CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CMfinder(seed)		MCFold
MCC	0.555	>	0.396
Average MCC ± 95% Confidence Intervals	0.530 ± 0.069	>	0.429 ± 0.074
Sensitivity	0.421	<	0.436
Positive Predictive Value	0.736	>	0.367
Total TP	479	<	496
Total TN	167864	>	167165
Total FP	213	<	1040
Total FP CONTRA	5	<	134
Total FP INCONS	167	<	720
Total FP COMP	41	<	186
Total FN	658	>	641
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CMfinder(seed) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and MCFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and MCFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and MCFold).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	479
Total TN	167864
Total FP	213
Total FP CONTRA	5
Total FP INCONS	167
Total FP COMP	41
Total FN	658

Total Scores
MCC	0.555
Average MCC ± 95% Confidence Intervals	0.530 ± 0.069
Sensitivity	0.421
Positive Predictive Value	0.736
Nr of predictions	68

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	2	0	0	2	0
PDB_00553	mir-TAR links to Rfam database...	0.00	0.00	0.00	0	465	0	0	0	0	11
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00810	s2m links to Rfam database...	0.76	0.59	1.00	10	1071	0	0	0	0	7
PDB_01050	UnaL2 links to Rfam database...	0.68	0.46	1.00	6	624	1	0	0	1	7
PDB_01051	Telomerase-cil links to Rfam database...	0.83	0.69	1.00	9	894	4	0	0	4	4
PDB_01152	HIV_FS2 links to Rfam database...	0.92	0.86	1.00	12	549	0	0	0	0	2
RFA_00603	Telomerase-cil links to Rfam database...	0.70	0.60	0.81	21	13504	7	0	5	2	14
RFA_00604	Telomerase-cil links to Rfam database...	0.63	0.51	0.78	18	13507	8	0	5	3	17
RFA_00610	Telomerase-cil links to Rfam database...	0.39	0.30	0.52	11	17184	13	2	8	3	26
RFA_00611	Telomerase-cil links to Rfam database...	0.65	0.51	0.82	18	13019	5	0	4	1	17
RFA_00613	Telomerase-cil links to Rfam database...	0.70	0.57	0.87	20	12857	4	0	3	1	15
RFA_00615	Telomerase-cil links to Rfam database...	0.57	0.49	0.68	17	13341	10	0	8	2	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00642	Vimentin3 links to Rfam database...	0.44	0.28	0.71	5	2919	2	0	2	0	13
RFA_00643	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2203	8	0	8	0	18
RFA_00644	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2693	8	0	8	0	18
RFA_00645	Vimentin3 links to Rfam database...	0.29	0.17	0.50	3	2409	3	0	3	0	15
RFA_00649	Vimentin3 links to Rfam database...	0.35	0.22	0.57	4	2138	3	0	3	0	14
RFA_00651	Vimentin3 links to Rfam database...	0.35	0.22	0.57	4	2073	3	0	3	0	14
RFA_00653	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2137	8	0	8	0	18
RFA_00654	Vimentin3 links to Rfam database...	0.38	0.22	0.67	4	2409	2	0	2	0	14
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00659	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00667	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00668	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00672	Hammerhead_1 links to Rfam database...	0.41	0.31	0.57	4	896	3	0	3	0	9
RFA_00673	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00674	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00675	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00677	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00678	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00680	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00684	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	984	3	0	2	1	10
RFA_00685	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00704	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00705	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00706	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00707	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00709	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00710	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	3	0	3	0	11
RFA_00711	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00715	Hammerhead_1 links to Rfam database...	0.30	0.14	0.67	2	943	2	0	1	1	12
RFA_00716	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00717	Hammerhead_1 links to Rfam database...	0.30	0.21	0.43	3	896	4	0	4	0	11
RFA_00730	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00731	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00733	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00734	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00736	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00737	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00745	s2m links to Rfam database...	0.91	0.83	1.00	10	936	0	0	0	0	2
RFA_00749	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00758	s2m links to Rfam database...	0.86	0.75	1.00	9	894	0	0	0	0	3
RFA_00762	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00763	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00764	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00765	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00786	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP	496
Total TN	167165
Total FP	1040
Total FP CONTRA	134
Total FP INCONS	720
Total FP COMP	186
Total FN	641

