CompaRNA - on-line benchmarks of RNA structure prediction methods

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Overview

Metric	CMfinder(seed)		Vsfold4
MCC	0.571	>	0.403
Average MCC ± 95% Confidence Intervals	0.537 ± 0.067	>	0.387 ± 0.065
Sensitivity	0.439	>	0.355
Positive Predictive Value	0.747	>	0.464
Total TP	656	>	531
Total TN	258182	>	257916
Total FP	269	<	704
Total FP CONTRA	10	<	81
Total FP INCONS	212	<	532
Total FP COMP	47	<	91
Total FN	838	<	963
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CMfinder(seed) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold4).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold4).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold4).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	656
Total TN	258182
Total FP	269
Total FP CONTRA	10
Total FP INCONS	212
Total FP COMP	47
Total FN	838

Total Scores
MCC	0.571
Average MCC ± 95% Confidence Intervals	0.537 ± 0.067
Sensitivity	0.439
Positive Predictive Value	0.747
Nr of predictions	78

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	2	0	0	2	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.85	0.73	1.00	30	5020	0	0	0	0	11
PDB_00553	mir-TAR links to Rfam database...	0.00	0.00	0.00	0	465	0	0	0	0	11
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00810	s2m links to Rfam database...	0.76	0.59	1.00	10	1071	0	0	0	0	7
PDB_01050	UnaL2 links to Rfam database...	0.68	0.46	1.00	6	624	1	0	0	1	7
PDB_01051	Telomerase-cil links to Rfam database...	0.83	0.69	1.00	9	894	4	0	0	4	4
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
PDB_01152	HIV_FS2 links to Rfam database...	0.92	0.86	1.00	12	549	0	0	0	0	2
RFA_00603	Telomerase-cil links to Rfam database...	0.70	0.60	0.81	21	13504	7	0	5	2	14
RFA_00604	Telomerase-cil links to Rfam database...	0.63	0.51	0.78	18	13507	8	0	5	3	17
RFA_00605	Telomerase-cil links to Rfam database...	0.14	0.06	0.33	2	15219	5	0	4	1	33
RFA_00607	Telomerase-cil links to Rfam database...	0.08	0.06	0.13	2	17750	15	3	11	1	34
RFA_00609	Telomerase-cil links to Rfam database...	0.32	0.22	0.47	8	17938	12	2	7	3	29
RFA_00610	Telomerase-cil links to Rfam database...	0.39	0.30	0.52	11	17184	13	2	8	3	26
RFA_00611	Telomerase-cil links to Rfam database...	0.65	0.51	0.82	18	13019	5	0	4	1	17
RFA_00613	Telomerase-cil links to Rfam database...	0.70	0.57	0.87	20	12857	4	0	3	1	15
RFA_00615	Telomerase-cil links to Rfam database...	0.57	0.49	0.68	17	13341	10	0	8	2	18
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00642	Vimentin3 links to Rfam database...	0.44	0.28	0.71	5	2919	2	0	2	0	13
RFA_00643	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2203	8	0	8	0	18
RFA_00644	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2693	8	0	8	0	18
RFA_00645	Vimentin3 links to Rfam database...	0.29	0.17	0.50	3	2409	3	0	3	0	15
RFA_00649	Vimentin3 links to Rfam database...	0.35	0.22	0.57	4	2138	3	0	3	0	14
RFA_00651	Vimentin3 links to Rfam database...	0.35	0.22	0.57	4	2073	3	0	3	0	14
RFA_00653	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2137	8	0	8	0	18
RFA_00654	Vimentin3 links to Rfam database...	0.38	0.22	0.67	4	2409	2	0	2	0	14
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00659	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00667	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00668	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00672	Hammerhead_1 links to Rfam database...	0.41	0.31	0.57	4	896	3	0	3	0	9
RFA_00673	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00674	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00675	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00677	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00678	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00680	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00684	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	984	3	0	2	1	10
RFA_00685	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00704	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00705	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00706	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00707	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00709	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00710	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	3	0	3	0	11
RFA_00711	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00715	Hammerhead_1 links to Rfam database...	0.30	0.14	0.67	2	943	2	0	1	1	12
RFA_00716	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00717	Hammerhead_1 links to Rfam database...	0.30	0.21	0.43	3	896	4	0	4	0	11
RFA_00730	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00731	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00733	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00734	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00736	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00737	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00745	s2m links to Rfam database...	0.91	0.83	1.00	10	936	0	0	0	0	2
RFA_00749	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00758	s2m links to Rfam database...	0.86	0.75	1.00	9	894	0	0	0	0	3
RFA_00762	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00763	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00764	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00765	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00779	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00781	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00786	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3
RFA_00791	Gammaretro_CES links to Rfam database...	0.92	0.88	0.97	28	5122	1	0	1	0	4
RFA_00792	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00801	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	531
Total TN	257916
Total FP	704
Total FP CONTRA	81
Total FP INCONS	532
Total FP COMP	91
Total FN	963

Total Scores
MCC	0.403
Average MCC ± 95% Confidence Intervals	0.387 ± 0.065
Sensitivity	0.355
Positive Predictive Value	0.464
Nr of predictions	78

