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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Mastr(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Mastr(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Mastr(20) Multilign(seed)
MCC 0.775 > 0.334
Average MCC ± 95% Confidence Intervals 0.760 ± 0.516 > 0.190 ± 0.816
Sensitivity 0.721 > 0.186
Positive Predictive Value 0.838 > 0.615
Total TP 31 > 8
Total TN 3566 < 3590
Total FP 10 > 6
Total FP CONTRA 0 < 1
Total FP INCONS 6 > 4
Total FP COMP 4 > 1
Total FN 12 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of Mastr(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(20) and Multilign(seed)).

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Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 31
Total TN 3566
Total FP 10
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 4
Total FN 12
Total Scores
MCC 0.775
Average MCC ± 95% Confidence Intervals 0.760 ± 0.516
Sensitivity 0.721
Positive Predictive Value 0.838
Nr of predictions 3

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00658 0.64 0.57 0.73 8 1117 4 0 3 1 6
RFA_00664 0.64 0.57 0.73 8 979 4 0 3 1 6

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 8
Total TN 3590
Total FP 6
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.334
Average MCC ± 95% Confidence Intervals 0.190 ± 0.816
Sensitivity 0.186
Positive Predictive Value 0.615
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.57 0.53 0.62 8 1472 6 1 4 1 7
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.