CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	TurboFold(seed)		Afold
MCC	0.797	>	0.671
Average MCC ± 95% Confidence Intervals	0.768 ± 0.100	>	0.658 ± 0.108
Sensitivity	0.758	>	0.657
Positive Predictive Value	0.841	>	0.689
Total TP	435	>	377
Total TN	80190	>	80160
Total FP	127	<	230
Total FP CONTRA	15	<	23
Total FP INCONS	67	<	147
Total FP COMP	45	<	60
Total FN	139	<	197
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of TurboFold(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and Afold).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP	435
Total TN	80190
Total FP	127
Total FP CONTRA	15
Total FP INCONS	67
Total FP COMP	45
Total FN	139

Total Scores
MCC	0.797
Average MCC ± 95% Confidence Intervals	0.768 ± 0.100
Sensitivity	0.758
Positive Predictive Value	0.841
Nr of predictions	28

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	2	0	0	2	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00587	Y_RNA links to Rfam database...	1.00	1.00	1.00	15	4836	11	0	0	11	0
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	16	2	14	0	16
RFA_00654	Vimentin3 links to Rfam database...	0.44	0.33	0.60	6	2405	5	1	3	1	12
RFA_00658	Hammerhead_1 links to Rfam database...	0.59	0.50	0.70	7	1118	5	0	3	2	7
RFA_00664	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	980	11	0	10	1	14
RFA_00703	Hammerhead_1 links to Rfam database...	0.67	0.64	0.69	9	4265	18	1	3	14	5
RFA_00708	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1028	3	0	3	0	10
RFA_00749	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00764	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.74	0.56	1.00	10	1881	0	0	0	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	8	3	5	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	5	0	2	3	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	2	1	0	1	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.38	0.38	0.40	6	2130	9	1	8	0	10
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.88	0.88	0.88	30	5426	4	1	3	0	4
SRP_00146	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5216	3	1	2	0	2
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.90	0.92	0.89	33	6866	4	1	3	0	3
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.91	0.91	0.91	31	5426	3	1	2	0	3
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.94	0.94	0.94	34	5424	2	0	2	0	2
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5319	3	1	2	0	2
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	33	6750	3	1	2	0	2

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	377
Total TN	80160
Total FP	230
Total FP CONTRA	23
Total FP INCONS	147
Total FP COMP	60
Total FN	197

Total Scores
MCC	0.671
Average MCC ± 95% Confidence Intervals	0.658 ± 0.108
Sensitivity	0.657
Positive Predictive Value	0.689
Nr of predictions	28

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00587	Y_RNA links to Rfam database...	0.87	0.87	0.87	13	4836	14	0	2	12	2
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	17	2	14	1	16
RFA_00654	Vimentin3 links to Rfam database...	0.27	0.28	0.28	5	2397	14	2	11	1	13
RFA_00658	Hammerhead_1 links to Rfam database...	0.69	0.64	0.75	9	1116	5	0	3	2	5
RFA_00664	Hammerhead_1 links to Rfam database...	0.07	0.07	0.09	1	979	11	0	10	1	13
RFA_00703	Hammerhead_1 links to Rfam database...	0.67	0.64	0.69	9	4265	18	1	3	14	5
RFA_00708	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	1027	3	0	3	0	9
RFA_00749	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00764	s2m links to Rfam database...	0.66	0.67	0.67	8	891	5	1	3	1	4
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	1	0	0	1	0
RFA_00767	Corona_pk3 links to Rfam database...	0.63	0.56	0.71	10	1877	5	0	4	1	8
RFA_00768	Corona_pk3 links to Rfam database...	0.48	0.44	0.53	8	1876	8	1	6	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	10	3	5	2	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	12	1	10	1	10
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.81	0.82	0.80	28	5425	7	1	6	0	6
SRP_00146	Bacteria_small_SRP links to Rfam database...	0.93	0.94	0.92	34	5216	3	1	2	0	2
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.44	0.44	0.43	16	6866	21	2	19	0	20
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.46	0.47	0.46	16	5425	19	1	18	0	18
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.92	0.92	0.92	33	5424	4	0	3	1	3
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.93	0.92	0.94	33	5321	3	1	1	1	3
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.83	0.86	0.81	30	6749	7	2	5	0	5

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

2. Individual counts for TurboFold(seed) [ download as .csv ]

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]