CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of HotKnots - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for HotKnots & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric HotKnots Carnac(seed)
MCC 0.619 > 0.420
Average MCC ± 95% Confidence Intervals 0.589 ± 0.059 > 0.324 ± 0.068
Sensitivity 0.615 > 0.199
Positive Predictive Value 0.628 < 0.889
Total TP 1540 > 499
Total TN 383170 < 385060
Total FP 1101 > 120
Total FP CONTRA 138 > 12
Total FP INCONS 773 > 50
Total FP COMP 190 > 58
Total FN 965 < 2006
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of HotKnots and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for HotKnots and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for HotKnots and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for HotKnots and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for HotKnots and Carnac(seed)).

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Performance of HotKnots - scored higher in this pairwise comparison

1. Total counts & total scores for HotKnots

Total Base Pair Counts
Total TP 1540
Total TN 383170
Total FP 1101
Total FP CONTRA 138
Total FP INCONS 773
Total FP COMP 190
Total FN 965
Total Scores
MCC 0.619
Average MCC ± 95% Confidence Intervals 0.589 ± 0.059
Sensitivity 0.615
Positive Predictive Value 0.628
Nr of predictions 120

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2. Individual counts for HotKnots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01484 0.18 0.18 0.18 7 7465 32 4 27 1 32
CRW_01499 0.25 0.24 0.26 10 7963 29 1 27 1 31
CRW_01603 0.83 0.78 0.88 29 7107 7 0 4 3 8
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.92 0.85 1.00 35 5015 0 0 0 0 6
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 -0.01 0.00 0.00 0 2678 24 1 22 1 23
PDB_00810 0.71 0.65 0.79 11 1067 4 0 3 1 6
PDB_01001 0.52 0.56 0.50 10 2125 10 3 7 0 8
PDB_01050 0.96 0.92 1.00 12 618 2 0 0 2 1
PDB_01051 0.75 0.69 0.82 9 892 6 0 2 4 4
PDB_01092 0.69 0.65 0.74 34 10107 13 0 12 1 18
PDB_01152 0.92 0.86 1.00 12 549 0 0 0 0 2
RFA_00389 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00391 0.93 0.87 1.00 13 1418 2 0 0 2 2
RFA_00409 0.55 0.53 0.57 8 1417 7 1 5 1 7
RFA_00416 0.93 0.93 0.93 14 1470 4 0 1 3 1
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00440 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00449 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00587 1.00 1.00 1.00 15 4836 12 0 0 12 0
RFA_00603 0.64 0.69 0.60 24 13490 19 4 12 3 11
RFA_00604 0.72 0.74 0.70 26 13493 22 2 9 11 9
RFA_00605 0.37 0.34 0.40 12 15195 27 3 15 9 23
RFA_00611 0.63 0.63 0.63 22 13006 15 3 10 2 13
RFA_00613 0.61 0.60 0.62 21 12846 15 4 9 2 14
RFA_00615 0.51 0.51 0.51 18 13331 17 8 9 0 17
RFA_00632 0.38 0.39 0.37 11 4065 19 2 17 0 17
RFA_00636 0.42 0.43 0.43 12 3977 16 2 14 0 16
RFA_00642 0.16 0.17 0.17 3 2908 15 1 14 0 15
RFA_00643 0.20 0.22 0.20 4 2191 16 1 15 0 14
