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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric Murlet(20) PPfold(seed)
MCC 0.618 > 0.352
Average MCC ± 95% Confidence Intervals 0.614 ± 0.131 > 0.277 ± 0.179
Sensitivity 0.412 > 0.135
Positive Predictive Value 0.932 > 0.927
Total TP 232 > 76
Total TN 80966 < 81133
Total FP 26 > 12
Total FP CONTRA 2 > 0
Total FP INCONS 15 > 6
Total FP COMP 9 > 6
Total FN 331 < 487
P-value 5.1503931209e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and PPfold(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and PPfold(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and PPfold(seed)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 232
Total TN 80966
Total FP 26
Total FP CONTRA 2
Total FP INCONS 15
Total FP COMP 9
Total FN 331
Total Scores
MCC 0.618
Average MCC ± 95% Confidence Intervals 0.614 ± 0.131
Sensitivity 0.412
Positive Predictive Value 0.932
Nr of predictions 22

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00390 0.97 0.93 1.00 14 1417 3 0 0 3 1
RFA_00416 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00749 0.75 0.75 0.75 9 891 4 0 3 1 3
RFA_00764 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00765 0.75 0.75 0.75 9 891 4 0 3 1 3
SPR_00277 0.98 0.95 1.00 20 2906 0 0 0 0 1
SPR_00721 0.88 0.86 0.90 18 2906 2 0 2 0 3
SPR_01157 0.81 0.81 0.81 17 2754 4 0 4 0 4
SRP_00020 0.64 0.48 0.84 16 5546 3 1 2 0 17
SRP_00058 0.45 0.21 1.00 7 5771 0 0 0 0 27
SRP_00084 0.45 0.21 1.00 7 5453 0 0 0 0 27
SRP_00105 0.45 0.21 1.00 7 5558 0 0 0 0 27
SRP_00141 0.38 0.15 1.00 6 6322 0 0 0 0 35
SRP_00231 0.45 0.21 1.00 7 5453 0 0 0 0 27
SRP_00273 0.71 0.55 0.92 22 6762 2 1 1 0 18
SRP_00274 0.43 0.18 1.00 7 6896 0 0 0 0 31
SRP_00338 0.44 0.19 1.00 7 5453 0 0 0 0 29
SRP_00341 0.47 0.23 1.00 7 4746 0 0 0 0 24
SRP_00357 0.55 0.31 1.00 11 5345 0 0 0 0 25

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 76
Total TN 81133
Total FP 12
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 6
Total FN 487
Total Scores
MCC 0.352
Average MCC ± 95% Confidence Intervals 0.277 ± 0.179
Sensitivity 0.135
Positive Predictive Value 0.927
Nr of predictions 22

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00390 1.00 1.00 1.00 15 1416 1 0 0 1 0
RFA_00416 1.00 1.00 1.00 15 1470 1 0 0 1 0
RFA_00433 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00658 0.38 0.14 1.00 2 1126 1 0 0 1 12
RFA_00664 0.38 0.14 1.00 2 988 1 0 0 1 12
RFA_00749 0.78 0.75 0.82 9 892 2 0 2 0 3
RFA_00764 0.78 0.75 0.82 9 892 2 0 2 0 3
RFA_00765 0.78 0.75 0.82 9 892 2 0 2 0 3
SPR_00277 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_00721 0.00 0.00 0.00 0 2926 0 0 0 0 21
SPR_01157 0.00 0.00 0.00 0 2775 0 0 0 0 21
SRP_00020 0.00 0.00 0.00 0 5565 0 0 0 0 33
SRP_00058 0.00 0.00 0.00 0 5778 0 0 0 0 34
SRP_00084 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00105 0.00 0.00 0.00 0 5565 0 0 0 0 34
SRP_00141 0.00 0.00 0.00 0 6328 0 0 0 0 41
SRP_00231 0.00 0.00 0.00 0 5460 0 0 0 0 34
SRP_00273 0.00 0.00 0.00 0 6786 0 0 0 0 40
SRP_00274 0.00 0.00 0.00 0 6903 0 0 0 0 38
SRP_00338 0.00 0.00 0.00 0 5460 0 0 0 0 36
SRP_00341 0.00 0.00 0.00 0 4753 0 0 0 0 31
SRP_00357 0.00 0.00 0.00 0 5356 0 0 0 0 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.