CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Contrafold Carnac(seed)
MCC 0.665 > 0.415
Average MCC ± 95% Confidence Intervals 0.624 ± 0.057 > 0.323 ± 0.066
Sensitivity 0.633 > 0.196
Positive Predictive Value 0.702 < 0.884
Total TP 1656 > 512
Total TN 436189 < 437968
Total FP 983 > 145
Total FP CONTRA 100 > 14
Total FP INCONS 602 > 53
Total FP COMP 281 > 78
Total FN 959 < 2103
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Carnac(seed)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1656
Total TN 436189
Total FP 983
Total FP CONTRA 100
Total FP INCONS 602
Total FP COMP 281
Total FN 959
Total Scores
MCC 0.665
Average MCC ± 95% Confidence Intervals 0.624 ± 0.057
Sensitivity 0.633
Positive Predictive Value 0.702
Nr of predictions 123

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01484 0.18 0.18 0.19 7 7467 30 4 25 1 32
CRW_01499 0.70 0.61 0.81 25 7970 8 0 6 2 16
CRW_01603 0.86 0.81 0.91 30 7107 5 0 3 2 7
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.94 0.88 1.00 36 5014 0 0 0 0 5
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 0.33 0.30 0.37 7 2682 13 0 12 1 16
PDB_00810 0.77 0.71 0.86 12 1067 3 0 2 1 5
PDB_01001 0.49 0.56 0.43 10 2122 13 3 10 0 8
PDB_01050 0.96 0.92 1.00 12 618 2 0 0 2 1
PDB_01051 0.88 0.85 0.92 11 891 5 0 1 4 2
PDB_01092 0.70 0.65 0.76 34 10108 14 2 9 3 18
PDB_01152 0.96 0.93 1.00 13 548 0 0 0 0 1
RFA_00389 0.93 0.93 0.93 14 1416 4 0 1 3 1
RFA_00390 1.00 1.00 1.00 15 1416 3 0 0 3 0
RFA_00391 0.62 0.60 0.64 9 1417 7 2 3 2 6
RFA_00409 0.62 0.60 0.64 9 1417 6 1 4 1 6
RFA_00416 1.00 1.00 1.00 15 1470 3 0 0 3 0
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00440 1.00 1.00 1.00 15 1470 3 0 0 3 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 5 0 0 5 1
RFA_00449 0.73 0.60 0.90 9 1475 3 0 1 2 6
RFA_00587 1.00 1.00 1.00 15 4836 10 0 0 10 0
RFA_00603 0.73 0.71 0.76 25 13497 8 4 4 0 10
RFA_00604 0.71 0.74 0.68 26 13492 26 2 10 14 9
RFA_00605 0.35 0.34 0.36 12 15192 35 2 19 14 23
RFA_00607 0.87 0.81 0.94 29 17735 11 0 2 9 7
RFA_00609 0.76 0.78 0.74 29 17916 27 2 8 17 8
RFA_00610 0.90 0.86 0.94 32 17171 20 0 2 18 5
RFA_00611 0.82 0.74 0.90 26 13012 6 0 3 3 9
RFA_00613 0.60 0.51 0.69 18 12854 9 3 5 1 17
RFA_00615 0.63 0.57 0.69 20 13337 9 4 5 0 15
RFA_00632 0.38 0.39 0.37 11 4065 19 0 19 0 17
RFA_00636 0.60 0.64 0.56 18 3973 14 4 10 0 10
RFA_00642 0.00 0.00 0.00 0 2915 11 2 9 0 18
RFA_00643 -0.01 0.00 0.00 0 2202 9 1 8 0 18
RFA_00644 0.00 0.00 0.00 0 2692 9 1 8 0 18
RFA_00645 -0.01 0.00 0.00 0 2402 13 3 10 0 18
RFA_00649 0.26 0.22 0.31 4 2132 9 6 3 0 14
RFA_00651 0.40 0.33 0.50 6 2068 6 1 5 0 12
RFA_00653 -0.01 0.00 0.00 0 2133 12 2 10 0 18
RFA_00654 -0.01 0.00 0.00 0 2400 15 2 13 0 18
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00659 -0.01 0.00 0.00 0 1120 10 1 7 2 14
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 0.29 0.29 0.31 4 977 10 1 8 1 10
