CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CRWrnafold - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CRWrnafold & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric CRWrnafold Murlet(seed)
MCC 0.516 > 0.468
Average MCC ± 95% Confidence Intervals 0.492 ± 0.066 > 0.340 ± 0.080
Sensitivity 0.496 > 0.266
Positive Predictive Value 0.543 < 0.828
Total TP 885 > 475
Total TN 306678 < 307733
Total FP 928 > 103
Total FP CONTRA 122 > 0
Total FP INCONS 622 > 99
Total FP COMP 184 > 4
Total FN 901 < 1311
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CRWrnafold and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CRWrnafold and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CRWrnafold and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CRWrnafold and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CRWrnafold and Murlet(seed)).

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Performance of CRWrnafold - scored higher in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 885
Total TN 306678
Total FP 928
Total FP CONTRA 122
Total FP INCONS 622
Total FP COMP 184
Total FN 901
Total Scores
MCC 0.516
Average MCC ± 95% Confidence Intervals 0.492 ± 0.066
Sensitivity 0.496
Positive Predictive Value 0.543
Nr of predictions 91

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.92 0.85 1.00 35 5015 0 0 0 0 6
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 -0.01 0.00 0.00 0 2680 22 0 21 1 23
PDB_00810 0.67 0.59 0.77 10 1068 3 0 3 0 7
PDB_01050 0.92 0.85 1.00 11 619 1 0 0 1 2
PDB_01051 0.79 0.69 0.90 9 893 5 0 1 4 4
PDB_01092 0.68 0.62 0.76 32 10111 12 1 9 2 20
PDB_01152 0.88 0.79 1.00 11 550 0 0 0 0 3
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00416 1.00 1.00 1.00 15 1470 3 0 0 3 0
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00587 1.00 1.00 1.00 15 4836 12 0 0 12 0
RFA_00603 0.27 0.29 0.26 10 13491 31 8 21 2 25
RFA_00604 0.61 0.63 0.59 22 13493 26 2 13 11 13
RFA_00605 0.34 0.34 0.34 12 15190 36 4 19 13 23
RFA_00607 0.29 0.31 0.28 11 17726 39 5 24 10 25
RFA_00609 0.52 0.57 0.48 21 17911 36 8 15 13 16
RFA_00610 0.52 0.54 0.50 20 17165 33 4 16 13 17
RFA_00611 0.45 0.49 0.43 17 13001 27 8 15 4 18
RFA_00613 0.43 0.43 0.44 15 12846 26 8 11 7 20
RFA_00615 0.27 0.29 0.26 10 13328 29 7 21 1 25
RFA_00632 0.37 0.36 0.38 10 4069 19 0 16 3 18
RFA_00636 0.51 0.50 0.52 14 3978 13 3 10 0 14
RFA_00642 0.17 0.17 0.18 3 2909 17 0 14 3 15
RFA_00643 0.24 0.22 0.27 4 2196 12 2 9 1 14
RFA_00644 0.21 0.22 0.21 4 2682 15 4 11 0 14
RFA_00645 -0.01 0.00 0.00 0 2401 14 2 12 0 18
RFA_00649 0.57 0.56 0.59 10 2128 7 1 6 0 8
RFA_00651 0.35 0.33 0.38 6 2064 10 1 9 0 12
RFA_00653 0.35 0.33 0.38 6 2129 10 2 8 0 12
RFA_00654 0.26 0.28 0.26 5 2396 14 2 12 0 13
RFA_00658 0.59 0.50 0.70 7 1118 4 0 3 1 7
RFA_00659 0.18 0.14 0.25 2 1120 8 0 6 2 12
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 0.30 0.29 0.33 4 978 9 1 7 1 10
RFA_00668 0.46 0.43 0.50 6 978 6 0 6 0 8
RFA_00672 -0.01 0.00 0.00 0 897 6 0 6 0 13
RFA_00673 0.47 0.36 0.63 5 1120 4 0 3 1 9
RFA_00674 -0.01 0.00 0.00 0 1118 10 0 10 0 14
RFA_00675 0.29 0.29 0.31 4 977 9 1 8 0 10
RFA_00677 0.69 0.64 0.75 9 978 5 0 3 2 5
RFA_00678 -0.01 0.00 0.00 0 941 5 0 5 0 14
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.72 0.64 0.82 9 979 3 0 2 1 5
RFA_00685 0.42 0.36 0.50 5 980 6 0 5 1 9
RFA_00695 0.67 0.64 0.69 9 7008 28 1 3 24 5
RFA_00703 0.67 0.64 0.69 9 4265 18 1 3 14 5
RFA_00704 -0.01 0.00 0.00 0 981 10 0 9 1 14
RFA_00705 0.74 0.71 0.77 10 1022 4 0 3 1 4
RFA_00706 0.33 0.29 0.40 4 1025 6 0 6 0 10
RFA_00707 -0.01 0.00 0.00 0 1024 11 3 8 0 14
RFA_00708 0.35 0.29 0.44 4 1026 6 0 5 1 10
RFA_00709 -0.01 0.00 0.00 0 982 9 0 8 1 14
RFA_00710 -0.01 0.00 0.00 0 980 10 0 10 0 14
RFA_00711 -0.01 0.00 0.00 0 1024 11 0 11 0 14
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 939 7 0 7 0 14
RFA_00717 0.31 0.29 0.36 4 892 8 0 7 1 10
RFA_00730 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00731 0.41 0.42 0.42 5 891 8 3 4 1 7
RFA_00733 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00734 0.64 0.67 0.62 8 890 5 1 4 0 4
RFA_00736 0.41 0.42 0.42 5 891 8 3 4 1 7
RFA_00737 0.81 0.67 1.00 8 895 1 0 0 1 4
RFA_00745 0.69 0.67 0.73 8 935 4 1 2 1 4
RFA_00749 0.41 0.42 0.42 5 891 8 3 4 1 7
RFA_00758 0.63 0.58 0.70 7 893 3 1 2 0 5
RFA_00762 0.64 0.67 0.62 8 890 5 1 4 0 4
RFA_00763 0.69 0.67 0.73 8 892 3 1 2 0 4
RFA_00764 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00765 0.81 0.67 1.00 8 895 1 0 0 1 4
RFA_00767 0.59 0.56 0.63 10 1875 6 3 3 0 8
RFA_00768 0.47 0.44 0.50 8 1875 8 1 7 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 -0.01 0.00 0.00 0 2002 17 1 13 3 18
RFA_00773 0.59 0.56 0.63 10 1937 6 1 5 0 8
RFA_00779 0.59 0.56 0.63 10 1937 6 3 3 0 8
RFA_00781 0.74 0.75 0.73 24 5017 9 2 7 0 8
RFA_00786 0.17 0.16 0.19 5 5024 21 1 20 0 27
RFA_00791 0.46 0.44 0.48 14 5122 15 0 15 0 18
RFA_00792 0.94 0.94 0.94 30 5018 4 0 2 2 2
RFA_00801 0.38 0.34 0.42 11 5024 16 1 14 1 21
RFA_00808 -0.01 0.00 0.00 0 2000 18 2 14 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10
SRP_00137 0.75 0.84 0.68 21 4155 10 4 6 0 4
SRP_00141 0.92 0.93 0.90 38 6286 4 1 3 0 3
SRP_00146 0.92 0.92 0.92 33 5217 3 1 2 0 3
SRP_00285 0.98 0.97 1.00 29 3712 0 0 0 0 1
SRP_00338 0.96 0.94 0.97 34 5425 1 0 1 0 2

