CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RSpredict(seed)
MCC	0.380	>	0.375
Average MCC ± 95% Confidence Intervals	0.300 ± 0.117	<	0.370 ± 0.092
Sensitivity	0.170	<	0.254
Positive Predictive Value	0.852	>	0.563
Total TP	156	<	232
Total TN	127505	>	127276
Total FP	34	<	196
Total FP CONTRA	6	<	33
Total FP INCONS	21	<	147
Total FP COMP	7	<	16
Total FN	759	>	683
P-value	0.00476252034473

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Performance plots

Comparison of performance of PPfold(seed) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RSpredict(seed)).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	156
Total TN	127505
Total FP	34
Total FP CONTRA	6
Total FP INCONS	21
Total FP COMP	7
Total FN	759

Total Scores
MCC	0.380
Average MCC ± 95% Confidence Intervals	0.300 ± 0.117
Sensitivity	0.170
Positive Predictive Value	0.852
Nr of predictions	40

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00277	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3655	0	0	0	0	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2556	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3486	0	0	0	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2775	0	0	0	0	21
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	232
Total TN	127276
Total FP	196
Total FP CONTRA	33
Total FP INCONS	147
Total FP COMP	16
Total FN	683

Total Scores
MCC	0.375
Average MCC ± 95% Confidence Intervals	0.370 ± 0.092
Sensitivity	0.254
Positive Predictive Value	0.563
Nr of predictions	40

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2144	1	0	1	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	0.63	0.40	1.00	6	1425	1	0	0	1	9
RFA_00416	Hammerhead_3 links to Rfam database...	0.63	0.40	1.00	6	1479	1	0	0	1	9
RFA_00433	Hammerhead_3 links to Rfam database...	0.63	0.40	1.00	6	1425	1	0	0	1	9
RFA_00654	Vimentin3 links to Rfam database...	0.35	0.28	0.45	5	2404	6	0	6	0	13
RFA_00658	Hammerhead_1 links to Rfam database...	0.64	0.57	0.73	8	1117	4	0	3	1	6
RFA_00664	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	980	4	0	3	1	7
RFA_00708	Hammerhead_1 links to Rfam database...	0.75	0.57	1.00	8	1027	1	0	0	1	6
RFA_00749	s2m links to Rfam database...	0.91	0.83	1.00	10	893	1	0	0	1	2
RFA_00764	s2m links to Rfam database...	0.91	0.83	1.00	10	893	1	0	0	1	2
RFA_00765	s2m links to Rfam database...	0.91	0.83	1.00	10	893	1	0	0	1	2
RFA_00767	Corona_pk3 links to Rfam database...	0.19	0.17	0.23	3	1878	10	3	7	0	15
RFA_00768	Corona_pk3 links to Rfam database...	0.19	0.17	0.23	3	1878	10	3	7	0	15
RFA_00769	Corona_pk3 links to Rfam database...	0.59	0.56	0.63	10	1937	6	4	2	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.54	0.56	0.53	10	1997	9	6	3	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00779	Corona_pk3 links to Rfam database...	0.50	0.50	0.50	9	1935	9	6	3	0	9
RFA_00808	RydC links to Rfam database...	0.60	0.50	0.73	8	2005	4	0	3	1	8
RFA_00809	RydC links to Rfam database...	0.37	0.31	0.45	5	2134	7	0	6	1	11
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2696	5	0	5	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2924	2	0	2	0	21
SPR_00277	tRNA links to Rfam database...	0.00	0.00	0.00	0	2923	4	0	3	1	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3649	7	0	6	1	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2552	4	0	4	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2923	3	0	3	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3484	2	0	2	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2774	1	0	1	0	21
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.38	0.24	0.62	8	5552	5	0	5	0	25
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.31	0.18	0.55	6	5767	6	0	5	1	28
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.34	0.21	0.58	7	5448	5	1	4	0	27
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.34	0.21	0.58	7	5553	5	1	4	0	27
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.65	0.66	0.66	19	5966	11	0	10	1	10
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.26	0.15	0.46	6	6315	7	0	7	0	35
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.46	0.29	0.71	10	5446	4	0	4	0	24
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6778	8	1	7	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6892	11	1	10	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.33	0.20	0.55	6	3730	5	0	5	0	24
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.51	0.33	0.80	12	5445	4	0	3	1	24
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.35	0.23	0.54	7	4740	6	1	5	0	24
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.46	0.31	0.69	11	5340	5	0	5	0	25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]