CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric McQFold Carnac(seed)
MCC 0.581 > 0.415
Average MCC ± 95% Confidence Intervals 0.564 ± 0.061 > 0.323 ± 0.066
Sensitivity 0.545 > 0.196
Positive Predictive Value 0.624 < 0.884
Total TP 1424 > 512
Total TN 436266 < 437968
Total FP 1051 > 145
Total FP CONTRA 135 > 14
Total FP INCONS 722 > 53
Total FP COMP 194 > 78
Total FN 1191 < 2103
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of McQFold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Carnac(seed)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 1424
Total TN 436266
Total FP 1051
Total FP CONTRA 135
Total FP INCONS 722
Total FP COMP 194
Total FN 1191
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.564 ± 0.061
Sensitivity 0.545
Positive Predictive Value 0.624
Nr of predictions 123

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01484 0.42 0.41 0.44 16 7467 20 2 18 0 23
CRW_01499 0.27 0.24 0.30 10 7968 24 1 22 1 31
CRW_01603 0.22 0.22 0.24 8 7106 26 6 20 0 29
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.72 0.68 0.76 28 5013 9 0 9 0 13
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 0.68 0.70 0.67 16 2677 9 0 8 1 7
PDB_00810 0.51 0.41 0.64 7 1070 4 2 2 0 10
PDB_01001 0.37 0.39 0.37 7 2126 12 3 9 0 11
PDB_01050 0.92 0.85 1.00 11 619 2 0 0 2 2
PDB_01051 0.79 0.69 0.90 9 893 2 0 1 1 4
PDB_01092 0.81 0.75 0.89 39 10109 6 1 4 1 13
PDB_01152 0.88 0.79 1.00 11 550 0 0 0 0 3
RFA_00389 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00391 0.93 0.87 1.00 13 1418 2 0 0 2 2
RFA_00409 0.77 0.60 1.00 9 1422 1 0 0 1 6
RFA_00416 1.00 1.00 1.00 15 1470 4 0 0 4 0
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00440 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 3 0 0 3 1
RFA_00449 0.97 0.93 1.00 14 1471 3 0 0 3 1
RFA_00587 1.00 1.00 1.00 15 4836 8 0 0 8 0
RFA_00603 0.34 0.29 0.42 10 13506 15 4 10 1 25
RFA_00604 0.71 0.66 0.77 23 13500 14 2 5 7 12
RFA_00605 0.36 0.34 0.38 12 15193 31 3 17 11 23
RFA_00607 0.65 0.61 0.69 22 17734 17 3 7 7 14
RFA_00609 0.77 0.76 0.78 28 17919 18 2 6 10 9
RFA_00610 0.56 0.57 0.55 21 17167 25 2 15 8 16
RFA_00611 0.58 0.54 0.61 19 13010 12 3 9 0 16
RFA_00613 0.15 0.14 0.16 5 12848 27 6 21 0 30
RFA_00615 0.32 0.29 0.37 10 13339 18 4 13 1 25
RFA_00632 0.88 0.89 0.86 25 4066 4 3 1 0 3
RFA_00636 0.73 0.71 0.74 20 3978 7 5 2 0 8
RFA_00642 -0.01 0.00 0.00 0 2913 13 1 12 0 18
RFA_00643 -0.01 0.00 0.00 0 2196 15 1 14 0 18
RFA_00644 -0.01 0.00 0.00 0 2684 17 3 14 0 18
RFA_00645 -0.01 0.00 0.00 0 2403 12 3 9 0 18
RFA_00649 0.78 0.67 0.92 12 2132 1 0 1 0 6
RFA_00651 0.40 0.33 0.50 6 2068 6 0 6 0 12
RFA_00653 0.33 0.33 0.33 6 2127 12 3 9 0 12
RFA_00654 -0.01 0.00 0.00 0 2403 12 2 10 0 18
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00659 -0.01 0.00 0.00 0 1125 5 0 3 2 14
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 -0.01 0.00 0.00 0 981 10 1 8 1 14
RFA_00668 0.50 0.43 0.60 6 980 4 0 4 0 8
