CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		NanoFolder
MCC	0.732	>	0.338
Average MCC ± 95% Confidence Intervals	0.702 ± 0.077	>	0.367 ± 0.059
Sensitivity	0.555	>	0.392
Positive Predictive Value	0.968	>	0.300
Total TP	828	>	585
Total TN	232950	>	231852
Total FP	60	<	1431
Total FP CONTRA	2	<	266
Total FP INCONS	25	<	1102
Total FP COMP	33	<	63
Total FN	664	<	907
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and NanoFolder).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	828
Total TN	232950
Total FP	60
Total FP CONTRA	2
Total FP INCONS	25
Total FP COMP	33
Total FN	664

Total Scores
MCC	0.732
Average MCC ± 95% Confidence Intervals	0.702 ± 0.077
Sensitivity	0.555
Positive Predictive Value	0.968
Nr of predictions	57

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_01535	5S_rRNA links to Rfam database...	0.73	0.65	0.83	24	7111	7	0	5	2	13
CRW_01539	5S_rRNA links to Rfam database...	0.84	0.70	1.00	26	7114	2	0	0	2	11
CRW_01563	5S_rRNA links to Rfam database...	0.77	0.62	0.96	23	6879	2	0	1	1	14
CRW_01583	5S_rRNA links to Rfam database...	0.77	0.62	0.96	23	7116	2	0	1	1	14
CRW_01590	5S_rRNA links to Rfam database...	0.59	0.35	1.00	13	7127	1	0	0	1	24
CRW_01593	5S_rRNA links to Rfam database...	0.80	0.65	1.00	24	7116	1	0	0	1	13
CRW_01595	5S_rRNA links to Rfam database...	0.79	0.62	1.00	23	8492	1	0	0	1	14
CRW_01603	5S_rRNA links to Rfam database...	0.75	0.57	1.00	21	7119	1	0	0	1	16
CRW_01617	5S_rRNA links to Rfam database...	0.74	0.65	0.86	24	7112	6	0	4	2	13
CRW_01625	5S_rRNA links to Rfam database...	0.87	0.78	0.97	29	7110	2	0	1	1	8
PDB_00070	tRNA links to Rfam database...	0.93	0.88	1.00	21	2829	0	0	0	0	3
PDB_00571	tRNA links to Rfam database...	0.87	0.80	0.95	20	3300	1	1	0	0	5
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_01236	ykoK links to Rfam database...	0.79	0.67	0.95	36	11590	3	0	2	1	18
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	2	0	0	2	0
RFA_00434	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00664	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00674	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1128	0	0	0	0	14
RFA_00675	Hammerhead_1 links to Rfam database...	0.53	0.29	1.00	4	986	0	0	0	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00717	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	903	0	0	0	0	14
RFA_00730	s2m links to Rfam database...	0.81	0.67	1.00	8	895	1	0	0	1	4
RFA_00763	s2m links to Rfam database...	0.81	0.67	1.00	8	895	1	0	0	1	4
RFA_00765	s2m links to Rfam database...	0.81	0.67	1.00	8	895	1	0	0	1	4
SPR_00066	tRNA links to Rfam database...	1.00	1.00	1.00	21	2829	0	0	0	0	0
SPR_00314	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	2	0	0	2	0
SPR_00333	tRNA links to Rfam database...	0.86	0.86	0.86	18	2754	3	0	3	0	3
SPR_00353	tRNA links to Rfam database...	1.00	1.00	1.00	21	2829	0	0	0	0	0
SPR_00452	tRNA links to Rfam database...	1.00	1.00	1.00	21	2829	0	0	0	0	0
SPR_00456	tRNA links to Rfam database...	1.00	1.00	1.00	21	2829	2	0	0	2	0
SPR_00476	tRNA links to Rfam database...	0.90	0.81	1.00	17	2758	0	0	0	0	4
SPR_00496	tRNA links to Rfam database...	1.00	1.00	1.00	21	2754	0	0	0	0	0
SPR_00497	tRNA links to Rfam database...	0.90	0.81	1.00	17	2758	0	0	0	0	4
SPR_00502	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	0	0	0	0	0
SPR_00509	tRNA links to Rfam database...	1.00	1.00	1.00	20	2906	0	0	0	0	0
SPR_00512	tRNA links to Rfam database...	1.00	1.00	1.00	20	2906	0	0	0	0	0
SPR_00868	tRNA links to Rfam database...	0.95	0.95	0.95	20	2905	2	0	1	1	1
SPR_00957	tRNA links to Rfam database...	1.00	1.00	1.00	21	2982	1	0	0	1	0
SPR_01040	tRNA links to Rfam database...	0.87	0.81	0.94	17	2757	2	0	1	1	4
SRP_00038	Bacteria_small_SRP links to Rfam database...	0.46	0.21	1.00	7	5043	0	0	0	0	26
SRP_00046	Bacteria_small_SRP links to Rfam database...	0.47	0.22	1.00	7	4746	0	0	0	0	25
SRP_00170	Bacteria_small_SRP links to Rfam database...	0.64	0.48	0.86	12	4081	3	1	1	1	13
SRP_00194	Bacteria_small_SRP links to Rfam database...	0.53	0.29	1.00	6	3234	0	0	0	0	15
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.44	0.19	1.00	7	6896	0	0	0	0	29
SRP_00233	Bacteria_small_SRP links to Rfam database...	0.35	0.12	1.00	4	5147	0	0	0	0	29
SRP_00243	Bacteria_small_SRP links to Rfam database...	0.47	0.23	1.00	7	5144	0	0	0	0	24
SRP_00244	Bacteria_small_SRP links to Rfam database...	0.42	0.18	1.00	7	6896	0	0	0	0	32
SRP_00266	Bacteria_small_SRP links to Rfam database...	0.49	0.24	1.00	7	4649	0	0	0	0	22
SRP_00269	Bacteria_small_SRP links to Rfam database...	0.55	0.30	1.00	10	5040	0	0	0	0	23
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.52	0.28	1.00	11	6775	0	0	0	0	29
SRP_00303	Bacteria_small_SRP links to Rfam database...	0.19	0.09	0.38	3	6662	5	0	5	0	29
SRP_00333	Bacteria_small_SRP links to Rfam database...	0.45	0.21	1.00	7	5144	0	0	0	0	27
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.44	0.19	1.00	7	5453	0	0	0	0	29
SRP_00358	Bacteria_small_SRP links to Rfam database...	0.45	0.20	1.00	7	6321	0	0	0	0	28
SRP_00383	Bacteria_small_SRP links to Rfam database...	0.54	0.29	1.00	7	3233	0	0	0	0	17