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 475
Total TN 307733
Total FP 103
Total FP CONTRA 0
Total FP INCONS 99
Total FP COMP 4
Total FN 1311
Total Scores
MCC 0.468
Average MCC ± 95% Confidence Intervals 0.340 ± 0.080
Sensitivity 0.266
Positive Predictive Value 0.828
Nr of predictions 91

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00012 0.65 0.43 1.00 3 403 0 0 0 0 4
PDB_00213 0.73 0.59 0.92 24 5024 2 0 2 0 17
PDB_00553 0.45 0.27 0.75 3 461 1 0 1 0 8
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_00810 0.63 0.53 0.75 9 1069 3 0 3 0 8
PDB_01050 0.55 0.31 1.00 4 626 1 0 0 1 9
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
PDB_01152 0.76 0.64 0.90 9 551 1 0 1 0 5
RFA_00390 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00416 0.00 0.00 0.00 0 1485 0 0 0 0 15
RFA_00433 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00604 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00605 0.00 0.00 0.00 0 15225 0 0 0 0 35
RFA_00607 0.00 0.00 0.00 0 17766 0 0 0 0 36
RFA_00609 0.00 0.00 0.00 0 17955 0 0 0 0 37
RFA_00610 0.00 0.00 0.00 0 17205 0 0 0 0 37
RFA_00611 0.00 0.00 0.00 0 13041 0 0 0 0 35
RFA_00613 0.00 0.00 0.00 0 12880 0 0 0 0 35
RFA_00615 0.00 0.00 0.00 0 13366 0 0 0 0 35
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00642 0.57 0.44 0.73 8 2915 3 0 3 0 10
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.42 0.33 0.55 6 2690 5 0 5 0 12
RFA_00645 0.00 0.00 0.00 0 2407 8 0 8 0 18
RFA_00649 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00651 0.42 0.33 0.55 6 2069 5 0 5 0 12
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.57 0.44 0.73 8 2404 3 0 3 0 10
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00659 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00668 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00684 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00685 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00706 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00707 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00710 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00711 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00715 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00731 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00733 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00734 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00736 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00737 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00745 1.00 1.00 1.00 12 934 0 0 0 0 0
RFA_00749 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00758 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00762 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00767 0.47 0.33 0.67 6 1882 3 0 3 0 12
RFA_00768 0.41 0.28 0.63 5 1883 3 0 3 0 13
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00781 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00786 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00791 0.83 0.75 0.92 24 5125 2 0 2 0 8
RFA_00792 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00801 0.80 0.72 0.88 23 5024 3 0 3 0 9
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10
SRP_00137 0.49 0.24 1.00 6 4180 0 0 0 0 19
SRP_00141 0.35 0.12 1.00 5 6323 1 0 0 1 36
SRP_00146 0.41 0.17 1.00 6 5247 0 0 0 0 30
SRP_00285 0.45 0.20 1.00 6 3735 0 0 0 0 24
SRP_00338 0.41 0.17 1.00 6 5454 0 0 0 0 30

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.