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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RSpredict(20) Multilign(seed)
MCC 0.739 > 0.334
Average MCC ± 95% Confidence Intervals 0.732 ± 0.293 > 0.190 ± 0.816
Sensitivity 0.698 > 0.186
Positive Predictive Value 0.789 > 0.615
Total TP 30 > 8
Total TN 3565 < 3590
Total FP 13 > 6
Total FP CONTRA 0 < 1
Total FP INCONS 8 > 4
Total FP COMP 5 > 1
Total FN 13 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and Multilign(seed)).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 30
Total TN 3565
Total FP 13
Total FP CONTRA 0
Total FP INCONS 8
Total FP COMP 5
Total FN 13
Total Scores
MCC 0.739
Average MCC ± 95% Confidence Intervals 0.732 ± 0.293
Sensitivity 0.698
Positive Predictive Value 0.789
Nr of predictions 3

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.87 0.87 0.87 13 1470 5 0 2 3 2
RFA_00658 0.69 0.64 0.75 9 1116 4 0 3 1 5
RFA_00664 0.64 0.57 0.73 8 979 4 0 3 1 6

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 8
Total TN 3590
Total FP 6
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.334
Average MCC ± 95% Confidence Intervals 0.190 ± 0.816
Sensitivity 0.186
Positive Predictive Value 0.615
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.57 0.53 0.62 8 1472 6 1 4 1 7
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.