RFA_00668 0.53 0.43 0.67 6 981 3 0 3 0 8
RFA_00672 -0.01 0.00 0.00 0 897 6 0 6 0 13
RFA_00673 0.42 0.36 0.50 5 1118 6 0 5 1 9
RFA_00674 0.96 0.93 1.00 13 1115 1 0 0 1 1
RFA_00675 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00677 0.59 0.57 0.62 8 977 7 0 5 2 6
RFA_00678 0.53 0.29 1.00 4 942 0 0 0 0 10
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00685 0.44 0.36 0.56 5 981 4 0 4 0 9
RFA_00695 0.44 0.36 0.56 5 7012 29 1 3 25 9
RFA_00703 0.67 0.64 0.69 9 4265 19 1 3 15 5
RFA_00704 0.32 0.21 0.50 3 984 5 0 3 2 11
RFA_00705 0.74 0.71 0.77 10 1022 4 0 3 1 4
RFA_00706 0.37 0.29 0.50 4 1027 4 0 4 0 10
RFA_00707 -0.01 0.00 0.00 0 1027 8 1 7 0 14
RFA_00708 0.40 0.29 0.57 4 1028 3 0 3 0 10
RFA_00709 -0.01 0.00 0.00 0 981 10 0 9 1 14
RFA_00710 -0.01 0.00 0.00 0 979 11 0 11 0 14
RFA_00711 -0.01 0.00 0.00 0 1026 9 0 9 0 14
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 937 9 0 9 0 14
RFA_00717 0.66 0.64 0.69 9 890 4 0 4 0 5
RFA_00730 0.75 0.75 0.75 9 891 5 0 3 2 3
RFA_00731 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00733 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00734 0.83 0.83 0.83 10 891 5 0 2 3 2
RFA_00736 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00737 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00745 0.66 0.67 0.67 8 934 6 1 3 2 4
RFA_00749 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00758 0.60 0.58 0.64 7 892 5 1 3 1 5
RFA_00762 0.64 0.67 0.62 8 890 6 1 4 1 4
RFA_00763 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00764 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00765 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00767 0.74 0.56 1.00 10 1881 2 0 0 2 8
RFA_00768 0.45 0.44 0.47 8 1874 9 1 8 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 0.68 0.56 0.83 10 2004 5 0 2 3 8
RFA_00773 0.71 0.56 0.91 10 1942 4 1 0 3 8
RFA_00779 0.68 0.56 0.83 10 1941 2 0 2 0 8
RFA_00781 0.98 0.97 1.00 31 5019 2 0 0 2 1
RFA_00786 0.48 0.44 0.54 14 5024 14 1 11 2 18
RFA_00791 0.89 0.88 0.90 28 5120 6 2 1 3 4
RFA_00792 0.95 0.94 0.97 30 5019 3 0 1 2 2
RFA_00801 0.81 0.78 0.83 25 5020 8 0 5 3 7
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.40 0.38 0.43 6 2131 8 0 8 0 10
SPR_00020 0.82 0.80 0.84 16 2682 6 0 3 3 4
SPR_00137 0.84 0.86 0.82 18 2904 10 0 4 6 3
SPR_00273 0.52 0.57 0.48 12 2825 13 2 11 0 9
SPR_00394 0.56 0.52 0.61 11 3637 11 5 2 4 10
SPR_00402 0.60 0.48 0.77 10 2543 3 0 3 0 11
SPR_00721 1.00 1.00 1.00 21 2905 2 0 0 2 0
SPR_00816 0.31 0.35 0.28 7 3461 21 5 13 3 13
SRP_00020 0.77 0.79 0.76 26 5531 8 1 7 0 7
SRP_00058 0.87 0.88 0.86 30 5743 9 1 4 4 4
SRP_00084 0.78 0.79 0.77 27 5425 8 1 7 0 7
SRP_00105 0.15 0.15 0.16 5 5534 26 2 24 0 29
SRP_00134 0.64 0.69 0.59 20 5961 19 3 11 5 9
SRP_00137 0.74 0.84 0.66 21 4154 13 4 7 2 4
SRP_00141 0.73 0.71 0.76 29 6290 10 1 8 1 12
SRP_00146 0.82 0.83 0.81 30 5216 8 1 6 1 6