RFA_00644 -0.01 0.00 0.00 0 2676 25 6 19 0 18
RFA_00645 -0.01 0.00 0.00 0 2394 21 4 17 0 18
RFA_00649 0.34 0.33 0.35 6 2128 13 2 9 2 12
RFA_00651 0.35 0.33 0.38 6 2064 10 1 9 0 12
RFA_00653 0.34 0.33 0.35 6 2128 11 3 8 0 12
RFA_00654 0.27 0.28 0.28 5 2397 13 2 11 0 13
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00659 -0.01 0.00 0.00 0 1120 10 1 7 2 14
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 0.30 0.29 0.33 4 978 8 1 7 0 10
RFA_00668 0.41 0.43 0.40 6 975 9 0 9 0 8
RFA_00672 -0.01 0.00 0.00 0 895 9 0 8 1 13
RFA_00673 0.42 0.36 0.50 5 1118 6 0 5 1 9
RFA_00674 0.71 0.71 0.71 10 1114 5 0 4 1 4
RFA_00675 0.29 0.29 0.31 4 977 9 1 8 0 10
RFA_00677 0.42 0.43 0.43 6 976 9 0 8 1 8
RFA_00678 0.43 0.29 0.67 4 940 2 0 2 0 10
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00685 0.42 0.36 0.50 5 980 6 0 5 1 9
RFA_00695 0.56 0.50 0.64 7 7010 29 1 3 25 7
RFA_00703 0.67 0.64 0.69 9 4265 18 1 3 14 5
RFA_00704 -0.01 0.00 0.00 0 976 14 2 12 0 14
RFA_00705 0.69 0.71 0.67 10 1020 5 0 5 0 4
RFA_00706 0.29 0.29 0.31 4 1022 10 0 9 1 10
RFA_00707 -0.01 0.00 0.00 0 1026 9 3 6 0 14
RFA_00708 0.30 0.29 0.33 4 1023 10 0 8 2 10
RFA_00709 -0.01 0.00 0.00 0 981 10 0 9 1 14
RFA_00710 -0.01 0.00 0.00 0 981 9 0 9 0 14
RFA_00711 -0.01 0.00 0.00 0 1026 10 0 9 1 14
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 935 11 0 11 0 14
RFA_00717 0.64 0.64 0.64 9 889 5 0 5 0 5
RFA_00730 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00731 0.66 0.67 0.67 8 891 5 1 3 1 4
RFA_00733 0.66 0.67 0.67 8 891 5 1 3 1 4
RFA_00734 0.61 0.67 0.57 8 889 7 1 5 1 4
RFA_00736 0.66 0.67 0.67 8 891 5 1 3 1 4
RFA_00737 0.75 0.75 0.75 9 891 5 0 3 2 3
RFA_00745 0.66 0.67 0.67 8 934 5 1 3 1 4
RFA_00749 0.66 0.67 0.67 8 891 5 1 3 1 4
RFA_00758 0.63 0.58 0.70 7 893 3 1 2 0 5
RFA_00762 0.64 0.67 0.62 8 890 5 1 4 0 4
RFA_00763 0.75 0.75 0.75 9 891 4 0 3 1 3
RFA_00764 0.66 0.67 0.67 8 891 5 1 3 1 4
RFA_00765 0.75 0.75 0.75 9 891 5 0 3 2 3
RFA_00767 0.93 1.00 0.86 18 1870 3 3 0 0 0
RFA_00768 1.00 1.00 1.00 18 1873 0 0 0 0 0
RFA_00769 -0.01 0.00 0.00 0 1934 21 0 19 2 18
RFA_00770 -0.01 0.00 0.00 0 1999 20 0 17 3 18
RFA_00773 -0.01 0.00 0.00 0 1934 22 0 19 3 18
RFA_00779 0.87 0.94 0.81 17 1932 4 3 1 0 1
RFA_00781 0.58 0.59 0.58 19 5017 14 2 12 0 13
RFA_00786 0.71 0.72 0.70 23 5017 10 2 8 0 9
RFA_00791 0.35 0.34 0.35 11 5120 20 5 15 0 21
RFA_00792 0.94 0.94 0.94 30 5018 4 0 2 2 2
RFA_00801 0.85 0.81 0.90 26 5021 4 0 3 1 6
RFA_00808 1.00 1.00 1.00 16 2000 0 0 0 0 0
RFA_00809 0.79 0.81 0.76 13 2128 4 0 4 0 3
SPR_00020 0.76 0.80 0.73 16 2679 8 2 4 2 4
SPR_00137 0.56 0.62 0.52 13 2901 15 4 8 3 8
SPR_00273 0.30 0.33 0.28 7 2825 18 2 16 0 14
SPR_00394 0.30 0.33 0.28 7 3630 20 8 10 2 14
SPR_00402 0.67 0.62 0.72 13 2538 5 0 5 0 8
SPR_00721 0.48 0.52 0.44 11 2901 14 3 11 0 10
SPR_00816 0.31 0.35 0.28 7 3461 21 5 13 3 13
SRP_00020 0.86 0.88 0.85 29 5531 5 1 4 0 4
SRP_00058 0.90 0.91 0.89 31 5743 8 1 3 4 3