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00005	Tymo_tRNA-like links to Rfam database...	0.84	0.71	1.00	10	936	0	0	0	0	4
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.46	0.41	0.52	17	5017	16	0	16	0	24
PDB_00553	mir-TAR links to Rfam database...	1.00	1.00	1.00	11	454	0	0	0	0	0
PDB_00716	HDV_ribozyme links to Rfam database...	0.17	0.17	0.18	4	2679	19	0	18	1	19
PDB_00810	s2m links to Rfam database...	0.45	0.35	0.60	6	1071	4	2	2	0	11
PDB_01050	UnaL2 links to Rfam database...	0.92	0.85	1.00	11	619	2	0	0	2	2
PDB_01051	Telomerase-cil links to Rfam database...	0.36	0.38	0.36	5	889	9	2	7	0	8
PDB_01092	glmS links to Rfam database...	0.66	0.58	0.77	30	10114	10	2	7	1	22
PDB_01152	HIV_FS2 links to Rfam database...	0.88	0.79	1.00	11	550	0	0	0	0	3
RFA_00603	Telomerase-cil links to Rfam database...	0.30	0.29	0.32	10	13499	21	5	16	0	25
RFA_00604	Telomerase-cil links to Rfam database...	0.52	0.49	0.57	17	13500	18	8	5	5	18
RFA_00605	Telomerase-cil links to Rfam database...	0.19	0.17	0.22	6	15198	33	3	18	12	29
RFA_00607	Telomerase-cil links to Rfam database...	0.61	0.56	0.67	20	17736	23	2	8	13	16
RFA_00609	Telomerase-cil links to Rfam database...	0.56	0.59	0.54	22	17914	27	4	15	8	15
RFA_00610	Telomerase-cil links to Rfam database...	0.64	0.65	0.63	24	17167	23	2	12	9	13
RFA_00611	Telomerase-cil links to Rfam database...	0.56	0.54	0.58	19	13008	17	3	11	3	16
RFA_00613	Telomerase-cil links to Rfam database...	0.27	0.26	0.29	9	12849	25	5	17	3	26
RFA_00615	Telomerase-cil links to Rfam database...	0.31	0.29	0.34	10	13337	19	7	12	0	25
RFA_00632	HDV_ribozyme links to Rfam database...	0.36	0.36	0.37	10	4068	17	3	14	0	18
RFA_00636	HDV_ribozyme links to Rfam database...	0.58	0.57	0.59	16	3978	11	1	10	0	12
RFA_00642	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2915	11	1	10	0	18
RFA_00643	Vimentin3 links to Rfam database...	0.45	0.39	0.54	7	2198	6	0	6	0	11
RFA_00644	Vimentin3 links to Rfam database...	0.22	0.22	0.22	4	2683	14	1	13	0	14
RFA_00645	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2404	11	0	11	0	18
RFA_00649	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2130	15	1	14	0	18
RFA_00651	Vimentin3 links to Rfam database...	0.41	0.39	0.44	7	2064	9	1	8	0	11
RFA_00653	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2134	11	0	11	0	18
RFA_00654	Vimentin3 links to Rfam database...	0.54	0.44	0.67	8	2403	5	1	3	1	10
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	5	0	3	2	10
RFA_00659	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1122	8	0	6	2	14
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00667	Hammerhead_1 links to Rfam database...	0.22	0.21	0.25	3	978	10	1	8	1	11
RFA_00668	Hammerhead_1 links to Rfam database...	0.40	0.36	0.45	5	979	6	0	6	0	9
RFA_00672	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	897	6	0	6	0	13
RFA_00673	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00674	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1118	10	0	10	0	14
RFA_00675	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	981	9	1	8	0	14
RFA_00677	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	979	5	0	3	2	6
RFA_00678	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	940	3	0	3	0	11
RFA_00680	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	1116	6	0	3	3	5
RFA_00684	Hammerhead_1 links to Rfam database...	0.75	0.57	1.00	8	982	1	0	0	1	6
RFA_00685	Hammerhead_1 links to Rfam database...	0.35	0.29	0.44	4	981	6	0	5	1	10
RFA_00704	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	983	8	0	7	1	14
RFA_00705	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	1023	4	0	3	1	5
RFA_00706	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1024	11	2	9	0	14
RFA_00707	Hammerhead_1 links to Rfam database...	0.31	0.29	0.36	4	1024	7	0	7	0	10
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	4	0	3	1	10
RFA_00709	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	985	6	0	5	1	14
RFA_00710	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	10	0	10	0	14
RFA_00711	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	1026	9	0	9	0	14
RFA_00715	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	937	9	0	9	0	14
RFA_00716	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	936	10	0	10	0	14
RFA_00717	Hammerhead_1 links to Rfam database...	0.39	0.36	0.45	5	892	6	0	6	0	9
RFA_00730	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00731	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00733	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00734	s2m links to Rfam database...	0.34	0.33	0.36	4	892	7	2	5	0	8
RFA_00736	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00737	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00745	s2m links to Rfam database...	-0.01	0.00	0.00	0	941	5	1	4	0	12
RFA_00749	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00758	s2m links to Rfam database...	-0.01	0.00	0.00	0	898	5	0	5	0	12
RFA_00762	s2m links to Rfam database...	0.39	0.42	0.38	5	890	8	2	6	0	7
RFA_00763	s2m links to Rfam database...	0.64	0.42	1.00	5	898	0	0	0	0	7
RFA_00764	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00765	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00769	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	4	5	0	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	2003	15	2	11	2	18
RFA_00773	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1936	19	1	16	2	18
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	2	1	0	8
RFA_00781	Gammaretro_CES links to Rfam database...	0.56	0.53	0.59	17	5021	12	1	11	0	15
RFA_00786	Gammaretro_CES links to Rfam database...	0.39	0.34	0.44	11	5025	14	1	13	0	21
RFA_00791	Gammaretro_CES links to Rfam database...	0.41	0.34	0.50	11	5129	11	1	10	0	21
RFA_00792	Gammaretro_CES links to Rfam database...	0.57	0.53	0.61	17	5022	11	0	11	0	15
RFA_00801	Gammaretro_CES links to Rfam database...	0.53	0.50	0.57	16	5022	12	2	10	0	16
RFA_00808	RydC links to Rfam database...	0.62	0.56	0.69	9	2003	4	3	1	0	7
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]