RFA_00672 -0.01 0.00 0.00 0 895 10 0 8 2 13
RFA_00673 0.47 0.36 0.63 5 1120 4 0 3 1 9
RFA_00674 0.96 0.93 1.00 13 1115 1 0 0 1 1
RFA_00675 0.28 0.29 0.29 4 976 10 1 9 0 10
RFA_00677 0.74 0.71 0.77 10 977 6 0 3 3 4
RFA_00678 0.53 0.29 1.00 4 942 0 0 0 0 10
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.84 0.71 1.00 10 980 1 0 0 1 4
RFA_00685 0.47 0.36 0.63 5 982 4 0 3 1 9
RFA_00695 0.00 0.00 0.00 0 7007 29 4 10 15 14
RFA_00703 0.44 0.43 0.46 6 4265 19 1 6 12 8
RFA_00704 -0.01 0.00 0.00 0 983 8 0 7 1 14
RFA_00705 0.74 0.71 0.77 10 1022 4 0 3 1 4
RFA_00706 -0.01 0.00 0.00 0 1030 5 0 5 0 14
RFA_00707 -0.01 0.00 0.00 0 1030 5 0 5 0 14
RFA_00708 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00709 -0.01 0.00 0.00 0 984 7 0 6 1 14
RFA_00710 -0.01 0.00 0.00 0 980 10 0 10 0 14
RFA_00711 -0.01 0.00 0.00 0 1023 12 0 12 0 14
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00717 0.69 0.64 0.75 9 891 3 0 3 0 5
RFA_00730 0.43 0.42 0.45 5 892 7 1 5 1 7
RFA_00731 0.48 0.42 0.56 5 894 5 1 3 1 7
RFA_00733 0.43 0.42 0.45 5 892 7 1 5 1 7
RFA_00734 0.67 0.58 0.78 7 894 3 0 2 1 5
RFA_00736 0.48 0.42 0.56 5 894 5 1 3 1 7
RFA_00737 0.43 0.42 0.45 5 892 7 0 6 1 7
RFA_00745 0.43 0.42 0.45 5 935 7 1 5 1 7
RFA_00749 0.48 0.42 0.56 5 894 5 1 3 1 7
RFA_00758 0.40 0.33 0.50 4 895 4 2 2 0 8
RFA_00762 0.31 0.33 0.31 4 890 9 2 7 0 8
RFA_00763 0.43 0.42 0.45 5 892 7 1 5 1 7
RFA_00764 0.43 0.42 0.45 5 892 7 1 5 1 7
RFA_00765 0.51 0.42 0.63 5 895 4 0 3 1 7
RFA_00767 1.00 1.00 1.00 18 1873 0 0 0 0 0
RFA_00768 1.00 1.00 1.00 18 1873 0 0 0 0 0
RFA_00769 0.85 0.94 0.77 17 1931 5 4 1 0 1
RFA_00770 0.88 0.78 1.00 14 2002 4 0 0 4 4
RFA_00773 0.97 1.00 0.95 18 1934 5 1 0 4 0
RFA_00779 0.97 0.94 1.00 17 1936 0 0 0 0 1
RFA_00781 0.97 0.94 1.00 30 5020 1 0 0 1 2
RFA_00786 0.21 0.19 0.25 6 5026 19 2 16 1 26
RFA_00791 0.60 0.56 0.64 18 5123 11 0 10 1 14
RFA_00792 0.97 0.94 1.00 30 5020 1 0 0 1 2
RFA_00801 0.69 0.63 0.77 20 5024 8 0 6 2 12
RFA_00808 1.00 1.00 1.00 16 2000 0 0 0 0 0
RFA_00809 0.79 0.81 0.76 13 2128 4 0 4 0 3
SPR_00020 0.92 0.85 1.00 17 2684 2 0 0 2 3
SPR_00137 0.84 0.86 0.82 18 2904 11 0 4 7 3
SPR_00273 0.76 0.76 0.76 16 2829 6 0 5 1 5
SPR_00394 0.87 0.81 0.94 17 3637 8 0 1 7 4
SPR_00402 1.00 1.00 1.00 21 2535 2 0 0 2 0
SPR_00721 1.00 1.00 1.00 21 2905 2 0 0 2 0
SPR_00816 0.31 0.35 0.28 7 3461 21 5 13 3 13
SRP_00020 0.73 0.73 0.73 24 5532 10 1 8 1 9
SRP_00058 0.38 0.38 0.38 13 5744 23 4 17 2 21
SRP_00084 0.65 0.56 0.76 19 5435 6 2 4 0 15
SRP_00105 0.30 0.29 0.32 10 5534 21 0 21 0 24
SRP_00134 0.16 0.17 0.16 5 5964 29 6 20 3 24
SRP_00137 0.37 0.40 0.36 10 4158 18 7 11 0 15
SRP_00141 0.84 0.80 0.87 33 6290 5 1 4 0 8
SRP_00146 0.37 0.33 0.41 12 5224 17 2 15 0 24
SRP_00200 0.87 0.78 0.97 28 6874 1 0 1 0 8
SRP_00231 0.62 0.59 0.67 20 5430 10 2 8 0 14
SRP_00273 0.89 0.88 0.90 35 6747 5 2 2 1 5
SRP_00274 0.83 0.79 0.88 30 6869 4 1 3 0 8
SRP_00285 0.38 0.37 0.41 11 3714 16 1 15 0 19