Total Scores
MCC	0.396
Average MCC ± 95% Confidence Intervals	0.429 ± 0.074
Sensitivity	0.436
Positive Predictive Value	0.367
Nr of predictions	68

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.76	0.79	0.73	11	931	6	2	2	2	3
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	4	0	0	4	0
PDB_00553	mir-TAR links to Rfam database...	1.00	1.00	1.00	11	454	1	0	0	1	0
PDB_00716	HDV_ribozyme links to Rfam database...	0.22	0.26	0.19	6	2670	25	5	20	0	17
PDB_00810	s2m links to Rfam database...	0.74	0.76	0.72	13	1063	7	0	5	2	4
PDB_01050	UnaL2 links to Rfam database...	1.00	1.00	1.00	13	617	3	0	0	3	0
PDB_01051	Telomerase-cil links to Rfam database...	1.00	1.00	1.00	13	890	5	0	0	5	0
PDB_01152	HIV_FS2 links to Rfam database...	1.00	1.00	1.00	14	547	1	0	0	1	0
RFA_00603	Telomerase-cil links to Rfam database...	0.67	0.60	0.75	21	13502	11	4	3	4	14
RFA_00604	Telomerase-cil links to Rfam database...	0.97	0.97	0.97	34	13495	15	0	1	14	1
RFA_00610	Telomerase-cil links to Rfam database...	0.70	0.54	0.91	20	17183	8	0	2	6	17
RFA_00611	Telomerase-cil links to Rfam database...	0.51	0.49	0.53	17	13009	20	6	9	5	18
RFA_00613	Telomerase-cil links to Rfam database...	0.24	0.23	0.26	8	12849	26	2	21	3	27
RFA_00615	Telomerase-cil links to Rfam database...	0.16	0.14	0.19	5	13339	22	5	17	0	30
RFA_00636	HDV_ribozyme links to Rfam database...	0.36	0.39	0.34	11	3973	29	0	21	8	17
RFA_00642	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2894	32	7	25	0	18
RFA_00643	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2186	27	2	23	2	18
RFA_00644	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2670	33	7	24	2	18
RFA_00645	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2387	28	3	25	0	18
RFA_00649	Vimentin3 links to Rfam database...	0.28	0.33	0.24	6	2120	22	2	17	3	12
RFA_00651	Vimentin3 links to Rfam database...	0.25	0.28	0.24	5	2059	21	0	16	5	13
RFA_00653	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2115	30	4	26	0	18
RFA_00654	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2386	29	4	25	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.62	0.64	0.60	9	1113	10	0	6	4	5
RFA_00659	Hammerhead_1 links to Rfam database...	0.31	0.36	0.28	5	1110	16	1	12	3	9
RFA_00664	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	974	16	0	16	0	14
RFA_00667	Hammerhead_1 links to Rfam database...	0.35	0.43	0.30	6	970	15	1	13	1	8
RFA_00668	Hammerhead_1 links to Rfam database...	0.23	0.29	0.20	4	970	16	3	13	0	10
RFA_00672	Hammerhead_1 links to Rfam database...	0.69	0.77	0.63	10	887	9	0	6	3	3
RFA_00673	Hammerhead_1 links to Rfam database...	0.60	0.64	0.56	9	1112	12	0	7	5	5
RFA_00674	Hammerhead_1 links to Rfam database...	0.96	0.93	1.00	13	1115	7	0	0	7	1
RFA_00675	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	974	18	0	16	2	14
RFA_00677	Hammerhead_1 links to Rfam database...	0.46	0.50	0.44	7	974	12	0	9	3	7
