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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Multilign(seed)
MCC 0.571 > 0.334
Average MCC ± 95% Confidence Intervals 0.525 ± 1.263 > 0.190 ± 0.816
Sensitivity 0.512 > 0.186
Positive Predictive Value 0.647 > 0.615
Total TP 22 > 8
Total TN 3569 < 3590
Total FP 17 > 6
Total FP CONTRA 0 < 1
Total FP INCONS 12 > 4
Total FP COMP 5 > 1
Total FN 21 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Multilign(seed)).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 22
Total TN 3569
Total FP 17
Total FP CONTRA 0
Total FP INCONS 12
Total FP COMP 5
Total FN 21
Total Scores
MCC 0.571
Average MCC ± 95% Confidence Intervals 0.525 ± 1.263
Sensitivity 0.512
Positive Predictive Value 0.647
Nr of predictions 3

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 1.00 1.00 1.00 15 1470 2 0 0 2 0
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00664 -0.01 0.00 0.00 0 981 10 0 9 1 14

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 8
Total TN 3590
Total FP 6
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.334
Average MCC ± 95% Confidence Intervals 0.190 ± 0.816
Sensitivity 0.186
Positive Predictive Value 0.615
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00416 0.57 0.53 0.62 8 1472 6 1 4 1 7
RFA_00658 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.