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	585
Total TN	231852
Total FP	1431
Total FP CONTRA	266
Total FP INCONS	1102
Total FP COMP	63
Total FN	907

Total Scores
MCC	0.338
Average MCC ± 95% Confidence Intervals	0.367 ± 0.059
Sensitivity	0.392
Positive Predictive Value	0.300
Nr of predictions	57

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_01535	5S_rRNA links to Rfam database...	0.20	0.24	0.17	9	7088	43	7	36	0	28
CRW_01539	5S_rRNA links to Rfam database...	0.10	0.11	0.10	4	7099	40	1	36	3	33
CRW_01563	5S_rRNA links to Rfam database...	0.11	0.14	0.11	5	6856	43	5	37	1	32
CRW_01583	5S_rRNA links to Rfam database...	0.36	0.41	0.33	15	7095	31	8	22	1	22
CRW_01590	5S_rRNA links to Rfam database...	-0.01	0.00	0.00	0	7093	50	7	40	3	37
CRW_01593	5S_rRNA links to Rfam database...	0.32	0.38	0.29	14	7091	36	5	30	1	23
CRW_01595	5S_rRNA links to Rfam database...	-0.01	0.00	0.00	0	8459	57	10	46	1	37
CRW_01603	5S_rRNA links to Rfam database...	0.41	0.46	0.38	17	7095	29	6	22	1	20
CRW_01617	5S_rRNA links to Rfam database...	0.20	0.24	0.17	9	7087	45	7	37	1	28
CRW_01625	5S_rRNA links to Rfam database...	0.43	0.49	0.38	18	7093	31	7	22	2	19
PDB_00070	tRNA links to Rfam database...	0.25	0.29	0.23	7	2819	24	4	20	0	17
PDB_00571	tRNA links to Rfam database...	-0.01	0.00	0.00	0	3286	36	6	29	1	25
PDB_00828	Purine links to Rfam database...	0.30	0.33	0.28	9	2453	23	0	23	0	18
PDB_01236	ykoK links to Rfam database...	0.31	0.33	0.30	18	11568	43	3	39	1	36
RFA_00416	Hammerhead_3 links to Rfam database...	0.94	1.00	0.88	15	1468	6	2	0	4	0
RFA_00434	Hammerhead_3 links to Rfam database...	0.84	1.00	0.71	15	1410	8	6	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	0.86	1.00	0.75	15	1411	7	5	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	0.94	1.00	0.88	15	1414	4	2	0	2	0
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	978	13	0	12	1	14
RFA_00674	Hammerhead_1 links to Rfam database...	0.12	0.14	0.13	2	1112	15	0	14	1	12
RFA_00675	Hammerhead_1 links to Rfam database...	0.28	0.29	0.29	4	976	10	1	9	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.62	0.64	0.60	9	975	10	0	6	4	5
RFA_00717	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	889	5	2	3	0	5
RFA_00730	s2m links to Rfam database...	0.38	0.42	0.36	5	889	10	3	6	1	7
RFA_00763	s2m links to Rfam database...	0.38	0.42	0.36	5	889	10	3	6	1	7
RFA_00765	s2m links to Rfam database...	0.39	0.42	0.38	5	890	9	2	6	1	7
SPR_00066	tRNA links to Rfam database...	0.47	0.57	0.39	12	2819	20	4	15	1	9