SRP_00338 0.75 0.75 0.75 27 5424 9 3 6 0 9
SRP_00341 -0.01 0.00 0.00 0 4731 22 4 18 0 31
SRP_00357 0.46 0.47 0.46 17 5319 20 3 17 0 19
SRP_00367 0.45 0.43 0.47 15 6754 17 0 17 0 20

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 512
Total TN 437968
Total FP 145
Total FP CONTRA 14
Total FP INCONS 53
Total FP COMP 78
Total FN 2103
Total Scores
MCC 0.415
Average MCC ± 95% Confidence Intervals 0.323 ± 0.066
Sensitivity 0.196
Positive Predictive Value 0.884
Nr of predictions 123

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01484 0.00 0.00 0.00 0 7503 0 0 0 0 39
CRW_01499 0.00 0.00 0.00 0 8001 0 0 0 0 41
CRW_01603 0.00 0.00 0.00 0 7140 0 0 0 0 37
PDB_00005 0.88 0.79 1.00 11 935 0 0 0 0 3
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.58 0.34 1.00 14 5036 0 0 0 0 27
PDB_00553 0.79 0.64 1.00 7 458 0 0 0 0 4
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00810 0.64 0.41 1.00 7 1074 0 0 0 0 10
PDB_01001 0.00 0.00 0.00 0 2145 0 0 0 0 18
PDB_01050 0.62 0.38 1.00 5 625 1 0 0 1 8
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.77 0.63 0.94 33 10118 3 1 1 1 19
PDB_01152 0.88 0.79 1.00 11 550 0 0 0 0 3
RFA_00389 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00390 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00391 0.93 0.87 1.00 13 1418 2 0 0 2 2
RFA_00409 0.77 0.60 1.00 9 1422 1 0 0 1 6
RFA_00416 0.93 0.93 0.93 14 1470 4 0 1 3 1
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00440 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00449 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00587 0.00 0.00 0.00 0 4851 0 0 0 0 15
RFA_00603 0.56 0.31 1.00 11 13519 2 0 0 2 24
RFA_00604 0.56 0.31 1.00 11 13519 6 0 0 6 24
RFA_00605 0.41 0.17 1.00 6 15219 2 0 0 2 29
RFA_00607 0.25 0.08 0.75 3 17762 10 0 1 9 33
RFA_00609 0.27 0.14 0.56 5 17946 10 2 2 6 32
RFA_00610 0.37 0.14 1.00 5 17200 5 0 0 5 32
RFA_00611 0.38 0.14 1.00 5 13036 0 0 0 0 30
RFA_00613 0.24 0.14 0.42 5 12868 7 4 3 0 30
RFA_00615 0.48 0.23 1.00 8 13358 1 0 0 1 27
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00642 0.00 0.00 0.00 0 2926 0 0 0 0 18
RFA_00643 0.00 0.00 0.00 0 2211 0 0 0 0 18
RFA_00644 0.00 0.00 0.00 0 2701 0 0 0 0 18
RFA_00645 0.00 0.00 0.00 0 2415 0 0 0 0 18
RFA_00649 0.00 0.00 0.00 0 2145 0 0 0 0 18
RFA_00651 0.00 0.00 0.00 0 2080 0 0 0 0 18
RFA_00653 0.00 0.00 0.00 0 2145 0 0 0 0 18
RFA_00654 0.00 0.00 0.00 0 2415 0 0 0 0 18
RFA_00658 0.40 0.29 0.57 4 1121 5 0 3 2 10
RFA_00659 -0.01 0.00 0.00 0 1124 4 0 4 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00667 -0.01 0.00 0.00 0 985 5 1 4 0 14
RFA_00668 0.50 0.43 0.60 6 980 4 0 4 0 8
RFA_00672 0.00 0.00 0.00 0 903 0 0 0 0 13
RFA_00673 0.47 0.36 0.63 5 1120 4 0 3 1 9
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.53 0.43 0.67 6 981 4 0 3 1 8
RFA_00678 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00680 0.84 0.71 1.00 10 1118 2 0 0 2 4
RFA_00684 0.84 0.71 1.00 10 980 1 0 0 1 4
RFA_00685 0.59 0.36 1.00 5 985 0 0 0 0 9