SRP_00200 0.79 0.81 0.78 29 6866 10 1 7 2 7
SRP_00231 0.90 0.91 0.89 31 5425 4 1 3 0 3
SRP_00273 0.84 0.85 0.83 34 6745 10 1 6 3 6
SRP_00274 0.93 0.95 0.92 36 6864 5 1 2 2 2
SRP_00285 0.97 0.97 0.97 29 3711 1 0 1 0 1
SRP_00338 0.97 0.97 0.97 35 5424 2 0 1 1 1
SRP_00341 0.47 0.48 0.45 15 4720 19 0 18 1 16
SRP_00357 0.96 0.97 0.95 35 5319 3 1 1 1 1
SRP_00367 0.96 0.97 0.94 34 6750 3 1 1 1 1

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 512
Total TN 437968
Total FP 145
Total FP CONTRA 14
Total FP INCONS 53
Total FP COMP 78
Total FN 2103
Total Scores
MCC 0.415
Average MCC ± 95% Confidence Intervals 0.323 ± 0.066
Sensitivity 0.196
Positive Predictive Value 0.884
Nr of predictions 123

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01484 0.00 0.00 0.00 0 7503 0 0 0 0 39
CRW_01499 0.00 0.00 0.00 0 8001 0 0 0 0 41
CRW_01603 0.00 0.00 0.00 0 7140 0 0 0 0 37
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.58 0.34 1.00 14 5036 0 0 0 0 27
PDB_00553 0.79 0.64 1.00 7 458 0 0 0 0 4
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00810 0.64 0.41 1.00 7 1074 0 0 0 0 10
PDB_01001 0.00 0.00 0.00 0 2145 0 0 0 0 18
PDB_01050 0.62 0.38 1.00 5 625 1 0 0 1 8
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.77 0.63 0.94 33 10118 3 1 1 1 19
PDB_01152 0.88 0.79 1.00 11 550 0 0 0 0 3
RFA_00389 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00391 0.93 0.87 1.00 13 1418 2 0 0 2 2
RFA_00409 0.77 0.60 1.00 9 1422 1 0 0 1 6
RFA_00416 0.93 0.93 0.93 14 1470 4 0 1 3 1
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00440 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00449 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.56 0.31 1.00 11 13519 2 0 0 2 24
RFA_00604 0.56 0.31 1.00 11 13519 6 0 0 6 24
RFA_00605 0.41 0.17 1.00 6 15219 2 0 0 2 29
RFA_00607 0.25 0.08 0.75 3 17762 10 0 1 9 33
RFA_00609 0.27 0.14 0.56 5 17946 10 2 2 6 32
RFA_00610 0.37 0.14 1.00 5 17200 5 0 0 5 32
RFA_00611 0.38 0.14 1.00 5 13036 0 0 0 0 30
RFA_00613 0.24 0.14 0.42 5 12868 7 4 3 0 30
RFA_00615 0.48 0.23 1.00 8 13358 1 0 0 1 27
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00642 0.00 0.00 0.00 0 2926 0 0 0 0 18
RFA_00643 0.00 0.00 0.00 0 2211 0 0 0 0 18
RFA_00644 0.00 0.00 0.00 0 2701 0 0 0 0 18
RFA_00645 0.00 0.00 0.00 0 2415 0 0 0 0 18
RFA_00649 0.00 0.00 0.00 0 2145 0 0 0 0 18
RFA_00651 0.00 0.00 0.00 0 2080 0 0 0 0 18
RFA_00653 0.00 0.00 0.00 0 2145 0 0 0 0 18
RFA_00654 0.00 0.00 0.00 0 2415 0 0 0 0 18
RFA_00658 0.40 0.29 0.57 4 1121 5 0 3 2 10
RFA_00659 -0.01 0.00 0.00 0 1124 4 0 4 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 -0.01 0.00 0.00 0 985 5 1 4 0 14
RFA_00668 0.50 0.43 0.60 6 980 4 0 4 0 8
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.47 0.36 0.63 5 1120 4 0 3 1 9
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.53 0.43 0.67 6 981 4 0 3 1 8
