CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CMfinder(seed)		RNAwolf
MCC	0.571	>	0.369
Average MCC ± 95% Confidence Intervals	0.537 ± 0.067	>	0.371 ± 0.063
Sensitivity	0.439	>	0.369
Positive Predictive Value	0.747	>	0.377
Total TP	656	>	552
Total TN	258182	>	257594
Total FP	269	<	1119
Total FP CONTRA	10	<	123
Total FP INCONS	212	<	791
Total FP COMP	47	<	205
Total FN	838	<	942
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CMfinder(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	656
Total TN	258182
Total FP	269
Total FP CONTRA	10
Total FP INCONS	212
Total FP COMP	47
Total FN	838

Total Scores
MCC	0.571
Average MCC ± 95% Confidence Intervals	0.537 ± 0.067
Sensitivity	0.439
Positive Predictive Value	0.747
Nr of predictions	78

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	2	0	0	2	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.85	0.73	1.00	30	5020	0	0	0	0	11
PDB_00553	mir-TAR links to Rfam database...	0.00	0.00	0.00	0	465	0	0	0	0	11
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00810	s2m links to Rfam database...	0.76	0.59	1.00	10	1071	0	0	0	0	7
PDB_01050	UnaL2 links to Rfam database...	0.68	0.46	1.00	6	624	1	0	0	1	7
PDB_01051	Telomerase-cil links to Rfam database...	0.83	0.69	1.00	9	894	4	0	0	4	4
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
PDB_01152	HIV_FS2 links to Rfam database...	0.92	0.86	1.00	12	549	0	0	0	0	2
RFA_00603	Telomerase-cil links to Rfam database...	0.70	0.60	0.81	21	13504	7	0	5	2	14
RFA_00604	Telomerase-cil links to Rfam database...	0.63	0.51	0.78	18	13507	8	0	5	3	17
RFA_00605	Telomerase-cil links to Rfam database...	0.14	0.06	0.33	2	15219	5	0	4	1	33
RFA_00607	Telomerase-cil links to Rfam database...	0.08	0.06	0.13	2	17750	15	3	11	1	34
RFA_00609	Telomerase-cil links to Rfam database...	0.32	0.22	0.47	8	17938	12	2	7	3	29
RFA_00610	Telomerase-cil links to Rfam database...	0.39	0.30	0.52	11	17184	13	2	8	3	26
RFA_00611	Telomerase-cil links to Rfam database...	0.65	0.51	0.82	18	13019	5	0	4	1	17
RFA_00613	Telomerase-cil links to Rfam database...	0.70	0.57	0.87	20	12857	4	0	3	1	15
RFA_00615	Telomerase-cil links to Rfam database...	0.57	0.49	0.68	17	13341	10	0	8	2	18
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00642	Vimentin3 links to Rfam database...	0.44	0.28	0.71	5	2919	2	0	2	0	13
RFA_00643	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2203	8	0	8	0	18
RFA_00644	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2693	8	0	8	0	18
RFA_00645	Vimentin3 links to Rfam database...	0.29	0.17	0.50	3	2409	3	0	3	0	15
RFA_00649	Vimentin3 links to Rfam database...	0.35	0.22	0.57	4	2138	3	0	3	0	14
RFA_00651	Vimentin3 links to Rfam database...	0.35	0.22	0.57	4	2073	3	0	3	0	14
RFA_00653	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2137	8	0	8	0	18
RFA_00654	Vimentin3 links to Rfam database...	0.38	0.22	0.67	4	2409	2	0	2	0	14
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00659	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00667	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00668	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00672	Hammerhead_1 links to Rfam database...	0.41	0.31	0.57	4	896	3	0	3	0	9
RFA_00673	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00674	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00675	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00677	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00678	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00680	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00684	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	984	3	0	2	1	10
RFA_00685	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00704	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00705	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00706	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00707	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00709	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00710	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	3	0	3	0	11
RFA_00711	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00715	Hammerhead_1 links to Rfam database...	0.30	0.14	0.67	2	943	2	0	1	1	12
RFA_00716	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00717	Hammerhead_1 links to Rfam database...	0.30	0.21	0.43	3	896	4	0	4	0	11
RFA_00730	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00731	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00733	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00734	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00736	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00737	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00745	s2m links to Rfam database...	0.91	0.83	1.00	10	936	0	0	0	0	2
RFA_00749	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00758	s2m links to Rfam database...	0.86	0.75	1.00	9	894	0	0	0	0	3
RFA_00762	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00763	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00764	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00765	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00781	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00786	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3
RFA_00791	Gammaretro_CES links to Rfam database...	0.92	0.88	0.97	28	5122	1	0	1	0	4
RFA_00792	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00801	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP	552
Total TN	257594
Total FP	1119
Total FP CONTRA	123
Total FP INCONS	791
Total FP COMP	205
Total FN	942