RFA_00695 0.00 0.00 0.00 0 7021 0 0 0 0 14
RFA_00703 0.00 0.00 0.00 0 4278 0 0 0 0 14
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.84 0.71 1.00 10 1025 0 0 0 0 4
RFA_00706 0.53 0.29 1.00 4 1031 0 0 0 0 10
RFA_00707 0.53 0.29 1.00 4 1031 0 0 0 0 10
RFA_00708 0.00 0.00 0.00 0 1035 0 0 0 0 14
RFA_00709 -0.01 0.00 0.00 0 984 7 0 6 1 14
RFA_00710 -0.01 0.00 0.00 0 987 3 0 3 0 14
RFA_00711 -0.01 0.00 0.00 0 1031 4 0 4 0 14
RFA_00715 -0.01 0.00 0.00 0 943 3 1 2 0 14
RFA_00716 0.00 0.00 0.00 0 946 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00731 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00733 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00734 0.64 0.42 1.00 5 898 0 0 0 0 7
RFA_00736 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00737 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00745 0.64 0.42 1.00 5 941 1 0 0 1 7
RFA_00749 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00758 0.00 0.00 0.00 0 903 0 0 0 0 12
RFA_00762 0.64 0.42 1.00 5 898 0 0 0 0 7
RFA_00763 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00764 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00765 0.64 0.42 1.00 5 898 1 0 0 1 7
RFA_00767 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00768 0.74 0.56 1.00 10 1881 0 0 0 0 8
RFA_00769 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00770 0.62 0.39 1.00 7 2009 0 0 0 0 11
RFA_00773 0.71 0.56 0.91 10 1942 1 1 0 0 8
RFA_00779 0.74 0.56 1.00 10 1943 0 0 0 0 8
RFA_00781 0.25 0.13 0.50 4 5042 4 1 3 0 28
RFA_00786 0.25 0.13 0.50 4 5042 4 1 3 0 28
RFA_00791 0.00 0.00 0.00 0 5151 0 0 0 0 32
RFA_00792 0.00 0.00 0.00 0 5046 4 1 3 0 32
RFA_00801 0.00 0.00 0.00 0 5050 0 0 0 0 32
RFA_00808 0.00 0.00 0.00 0 2016 0 0 0 0 16
RFA_00809 0.00 0.00 0.00 0 2145 0 0 0 0 16
SPR_00020 0.00 0.00 0.00 0 2701 0 0 0 0 20
SPR_00137 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00273 0.00 0.00 0.00 0 2850 0 0 0 0 21
SPR_00394 0.00 0.00 0.00 0 3655 0 0 0 0 21
SPR_00402 0.00 0.00 0.00 0 2556 0 0 0 0 21
SPR_00721 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00816 0.00 0.00 0.00 0 3486 0 0 0 0 20
SRP_00020 0.00 0.00 0.00 0 5565 0 0 0 0 33
SRP_00058 0.00 0.00 0.00 0 5778 0 0 0 0 34
SRP_00084 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00105 0.00 0.00 0.00 0 5565 0 0 0 0 34
SRP_00134 0.00 0.00 0.00 0 5995 0 0 0 0 29
SRP_00137 0.00 0.00 0.00 0 4186 0 0 0 0 25
SRP_00141 0.00 0.00 0.00 0 6328 0 0 0 0 41
SRP_00146 0.00 0.00 0.00 0 5253 0 0 0 0 36
SRP_00200 0.00 0.00 0.00 0 6903 0 0 0 0 36
SRP_00231 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00273 0.00 0.00 0.00 0 6786 0 0 0 0 40
SRP_00274 0.00 0.00 0.00 0 6903 0 0 0 0 38
SRP_00285 0.00 0.00 0.00 0 3741 0 0 0 0 30
SRP_00338 0.00 0.00 0.00 0 5460 0 0 0 0 36
SRP_00341 0.00 0.00 0.00 0 4753 0 0 0 0 31
SRP_00357 0.00 0.00 0.00 0 5356 0 0 0 0 36
SRP_00367 0.00 0.00 0.00 0 6786 0 0 0 0 35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.