RFA_00678	Hammerhead_1 links to Rfam database...	0.69	0.71	0.67	10	931	8	0	5	3	4
RFA_00680	Hammerhead_1 links to Rfam database...	0.62	0.64	0.60	9	1113	11	0	6	5	5
RFA_00684	Hammerhead_1 links to Rfam database...	0.57	0.57	0.57	8	976	10	0	6	4	6
RFA_00685	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	976	10	0	5	5	5
RFA_00704	Hammerhead_1 links to Rfam database...	0.37	0.43	0.33	6	972	13	1	11	1	8
RFA_00705	Hammerhead_1 links to Rfam database...	0.35	0.43	0.30	6	1015	14	4	10	0	8
RFA_00706	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	1016	19	5	14	0	14
RFA_00707	Hammerhead_1 links to Rfam database...	0.36	0.43	0.32	6	1016	13	5	8	0	8
RFA_00708	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	1021	10	0	5	5	5
RFA_00709	Hammerhead_1 links to Rfam database...	0.38	0.43	0.35	6	973	12	0	11	1	8
RFA_00710	Hammerhead_1 links to Rfam database...	0.41	0.43	0.40	6	975	13	0	9	4	8
RFA_00711	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	1017	18	5	13	0	14
RFA_00715	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	929	17	0	17	0	14
RFA_00716	Hammerhead_1 links to Rfam database...	0.05	0.07	0.06	1	928	17	0	17	0	13
RFA_00717	Hammerhead_1 links to Rfam database...	0.36	0.43	0.32	6	884	13	0	13	0	8
RFA_00730	s2m links to Rfam database...	0.33	0.42	0.28	5	885	14	5	8	1	7
RFA_00731	s2m links to Rfam database...	0.34	0.42	0.29	5	886	13	4	8	1	7
RFA_00733	s2m links to Rfam database...	0.72	0.75	0.69	9	890	10	0	4	6	3
RFA_00734	s2m links to Rfam database...	0.51	0.58	0.47	7	888	12	1	7	4	5
RFA_00736	s2m links to Rfam database...	0.34	0.42	0.29	5	886	13	4	8	1	7
RFA_00737	s2m links to Rfam database...	0.34	0.42	0.29	5	886	13	4	8	1	7
RFA_00745	s2m links to Rfam database...	0.72	0.75	0.69	9	933	11	0	4	7	3
RFA_00749	s2m links to Rfam database...	0.34	0.42	0.29	5	886	13	4	8	1	7
RFA_00758	s2m links to Rfam database...	0.59	0.67	0.53	8	888	10	2	5	3	4
RFA_00762	s2m links to Rfam database...	0.33	0.42	0.28	5	885	13	5	8	0	7
RFA_00763	s2m links to Rfam database...	0.72	0.75	0.69	9	890	10	0	4	6	3
RFA_00764	s2m links to Rfam database...	0.72	0.75	0.69	9	890	10	0	4	6	3
RFA_00765	s2m links to Rfam database...	0.72	0.75	0.69	9	890	10	0	4	6	3
RFA_00769	Corona_pk3 links to Rfam database...	0.45	0.50	0.41	9	1931	18	2	11	5	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1992	29	2	22	5	18
RFA_00773	Corona_pk3 links to Rfam database...	0.43	0.50	0.38	9	1929	16	4	11	1	9
RFA_00779	Corona_pk3 links to Rfam database...	0.45	0.56	0.37	10	1926	17	7	10	0	8
RFA_00786	Gammaretro_CES links to Rfam database...	0.13	0.16	0.12	5	5008	37	5	32	0	27
RFA_00808	RydC links to Rfam database...	0.39	0.44	0.35	7	1996	19	1	12	6	9
RFA_00809	RydC links to Rfam database...	0.30	0.38	0.25	6	2121	18	6	12	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

2. Individual counts for MCFold [ download as .csv ]