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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric PPfold(20) Multilign(seed)
MCC 0.531 > 0.334
Average MCC ± 95% Confidence Intervals 0.320 ± 1.390 > 0.190 ± 0.816
Sensitivity 0.326 > 0.186
Positive Predictive Value 0.875 > 0.615
Total TP 14 > 8
Total TN 3587 < 3590
Total FP 4 < 6
Total FP CONTRA 0 < 1
Total FP INCONS 2 < 4
Total FP COMP 2 > 1
Total FN 29 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 14
Total TN 3587
Total FP 4
Total FP CONTRA 0
Total FP INCONS 2
Total FP COMP 2
Total FN 29
Total Scores
MCC 0.531
Average MCC ± 95% Confidence Intervals 0.320 ± 1.390
Sensitivity 0.326
Positive Predictive Value 0.875
Nr of predictions 3

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00658 0.00 0.00 0.00 0 1127 1 0 1 0 14
RFA_00664 0.00 0.00 0.00 0 989 1 0 1 0 14

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 8
Total TN 3590
Total FP 6
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.334
Average MCC ± 95% Confidence Intervals 0.190 ± 0.816
Sensitivity 0.186
Positive Predictive Value 0.615
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.57 0.53 0.62 8 1472 6 1 4 1 7
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.