SRP_00084 0.87 0.88 0.86 30 5425 5 1 4 0 4
SRP_00105 0.38 0.38 0.39 13 5532 20 3 17 0 21
SRP_00134 0.51 0.55 0.48 16 5962 23 3 14 6 13
SRP_00137 0.74 0.84 0.66 21 4154 13 4 7 2 4
SRP_00141 0.91 0.90 0.93 37 6288 3 1 2 0 4
SRP_00146 0.93 0.94 0.92 34 5216 3 1 2 0 2
SRP_00200 0.92 0.94 0.89 34 6865 4 1 3 0 2
SRP_00231 0.87 0.88 0.86 30 5425 5 1 4 0 4
SRP_00273 0.91 0.93 0.90 37 6745 6 1 3 2 3
SRP_00274 0.96 0.97 0.95 37 6864 3 1 1 1 1
SRP_00285 0.91 0.87 0.96 26 3714 1 0 1 0 4
SRP_00338 0.94 0.94 0.94 34 5424 2 0 2 0 2
SRP_00341 0.74 0.74 0.74 23 4722 8 0 8 0 8
SRP_00357 0.93 0.92 0.94 33 5321 3 1 1 1 3
SRP_00367 0.96 0.97 0.94 34 6750 2 1 1 0 1

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 499
Total TN 385060
Total FP 120
Total FP CONTRA 12
Total FP INCONS 50
Total FP COMP 58
Total FN 2006
Total Scores
MCC 0.420
Average MCC ± 95% Confidence Intervals 0.324 ± 0.068
Sensitivity 0.199
Positive Predictive Value 0.889
Nr of predictions 120

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01484 0.00 0.00 0.00 0 7503 0 0 0 0 39
CRW_01499 0.00 0.00 0.00 0 8001 0 0 0 0 41
CRW_01603 0.00 0.00 0.00 0 7140 0 0 0 0 37
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.58 0.34 1.00 14 5036 0 0 0 0 27
PDB_00553 0.79 0.64 1.00 7 458 0 0 0 0 4
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00810 0.64 0.41 1.00 7 1074 0 0 0 0 10
PDB_01001 0.00 0.00 0.00 0 2145 0 0 0 0 18
PDB_01050 0.62 0.38 1.00 5 625 1 0 0 1 8
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.77 0.63 0.94 33 10118 3 1 1 1 19
PDB_01152 0.88 0.79 1.00 11 550 0 0 0 0 3
RFA_00389 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00391 0.93 0.87 1.00 13 1418 2 0 0 2 2
RFA_00409 0.77 0.60 1.00 9 1422 1 0 0 1 6
RFA_00416 0.93 0.93 0.93 14 1470 4 0 1 3 1
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00440 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00449 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.56 0.31 1.00 11 13519 2 0 0 2 24
RFA_00604 0.56 0.31 1.00 11 13519 6 0 0 6 24
RFA_00605 0.41 0.17 1.00 6 15219 2 0 0 2 29
RFA_00611 0.38 0.14 1.00 5 13036 0 0 0 0 30
RFA_00613 0.24 0.14 0.42 5 12868 7 4 3 0 30
RFA_00615 0.48 0.23 1.00 8 13358 1 0 0 1 27
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00642 0.00 0.00 0.00 0 2926 0 0 0 0 18
RFA_00643 0.00 0.00 0.00 0 2211 0 0 0 0 18
RFA_00644 0.00 0.00 0.00 0 2701 0 0 0 0 18
RFA_00645 0.00 0.00 0.00 0 2415 0 0 0 0 18
RFA_00649 0.00 0.00 0.00 0 2145 0 0 0 0 18
RFA_00651 0.00 0.00 0.00 0 2080 0 0 0 0 18
RFA_00653 0.00 0.00 0.00 0 2145 0 0 0 0 18
RFA_00654 0.00 0.00 0.00 0 2415 0 0 0 0 18
RFA_00658 0.40 0.29 0.57 4 1121 5 0 3 2 10
RFA_00659 -0.01 0.00 0.00 0 1124 4 0 4 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 -0.01 0.00 0.00 0 985 5 1 4 0 14
RFA_00668 0.50 0.43 0.60 6 980 4 0 4 0 8
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.47 0.36 0.63 5 1120 4 0 3 1 9
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.53 0.43 0.67 6 981 4 0 3 1 8