Total Scores
MCC	0.369
Average MCC ± 95% Confidence Intervals	0.371 ± 0.063
Sensitivity	0.369
Positive Predictive Value	0.377
Nr of predictions	78

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.42	0.36	0.50	5	936	6	0	5	1	9
PDB_00012	mir-TAR links to Rfam database...	0.92	0.86	1.00	6	400	2	0	0	2	1
PDB_00213	Gammaretro_CES links to Rfam database...	0.84	0.83	0.85	34	5010	7	0	6	1	7
PDB_00553	mir-TAR links to Rfam database...	0.90	0.82	1.00	9	456	0	0	0	0	2
PDB_00716	HDV_ribozyme links to Rfam database...	0.68	0.57	0.81	13	2685	3	0	3	0	10
PDB_00810	s2m links to Rfam database...	0.55	0.47	0.67	8	1069	4	0	4	0	9
PDB_01050	UnaL2 links to Rfam database...	0.80	0.77	0.83	10	618	2	0	2	0	3
PDB_01051	Telomerase-cil links to Rfam database...	1.00	1.00	1.00	13	890	5	0	0	5	0
PDB_01092	glmS links to Rfam database...	0.43	0.38	0.49	20	10112	23	2	19	2	32
PDB_01152	HIV_FS2 links to Rfam database...	0.92	0.86	1.00	12	549	1	0	0	1	2
RFA_00603	Telomerase-cil links to Rfam database...	0.55	0.60	0.50	21	13488	33	5	16	12	14
RFA_00604	Telomerase-cil links to Rfam database...	0.73	0.77	0.69	27	13491	29	5	7	17	8
RFA_00605	Telomerase-cil links to Rfam database...	0.15	0.17	0.14	6	15181	46	6	32	8	29
RFA_00607	Telomerase-cil links to Rfam database...	0.44	0.44	0.44	16	17730	39	1	19	19	20
RFA_00609	Telomerase-cil links to Rfam database...	0.59	0.62	0.56	23	17914	37	1	17	19	14
RFA_00610	Telomerase-cil links to Rfam database...	0.09	0.11	0.08	4	17154	53	17	30	6	33
RFA_00611	Telomerase-cil links to Rfam database...	0.65	0.69	0.62	24	13002	29	3	12	14	11
RFA_00613	Telomerase-cil links to Rfam database...	0.16	0.17	0.15	6	12839	41	8	27	6	29
RFA_00615	Telomerase-cil links to Rfam database...	0.10	0.11	0.09	4	13321	42	10	31	1	31
RFA_00632	HDV_ribozyme links to Rfam database...	0.25	0.25	0.27	7	4069	22	1	18	3	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.40	0.39	0.41	11	3978	19	1	15	3	17
RFA_00642	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2906	20	2	18	0	18
RFA_00643	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2190	21	4	17	0	18
RFA_00644	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2682	21	0	19	2	18
RFA_00645	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2396	19	4	15	0	18
RFA_00649	Vimentin3 links to Rfam database...	0.42	0.44	0.40	8	2125	14	1	11	2	10
RFA_00651	Vimentin3 links to Rfam database...	0.10	0.11	0.11	2	2061	17	1	16	0	16
RFA_00653	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2123	22	4	18	0	18
RFA_00654	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2394	21	3	18	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.56	0.50	0.64	7	1117	8	0	4	4	7
RFA_00659	Hammerhead_1 links to Rfam database...	0.20	0.21	0.21	3	1114	14	1	10	3	11
RFA_00664	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	974	16	0	16	0	14
RFA_00667	Hammerhead_1 links to Rfam database...	0.27	0.29	0.27	4	975	12	1	10	1	10
RFA_00668	Hammerhead_1 links to Rfam database...	0.44	0.43	0.46	6	977	7	0	7	0	8
RFA_00672	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	893	12	0	10	2	13
RFA_00673	Hammerhead_1 links to Rfam database...	0.36	0.36	0.38	5	1115	10	0	8	2	9
RFA_00674	Hammerhead_1 links to Rfam database...	0.74	0.71	0.77	10	1115	5	0	3	2	4
RFA_00675	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	979	13	0	11	2	14