SPR_00314	tRNA links to Rfam database...	0.47	0.57	0.39	12	2895	21	9	10	2	9
SPR_00333	tRNA links to Rfam database...	0.25	0.33	0.21	7	2741	27	10	17	0	14
SPR_00353	tRNA links to Rfam database...	0.64	0.81	0.52	17	2817	16	8	8	0	4
SPR_00452	tRNA links to Rfam database...	0.27	0.33	0.23	7	2820	24	7	16	1	14
SPR_00456	tRNA links to Rfam database...	0.49	0.57	0.43	12	2822	19	5	11	3	9
SPR_00476	tRNA links to Rfam database...	0.47	0.52	0.42	11	2749	17	4	11	2	10
SPR_00496	tRNA links to Rfam database...	0.47	0.57	0.40	12	2745	22	7	11	4	9
SPR_00497	tRNA links to Rfam database...	0.27	0.33	0.23	7	2745	23	5	18	0	14
SPR_00502	tRNA links to Rfam database...	0.27	0.33	0.23	7	2896	26	2	21	3	14
SPR_00509	tRNA links to Rfam database...	0.23	0.30	0.19	6	2895	25	8	17	0	14
SPR_00512	tRNA links to Rfam database...	0.61	0.75	0.50	15	2896	15	6	9	0	5
SPR_00868	tRNA links to Rfam database...	0.49	0.57	0.43	12	2898	19	5	11	3	9
SPR_00957	tRNA links to Rfam database...	0.63	0.76	0.53	16	2973	15	7	7	1	5
SPR_01040	tRNA links to Rfam database...	0.15	0.19	0.13	4	2744	27	4	23	0	17
SRP_00038	Bacteria_small_SRP links to Rfam database...	0.23	0.27	0.20	9	5005	36	1	35	0	24
SRP_00046	Bacteria_small_SRP links to Rfam database...	0.33	0.38	0.29	12	4712	30	3	26	1	20
SRP_00170	Bacteria_small_SRP links to Rfam database...	0.29	0.36	0.25	9	4059	28	4	23	1	16
SRP_00194	Bacteria_small_SRP links to Rfam database...	0.27	0.33	0.23	7	3209	27	5	19	3	14
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.41	0.47	0.35	17	6855	31	4	27	0	19
SRP_00233	Bacteria_small_SRP links to Rfam database...	0.25	0.30	0.22	10	5106	35	4	31	0	23
SRP_00243	Bacteria_small_SRP links to Rfam database...	0.47	0.55	0.40	17	5109	25	7	18	0	14
SRP_00244	Bacteria_small_SRP links to Rfam database...	0.38	0.44	0.34	17	6853	33	2	31	0	22
SRP_00266	Bacteria_small_SRP links to Rfam database...	0.55	0.66	0.46	19	4615	22	8	14	0	10
SRP_00269	Bacteria_small_SRP links to Rfam database...	0.46	0.52	0.43	17	5010	24	6	17	1	16
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.36	0.40	0.33	16	6737	34	6	27	1	24
SRP_00303	Bacteria_small_SRP links to Rfam database...	0.36	0.41	0.33	13	6630	27	3	24	0	19
SRP_00333	Bacteria_small_SRP links to Rfam database...	0.20	0.24	0.19	8	5108	35	3	32	0	26
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.52	0.56	0.49	20	5419	22	4	17	1	16
SRP_00358	Bacteria_small_SRP links to Rfam database...	0.32	0.37	0.28	13	6282	33	4	29	0	22
SRP_00383	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	3205	35	9	26	0	24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]