CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	Mastr(20)		CMfinder(seed)
MCC	0.748	>	0.736
Average MCC ± 95% Confidence Intervals	0.754 ± 0.061	>	0.667 ± 0.095
Sensitivity	0.683	>	0.607
Positive Predictive Value	0.824	<	0.898
Total TP	407	>	362
Total TN	54967	<	55058
Total FP	128	>	57
Total FP CONTRA	8	>	0
Total FP INCONS	79	>	41
Total FP COMP	41	>	16
Total FN	189	<	234
P-value	1.35806673514e-06

^top

Performance plots

Comparison of performance of Mastr(20) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(20) and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Mastr(20) and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(20) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(20) and CMfinder(seed)).

^top

Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP	407
Total TN	54967
Total FP	128
Total FP CONTRA	8
Total FP INCONS	79
Total FP COMP	41
Total FN	189

Total Scores
MCC	0.748
Average MCC ± 95% Confidence Intervals	0.754 ± 0.061
Sensitivity	0.683
Positive Predictive Value	0.824
Nr of predictions	38

^top

2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.65	0.59	0.73	24	5017	9	0	9	0	17
PDB_00553	mir-TAR links to Rfam database...	1.00	1.00	1.00	11	454	0	0	0	0	0
PDB_00810	s2m links to Rfam database...	0.51	0.41	0.64	7	1070	5	0	4	1	10
PDB_01050	UnaL2 links to Rfam database...	0.78	0.62	1.00	8	622	2	0	0	2	5
PDB_01152	HIV_FS2 links to Rfam database...	0.81	0.79	0.85	11	548	2	0	2	0	3
RFA_00658	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	1117	4	0	3	1	6
RFA_00664	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	979	4	0	3	1	6
RFA_00667	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	980	4	0	3	1	7
RFA_00668	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	980	4	0	3	1	7
RFA_00672	Hammerhead_1 links to Rfam database...	0.36	0.31	0.44	4	894	5	0	5	0	9
RFA_00673	Hammerhead_1 links to Rfam database...	0.60	0.43	0.86	6	1121	2	0	1	1	8
RFA_00674	Hammerhead_1 links to Rfam database...	0.75	0.57	1.00	8	1120	0	0	0	0	6
RFA_00675	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	980	4	0	3	1	7
RFA_00677	Hammerhead_1 links to Rfam database...	0.75	0.57	1.00	8	982	0	0	0	0	6
RFA_00678	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	939	4	0	3	1	10
RFA_00680	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	1117	4	0	3	1	6
RFA_00704	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	979	4	0	3	1	6
RFA_00707	Hammerhead_1 links to Rfam database...	0.35	0.29	0.44	4	1026	5	0	5	0	10
RFA_00715	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	936	4	0	3	1	7
RFA_00717	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	891	3	0	3	0	5
RFA_00730	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00731	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00733	s2m links to Rfam database...	0.87	0.83	0.91	10	892	3	0	1	2	2
RFA_00734	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00736	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00737	s2m links to Rfam database...	0.91	0.83	1.00	10	893	1	0	0	1	2
RFA_00745	s2m links to Rfam database...	0.91	0.83	1.00	10	936	2	0	0	2	2
RFA_00749	s2m links to Rfam database...	0.96	0.92	1.00	11	892	2	0	0	2	1
RFA_00758	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00762	s2m links to Rfam database...	0.96	0.92	1.00	11	892	2	0	0	2	1
RFA_00763	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00764	s2m links to Rfam database...	0.91	0.83	1.00	10	893	2	0	0	2	2
RFA_00765	s2m links to Rfam database...	0.96	0.92	1.00	11	892	2	0	0	2	1
RFA_00786	Gammaretro_CES links to Rfam database...	0.92	0.94	0.91	30	5017	3	2	1	0	2
RFA_00791	Gammaretro_CES links to Rfam database...	0.61	0.63	0.61	20	5118	13	2	11	0	12
RFA_00792	Gammaretro_CES links to Rfam database...	0.73	0.75	0.71	24	5016	10	2	8	0	8
RFA_00801	Gammaretro_CES links to Rfam database...	0.89	0.91	0.88	29	5017	4	2	2	0	3

^top

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	362
Total TN	55058
Total FP	57
Total FP CONTRA	0
Total FP INCONS	41
Total FP COMP	16
Total FN	234

Total Scores
MCC	0.736
Average MCC ± 95% Confidence Intervals	0.667 ± 0.095
Sensitivity	0.607
Positive Predictive Value	0.898
Nr of predictions	38

^top

2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	2	0	0	2	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.85	0.73	1.00	30	5020	0	0	0	0	11
PDB_00553	mir-TAR links to Rfam database...	0.00	0.00	0.00	0	465	0	0	0	0	11
PDB_00810	s2m links to Rfam database...	0.76	0.59	1.00	10	1071	0	0	0	0	7
PDB_01050	UnaL2 links to Rfam database...	0.68	0.46	1.00	6	624	1	0	0	1	7
PDB_01152	HIV_FS2 links to Rfam database...	0.92	0.86	1.00	12	549	0	0	0	0	2
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00664	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00667	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00668	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00672	Hammerhead_1 links to Rfam database...	0.41	0.31	0.57	4	896	3	0	3	0	9
RFA_00673	Hammerhead_1 links to Rfam database...	0.23	0.14	0.40	2	1123	4	0	3	1	12
RFA_00674	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00675	Hammerhead_1 links to Rfam database...	0.35	0.21	0.60	3	985	3	0	2	1	11
RFA_00677	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	983	4	0	3	1	10
RFA_00678	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	940	3	0	2	1	10
RFA_00680	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	4	0	3	1	10
RFA_00704	Hammerhead_1 links to Rfam database...	0.32	0.21	0.50	3	984	4	0	3	1	11
RFA_00707	Hammerhead_1 links to Rfam database...	0.43	0.29	0.67	4	1029	3	0	2	1	10
RFA_00715	Hammerhead_1 links to Rfam database...	0.30	0.14	0.67	2	943	2	0	1	1	12
RFA_00717	Hammerhead_1 links to Rfam database...	0.30	0.21	0.43	3	896	4	0	4	0	11
RFA_00730	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00731	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00733	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00734	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00736	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00737	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00745	s2m links to Rfam database...	0.91	0.83	1.00	10	936	0	0	0	0	2
RFA_00749	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00758	s2m links to Rfam database...	0.86	0.75	1.00	9	894	0	0	0	0	3
RFA_00762	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00763	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00764	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00765	s2m links to Rfam database...	0.91	0.83	1.00	10	893	0	0	0	0	2
RFA_00786	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3
RFA_00791	Gammaretro_CES links to Rfam database...	0.92	0.88	0.97	28	5122	1	0	1	0	4
RFA_00792	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00801	Gammaretro_CES links to Rfam database...	0.95	0.91	1.00	29	5021	0	0	0	0	3

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

2. Individual counts for Mastr(20) [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]