CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric Contrafold Murlet(seed)
MCC 0.633 > 0.468
Average MCC ± 95% Confidence Intervals 0.582 ± 0.069 > 0.340 ± 0.080
Sensitivity 0.589 > 0.266
Positive Predictive Value 0.684 < 0.828
Total TP 1052 > 475
Total TN 306769 < 307733
Total FP 703 > 103
Total FP CONTRA 64 > 0
Total FP INCONS 422 > 99
Total FP COMP 217 > 4
Total FN 734 < 1311
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Murlet(seed)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1052
Total TN 306769
Total FP 703
Total FP CONTRA 64
Total FP INCONS 422
Total FP COMP 217
Total FN 734
Total Scores
MCC 0.633
Average MCC ± 95% Confidence Intervals 0.582 ± 0.069
Sensitivity 0.589
Positive Predictive Value 0.684
Nr of predictions 91

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.94 0.88 1.00 36 5014 0 0 0 0 5
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 0.33 0.30 0.37 7 2682 13 0 12 1 16
PDB_00810 0.77 0.71 0.86 12 1067 3 0 2 1 5
PDB_01050 0.96 0.92 1.00 12 618 2 0 0 2 1
PDB_01051 0.88 0.85 0.92 11 891 5 0 1 4 2
PDB_01092 0.70 0.65 0.76 34 10108 14 2 9 3 18
PDB_01152 0.96 0.93 1.00 13 548 0 0 0 0 1
RFA_00390 1.00 1.00 1.00 15 1416 3 0 0 3 0
RFA_00416 1.00 1.00 1.00 15 1470 3 0 0 3 0
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00587 1.00 1.00 1.00 15 4836 10 0 0 10 0
RFA_00603 0.73 0.71 0.76 25 13497 8 4 4 0 10
RFA_00604 0.71 0.74 0.68 26 13492 26 2 10 14 9
RFA_00605 0.35 0.34 0.36 12 15192 35 2 19 14 23
RFA_00607 0.87 0.81 0.94 29 17735 11 0 2 9 7
RFA_00609 0.76 0.78 0.74 29 17916 27 2 8 17 8
RFA_00610 0.90 0.86 0.94 32 17171 20 0 2 18 5
RFA_00611 0.82 0.74 0.90 26 13012 6 0 3 3 9
RFA_00613 0.60 0.51 0.69 18 12854 9 3 5 1 17
RFA_00615 0.63 0.57 0.69 20 13337 9 4 5 0 15
RFA_00632 0.38 0.39 0.37 11 4065 19 0 19 0 17
RFA_00636 0.60 0.64 0.56 18 3973 14 4 10 0 10
RFA_00642 0.00 0.00 0.00 0 2915 11 2 9 0 18
RFA_00643 -0.01 0.00 0.00 0 2202 9 1 8 0 18
RFA_00644 0.00 0.00 0.00 0 2692 9 1 8 0 18
RFA_00645 -0.01 0.00 0.00 0 2402 13 3 10 0 18
RFA_00649 0.26 0.22 0.31 4 2132 9 6 3 0 14
RFA_00651 0.40 0.33 0.50 6 2068 6 1 5 0 12
RFA_00653 -0.01 0.00 0.00 0 2133 12 2 10 0 18
RFA_00654 -0.01 0.00 0.00 0 2400 15 2 13 0 18
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00659 -0.01 0.00 0.00 0 1120 10 1 7 2 14
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 0.29 0.29 0.31 4 977 10 1 8 1 10
RFA_00668 0.53 0.43 0.67 6 981 3 0 3 0 8
RFA_00672 -0.01 0.00 0.00 0 897 6 0 6 0 13
RFA_00673 0.42 0.36 0.50 5 1118 6 0 5 1 9
RFA_00674 0.96 0.93 1.00 13 1115 1 0 0 1 1
RFA_00675 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00677 0.59 0.57 0.62 8 977 7 0 5 2 6
RFA_00678 0.53 0.29 1.00 4 942 0 0 0 0 10
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00685 0.44 0.36 0.56 5 981 4 0 4 0 9
RFA_00695 0.44 0.36 0.56 5 7012 29 1 3 25 9
RFA_00703 0.67 0.64 0.69 9 4265 19 1 3 15 5
RFA_00704 0.32 0.21 0.50 3 984 5 0 3 2 11
RFA_00705 0.74 0.71 0.77 10 1022 4 0 3 1 4
RFA_00706 0.37 0.29 0.50 4 1027 4 0 4 0 10
RFA_00707 -0.01 0.00 0.00 0 1027 8 1 7 0 14
RFA_00708 0.40 0.29 0.57 4 1028 3 0 3 0 10
RFA_00709 -0.01 0.00 0.00 0 981 10 0 9 1 14
RFA_00710 -0.01 0.00 0.00 0 979 11 0 11 0 14
RFA_00711 -0.01 0.00 0.00 0 1026 9 0 9 0 14
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 937 9 0 9 0 14
RFA_00717 0.66 0.64 0.69 9 890 4 0 4 0 5
RFA_00730 0.75 0.75 0.75 9 891 5 0 3 2 3
RFA_00731 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00733 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00734 0.83 0.83 0.83 10 891 5 0 2 3 2
RFA_00736 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00737 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00745 0.66 0.67 0.67 8 934 6 1 3 2 4
RFA_00749 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00758 0.60 0.58 0.64 7 892 5 1 3 1 5
RFA_00762 0.64 0.67 0.62 8 890 6 1 4 1 4
RFA_00763 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00764 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00765 0.83 0.83 0.83 10 891 4 0 2 2 2
RFA_00767 0.74 0.56 1.00 10 1881 2 0 0 2 8
RFA_00768 0.45 0.44 0.47 8 1874 9 1 8 0 10
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 0.68 0.56 0.83 10 2004 5 0 2 3 8
RFA_00773 0.71 0.56 0.91 10 1942 4 1 0 3 8
RFA_00779 0.68 0.56 0.83 10 1941 2 0 2 0 8
RFA_00781 0.98 0.97 1.00 31 5019 2 0 0 2 1
RFA_00786 0.48 0.44 0.54 14 5024 14 1 11 2 18
RFA_00791 0.89 0.88 0.90 28 5120 6 2 1 3 4
RFA_00792 0.95 0.94 0.97 30 5019 3 0 1 2 2
RFA_00801 0.81 0.78 0.83 25 5020 8 0 5 3 7
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.40 0.38 0.43 6 2131 8 0 8 0 10
SRP_00137 0.74 0.84 0.66 21 4154 13 4 7 2 4
SRP_00141 0.73 0.71 0.76 29 6290 10 1 8 1 12
SRP_00146 0.82 0.83 0.81 30 5216 8 1 6 1 6
SRP_00285 0.97 0.97 0.97 29 3711 1 0 1 0 1
SRP_00338 0.97 0.97 0.97 35 5424 2 0 1 1 1

