.57	0.39	12	2895	21	9	10	2	9
SPR_00331	tRNA links to Rfam database...	0.48	0.60	0.39	12	2744	19	6	13	0	8
SPR_00333	tRNA links to Rfam database...	0.25	0.33	0.21	7	2741	27	10	17	0	14
SPR_00353	tRNA links to Rfam database...	0.64	0.81	0.52	17	2817	16	8	8	0	4
SPR_00398	-	-0.01	0.00	0.00	0	2185	28	10	16	2	13
SPR_00452	tRNA links to Rfam database...	0.27	0.33	0.23	7	2820	24	7	16	1	14
SPR_00456	tRNA links to Rfam database...	0.49	0.57	0.43	12	2822	19	5	11	3	9
SPR_00462	tRNA links to Rfam database...	0.65	0.74	0.58	14	2391	11	4	6	1	5
SPR_00476	tRNA links to Rfam database...	0.47	0.52	0.42	11	2749	17	4	11	2	10
SPR_00496	tRNA links to Rfam database...	0.47	0.57	0.40	12	2745	22	7	11	4	9
SPR_00497	tRNA links to Rfam database...	0.27	0.33	0.23	7	2745	23	5	18	0	14
SPR_00502	tRNA links to Rfam database...	0.27	0.33	0.23	7	2896	26	2	21	3	14
SPR_00509	tRNA links to Rfam database...	0.23	0.30	0.19	6	2895	25	8	17	0	14
SPR_00512	tRNA links to Rfam database...	0.61	0.75	0.50	15	2896	15	6	9	0	5
SPR_00542	tRNA links to Rfam database...	0.26	0.33	0.22	7	3538	28	4	21	3	14
SPR_00557	tRNA links to Rfam database...	0.42	0.52	0.34	11	2818	22	8	13	1	10
SPR_00832	-	0.53	0.67	0.43	10	1630	13	5	8	0	5
SPR_00868	tRNA links to Rfam database...	0.49	0.57	0.43	12	2898	19	5	11	3	9
SPR_00932	tRNA links to Rfam database...	0.43	0.52	0.35	11	2819	21	7	13	1	10
SPR_00957	tRNA links to Rfam database...	0.63	0.76	0.53	16	2973	15	7	7	1	5
SPR_01040	tRNA links to Rfam database...	0.15	0.19	0.13	4	2744	27	4	23	0	17
SPR_01143	tRNA links to Rfam database...	0.41	0.48	0.36	10	2528	18	8	10	0	11
SRP_00005	-	-0.01	0.00	0.00	0	3966	39	6	33	0	24
SRP_00046	Bacteria_small_SRP links to Rfam database...	0.33	0.38	0.29	12	4712	30	3	26	1	20
SRP_00138	-	0.44	0.52	0.39	14	3969	24	8	14	2	13
SRP_00170	Bacteria_small_SRP links to Rfam database...	0.29	0.36	0.25	9	4059	28	4	23	1	16
SRP_00194	Bacteria_small_SRP links to Rfam database...	0.27	0.33	0.23	7	3209	27	5	19	3	14
SRP_00216	Bacteria_small_SRP links to Rfam database...	0.44	0.48	0.41	13	3371	19	4	15	0	14
SRP_00266	Bacteria_small_SRP links to Rfam database...	0.55	0.66	0.46	19	4615	22	8	14	0	10
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.38	0.43	0.35	13	3704	24	6	18	0	17
SRP_00342	Bacteria_small_SRP links to Rfam database...	0.20	0.24	0.17	6	3970	29	7	22	0	19
SRP_00383	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	3205	35	9	26	0	24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

2. Individual counts for Alterna [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]