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.84 0.71 1.00 10 1118 2 0 0 2 4
RFA_00684 0.84 0.71 1.00 10 980 1 0 0 1 4
RFA_00685 0.59 0.36 1.00 5 985 0 0 0 0 9
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.84 0.71 1.00 10 1025 0 0 0 0 4
RFA_00706 0.53 0.29 1.00 4 1031 0 0 0 0 10
RFA_00707 0.53 0.29 1.00 4 1031 0 0 0 0 10
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 -0.01 0.00 0.00 0 984 7 0 6 1 14
RFA_00710 -0.01 0.00 0.00 0 987 3 0 3 0 14
RFA_00711 -0.01 0.00 0.00 0 1031 4 0 4 0 14
RFA_00715 -0.01 0.00 0.00 0 943 3 1 2 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00731 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00733 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00734 0.64 0.42 1.00 5 898 0 0 0 0 7
RFA_00736 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00737 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00745 0.64 0.42 1.00 5 941 1 0 0 1 7
RFA_00749 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00758 0.00 0.00 0.00 0 903 0 0 0 0 12
RFA_00762 0.64 0.42 1.00 5 898 0 0 0 0 7
RFA_00763 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00764 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00765 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00767 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00770 0.62 0.39 1.00 7 2009 0 0 0 0 11
RFA_00773 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00779 0.74 0.56 1.00 10 1943 0 0 0 0 8
RFA_00781 0.25 0.13 0.50 4 5042 4 1 3 0 28
RFA_00786 0.25 0.13 0.50 4 5042 4 1 3 0 28
RFA_00791 0.00 0.00 0.00 0 5151 0 0 0 0 32
RFA_00792 0.00 0.00 0.00 0 5046 4 1 3 0 32
RFA_00801 0.00 0.00 0.00 0 5050 0 0 0 0 32
RFA_00808 0.00 0.00 0.00 0 2016 0 0 0 0 16
RFA_00809 0.00 0.00 0.00 0 2145 0 0 0 0 16
SPR_00020 0.00 0.00 0.00 0 2701 0 0 0 0 20
SPR_00137 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00273 0.00 0.00 0.00 0 2850 0 0 0 0 21
SPR_00394 0.00 0.00 0.00 0 3655 0 0 0 0 21
SPR_00402 0.00 0.00 0.00 0 2556 0 0 0 0 21
SPR_00721 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00816 0.00 0.00 0.00 0 3486 0 0 0 0 20
SRP_00020 0.00 0.00 0.00 0 5565 0 0 0 0 33
SRP_00058 0.00 0.00 0.00 0 5778 0 0 0 0 34
SRP_00084 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00105 0.00 0.00 0.00 0 5565 0 0 0 0 34
SRP_00134 0.00 0.00 0.00 0 5995 0 0 0 0 29
SRP_00137 0.00 0.00 0.00 0 4186 0 0 0 0 25
SRP_00141 0.00 0.00 0.00 0 6328 0 0 0 0 41
SRP_00146 0.00 0.00 0.00 0 5253 0 0 0 0 36
SRP_00200 0.00 0.00 0.00 0 6903 0 0 0 0 36
SRP_00231 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00273 0.00 0.00 0.00 0 6786 0 0 0 0 40
SRP_00274 0.00 0.00 0.00 0 6903 0 0 0 0 38
SRP_00285 0.00 0.00 0.00 0 3741 0 0 0 0 30
SRP_00338 0.00 0.00 0.00 0 5460 0 0 0 0 36
SRP_00341 0.00 0.00 0.00 0 4753 0 0 0 0 31
SRP_00357 0.00 0.00 0.00 0 5356 0 0 0 0 36
SRP_00367 0.00 0.00 0.00 0 6786 0 0 0 0 35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.