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 475
Total TN 307733
Total FP 103
Total FP CONTRA 0
Total FP INCONS 99
Total FP COMP 4
Total FN 1311
Total Scores
MCC 0.468
Average MCC ± 95% Confidence Intervals 0.340 ± 0.080
Sensitivity 0.266
Positive Predictive Value 0.828
Nr of predictions 91

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00005 0.53 0.29 1.00 4 942 2 0 0 2 10
PDB_00012 0.65 0.43 1.00 3 403 0 0 0 0 4
PDB_00213 0.73 0.59 0.92 24 5024 2 0 2 0 17
PDB_00553 0.45 0.27 0.75 3 461 1 0 1 0 8
PDB_00716 0.23 0.13 0.43 3 2694 4 0 4 0 20
PDB_00810 0.63 0.53 0.75 9 1069 3 0 3 0 8
PDB_01050 0.55 0.31 1.00 4 626 1 0 0 1 9
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.69 0.48 1.00 25 10128 0 0 0 0 27
PDB_01152 0.76 0.64 0.90 9 551 1 0 1 0 5
RFA_00390 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00416 0.00 0.00 0.00 0 1485 0 0 0 0 15
RFA_00433 0.00 0.00 0.00 0 1431 0 0 0 0 15
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00604 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00605 0.00 0.00 0.00 0 15225 0 0 0 0 35
RFA_00607 0.00 0.00 0.00 0 17766 0 0 0 0 36
RFA_00609 0.00 0.00 0.00 0 17955 0 0 0 0 37
RFA_00610 0.00 0.00 0.00 0 17205 0 0 0 0 37
RFA_00611 0.00 0.00 0.00 0 13041 0 0 0 0 35
RFA_00613 0.00 0.00 0.00 0 12880 0 0 0 0 35
RFA_00615 0.00 0.00 0.00 0 13366 0 0 0 0 35
RFA_00632 0.21 0.11 0.43 3 4088 4 0 4 0 25
RFA_00636 0.21 0.11 0.43 3 3998 4 0 4 0 25
RFA_00642 0.57 0.44 0.73 8 2915 3 0 3 0 10
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.42 0.33 0.55 6 2690 5 0 5 0 12
RFA_00645 0.00 0.00 0.00 0 2407 8 0 8 0 18
RFA_00649 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00651 0.42 0.33 0.55 6 2069 5 0 5 0 12
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.57 0.44 0.73 8 2404 3 0 3 0 10
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00659 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00668 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00684 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00685 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00706 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00707 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00710 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00711 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00715 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00731 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00733 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00734 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00736 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00737 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00745 1.00 1.00 1.00 12 934 0 0 0 0 0
RFA_00749 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00758 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00762 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00767 0.47 0.33 0.67 6 1882 3 0 3 0 12
RFA_00768 0.41 0.28 0.63 5 1883 3 0 3 0 13
RFA_00769 0.57 0.44 0.73 8 1942 3 0 3 0 10
RFA_00770 0.57 0.44 0.73 8 2005 3 0 3 0 10
RFA_00773 0.41 0.28 0.63 5 1945 3 0 3 0 13
RFA_00779 0.47 0.33 0.67 6 1944 3 0 3 0 12
RFA_00781 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00786 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00791 0.83 0.75 0.92 24 5125 2 0 2 0 8
RFA_00792 0.83 0.75 0.92 24 5024 2 0 2 0 8
RFA_00801 0.80 0.72 0.88 23 5024 3 0 3 0 9
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.50 0.38 0.67 6 2136 3 0 3 0 10
SRP_00137 0.49 0.24 1.00 6 4180 0 0 0 0 19
SRP_00141 0.35 0.12 1.00 5 6323 1 0 0 1 36
SRP_00146 0.41 0.17 1.00 6 5247 0 0 0 0 30
SRP_00285 0.45 0.20 1.00 6 3735 0 0 0 0 24
SRP_00338 0.41 0.17 1.00 6 5454 0 0 0 0 30

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.