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.84 0.71 1.00 10 1118 2 0 0 2 4
RFA_00684 0.84 0.71 1.00 10 980 1 0 0 1 4
RFA_00685 0.59 0.36 1.00 5 985 0 0 0 0 9
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.84 0.71 1.00 10 1025 0 0 0 0 4
RFA_00706 0.53 0.29 1.00 4 1031 0 0 0 0 10
RFA_00707 0.53 0.29 1.00 4 1031 0 0 0 0 10
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 -0.01 0.00 0.00 0 984 7 0 6 1 14
RFA_00710 -0.01 0.00 0.00 0 987 3 0 3 0 14
RFA_00711 -0.01 0.00 0.00 0 1031 4 0 4 0 14
RFA_00715 -0.01 0.00 0.00 0 943 3 1 2 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00731 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00733 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00734 0.64 0.42 1.00 5 898 0 0 0 0 7
RFA_00736 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00737 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00745 0.64 0.42 1.00 5 941 1 0 0 1 7
RFA_00749 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00758 0.00 0.00 0.00 0 903 0 0 0 0 12
RFA_00762 0.64 0.42 1.00 5 898 0 0 0 0 7
RFA_00763 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00764 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00765 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00767 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00770 0.62 0.39 1.00 7 2009 0 0 0 0 11
RFA_00773 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00779 0.74 0.56 1.00 10 1943 0 0 0 0 8
RFA_00781 0.25 0.13 0.50 4 5042 4 1 3 0 28
RFA_00786 0.25 0.13 0.50 4 5042 4 1 3 0 28
RFA_00791 0.00 0.00 0.00 0 5151 0 0 0 0 32
RFA_00792 0.00 0.00 0.00 0 5046 4 1 3 0 32
RFA_00801 0.00 0.00 0.00 0 5050 0 0 0 0 32
RFA_00808 0.00 0.00 0.00 0 2016 0 0 0 0 16
RFA_00809 0.00 0.00 0.00 0 2145 0 0 0 0 16
SPR_00020 0.00 0.00 0.00 0 2701 0 0 0 0 20
SPR_00137 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00273 0.00 0.00 0.00 0 2850 0 0 0 0 21
SPR_00394 0.00 0.00 0.00 0 3655 0 0 0 0 21
SPR_00402 0.00 0.00 0.00 0 2556 0 0 0 0 21
SPR_00721 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00816 0.00 0.00 0.00 0 3486 0 0 0 0 20
SRP_00020 0.00 0.00 0.00 0 5565 0 0 0 0 33
SRP_00058 0.00 0.00 0.00 0 5778 0 0 0 0 34
SRP_00084 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00105 0.00 0.00 0.00 0 5565 0 0 0 0 34
SRP_00134 0.00 0.00 0.00 0 5995 0 0 0 0 29
SRP_00137 0.00 0.00 0.00 0 4186 0 0 0 0 25
SRP_00141 0.00 0.00 0.00 0 6328 0 0 0 0 41
SRP_00146 0.00 0.00 0.00 0 5253 0 0 0 0 36
SRP_00200 0.00 0.00 0.00 0 6903 0 0 0 0 36
SRP_00231 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00273 0.00 0.00 0.00 0 6786 0 0 0 0 40
SRP_00274 0.00 0.00 0.00 0 6903 0 0 0 0 38
SRP_00285 0.00 0.00 0.00 0 3741 0 0 0 0 30
SRP_00338 0.00 0.00 0.00 0 5460 0 0 0 0 36
SRP_00341 0.00 0.00 0.00 0 4753 0 0 0 0 31
SRP_00357 0.00 0.00 0.00 0 5356 0 0 0 0 36
SRP_00367 0.00 0.00 0.00 0 6786 0 0 0 0 35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.