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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Multilign(seed)
MCC 0.749 > 0.334
Average MCC ± 95% Confidence Intervals 0.740 ± 0.488 > 0.190 ± 0.816
Sensitivity 0.698 > 0.186
Positive Predictive Value 0.811 > 0.615
Total TP 30 > 8
Total TN 3566 < 3590
Total FP 11 > 6
Total FP CONTRA 0 < 1
Total FP INCONS 7 > 4
Total FP COMP 4 > 1
Total FN 13 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Multilign(seed)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 30
Total TN 3566
Total FP 11
Total FP CONTRA 0
Total FP INCONS 7
Total FP COMP 4
Total FN 13
Total Scores
MCC 0.749
Average MCC ± 95% Confidence Intervals 0.740 ± 0.488
Sensitivity 0.698
Positive Predictive Value 0.811
Nr of predictions 3

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.97 0.93 1.00 14 1471 1 0 0 1 1
RFA_00658 0.64 0.57 0.73 8 1117 5 0 3 2 6
RFA_00664 0.61 0.57 0.67 8 978 5 0 4 1 6

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 8
Total TN 3590
Total FP 6
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.334
Average MCC ± 95% Confidence Intervals 0.190 ± 0.816
Sensitivity 0.186
Positive Predictive Value 0.615
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.57 0.53 0.62 8 1472 6 1 4 1 7
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.