CompaRNA - on-line benchmarks of RNA structure prediction methods

FAQ

Metric	Mastr(seed)		Multilign(seed)
MCC	0.503	>	0.485
Average MCC ± 95% Confidence Intervals	0.481 ± 0.154	>	0.399 ± 0.173
Sensitivity	0.372	<	0.386
Positive Predictive Value	0.690	>	0.619
Total TP	80	<	83
Total TN	22755	>	22737
Total FP	39	<	52
Total FP CONTRA	5	<	6
Total FP INCONS	31	<	45
Total FP COMP	3	>	1
Total FN	135	>	132
P-value	4.84476306662e-07

Comparison of performance of Mastr(seed) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(seed) and Multilign(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Mastr(seed) and Multilign(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(seed) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(seed) and Multilign(seed)).

Total Scores
MCC	0.503
Average MCC ± 95% Confidence Intervals	0.481 ± 0.154
Sensitivity	0.372
Positive Predictive Value	0.690
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00416	Hammerhead_3 links to Rfam database...	0.00	0.00	0.00	0	1485	0	0	0	0	15
RFA_00654	Vimentin3 links to Rfam database...	0.62	0.39	1.00	7	2408	0	0	0	0	11
RFA_00658	Hammerhead_1 links to Rfam database...	0.56	0.43	0.75	6	1120	3	0	2	1	8
RFA_00664	Hammerhead_1 links to Rfam database...	0.27	0.07	1.00	1	989	0	0	0	0	13
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.21	0.75	3	1031	1	0	1	0	11
RFA_00767	Corona_pk3 links to Rfam database...	0.67	0.50	0.90	9	1881	1	0	1	0	9
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.64	0.50	0.82	9	1942	2	1	1	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	0	2	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.64	0.50	0.82	9	1942	2	1	1	0	9
RFA_00779	Corona_pk3 links to Rfam database...	0.65	0.56	0.77	10	1940	3	0	3	0	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	17	2	13	2	16
RFA_00809	RydC links to Rfam database...	0.40	0.38	0.43	6	2131	8	1	7	0	10

Total Scores
MCC	0.485
Average MCC ± 95% Confidence Intervals	0.399 ± 0.173
Sensitivity	0.386
Positive Predictive Value	0.619
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00416	Hammerhead_3 links to Rfam database...	0.57	0.53	0.62	8	1472	6	1	4	1	7
RFA_00654	Vimentin3 links to Rfam database...	0.00	0.00	0.00	0	2414	1	0	1	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1128	0	0	0	0	14
RFA_00664	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1035	0	0	0	0	14
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	4	0	4	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1876	5	0	5	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	0	2	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	1	5	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.61	0.56	0.67	10	1938	5	0	5	0	8
RFA_00808	RydC links to Rfam database...	0.60	0.56	0.64	9	2002	5	0	5	0	7
RFA_00809	RydC links to Rfam database...	0.37	0.38	0.38	6	2129	10	1	9	0	10

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.