RFA_00677	Hammerhead_1 links to Rfam database...	0.55	0.57	0.53	8	975	10	0	7	3	6
RFA_00678	Hammerhead_1 links to Rfam database...	0.30	0.29	0.33	4	934	10	0	8	2	10
RFA_00680	Hammerhead_1 links to Rfam database...	0.42	0.43	0.43	6	1114	12	0	8	4	8
RFA_00684	Hammerhead_1 links to Rfam database...	0.37	0.29	0.50	4	982	4	1	3	0	10
RFA_00685	Hammerhead_1 links to Rfam database...	0.46	0.43	0.50	6	978	6	2	4	0	8
RFA_00704	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	979	11	2	9	0	14
RFA_00705	Hammerhead_1 links to Rfam database...	0.69	0.71	0.67	10	1020	6	0	5	1	4
RFA_00706	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1023	12	2	10	0	14
RFA_00707	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1025	11	0	10	1	14
RFA_00708	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1025	10	1	9	0	14
RFA_00709	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	978	12	0	12	0	14
RFA_00710	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	978	12	1	11	0	14
RFA_00711	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1022	14	2	11	1	14
RFA_00715	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	936	10	0	10	0	14
RFA_00716	Hammerhead_1 links to Rfam database...	0.06	0.07	0.07	1	932	13	0	13	0	13
RFA_00717	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	891	4	0	3	1	5
RFA_00730	s2m links to Rfam database...	0.48	0.42	0.56	5	894	6	0	4	2	7
RFA_00731	s2m links to Rfam database...	0.55	0.58	0.54	7	890	9	1	5	3	5
RFA_00733	s2m links to Rfam database...	0.23	0.25	0.23	3	890	12	1	9	2	9
RFA_00734	s2m links to Rfam database...	0.52	0.50	0.55	6	892	7	0	5	2	6
RFA_00736	s2m links to Rfam database...	0.48	0.42	0.56	5	894	7	0	4	3	7
RFA_00737	s2m links to Rfam database...	0.34	0.33	0.36	4	892	9	2	5	2	8
RFA_00745	s2m links to Rfam database...	0.66	0.67	0.67	8	934	8	0	4	4	4
RFA_00749	s2m links to Rfam database...	0.55	0.58	0.54	7	890	9	1	5	3	5
RFA_00758	s2m links to Rfam database...	0.45	0.42	0.50	5	893	5	0	5	0	7
RFA_00762	s2m links to Rfam database...	0.55	0.58	0.54	7	890	9	1	5	3	5
RFA_00763	s2m links to Rfam database...	0.58	0.58	0.58	7	891	8	0	5	3	5
RFA_00764	s2m links to Rfam database...	0.48	0.42	0.56	5	894	6	0	4	2	7
RFA_00765	s2m links to Rfam database...	0.36	0.42	0.33	5	888	13	0	10	3	7
RFA_00769	Corona_pk3 links to Rfam database...	0.41	0.44	0.38	8	1932	13	3	10	0	10
RFA_00770	Corona_pk3 links to Rfam database...	0.51	0.50	0.53	9	1999	12	2	6	4	9
RFA_00773	Corona_pk3 links to Rfam database...	0.42	0.39	0.47	7	1938	12	1	7	4	11
RFA_00779	Corona_pk3 links to Rfam database...	0.26	0.28	0.26	5	1934	14	6	8	0	13
RFA_00781	Gammaretro_CES links to Rfam database...	0.72	0.72	0.72	23	5018	13	0	9	4	9
RFA_00786	Gammaretro_CES links to Rfam database...	0.32	0.31	0.34	10	5021	22	2	17	3	22
RFA_00791	Gammaretro_CES links to Rfam database...	0.41	0.44	0.39	14	5115	23	5	17	1	18
RFA_00792	Gammaretro_CES links to Rfam database...	0.18	0.16	0.21	5	5026	20	2	17	1	27
RFA_00801	Gammaretro_CES links to Rfam database...	0.31	0.31	0.32	10	5019	22	2	19	1	22
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	2	0	0	7
RFA_00809	RydC links to Rfam database...	0.47	0.38	0.60	6	2135	6	0	4	2	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

2. Individual counts for RNAwolf [ download as .csv ]