CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Afold		CMfinder(seed)
MCC	0.629	>	0.451
Average MCC ± 95% Confidence Intervals	0.617 ± 0.065	>	0.451 ± 0.045
Sensitivity	0.627	>	0.271
Positive Predictive Value	0.633	<	0.753
Total TP	2640	>	1139
Total TN	2379048	<	2381706
Total FP	1934	>	403
Total FP CONTRA	278	>	30
Total FP INCONS	1253	>	344
Total FP COMP	403	>	29
Total FN	1570	<	3071
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Afold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and CMfinder(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	2640
Total TN	2379048
Total FP	1934
Total FP CONTRA	278
Total FP INCONS	1253
Total FP COMP	403
Total FN	1570

Total Scores
MCC	0.629
Average MCC ± 95% Confidence Intervals	0.617 ± 0.065
Sensitivity	0.627
Positive Predictive Value	0.633
Nr of predictions	46

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.22	0.22	0.22	25	103625	113	13	77	23	90
CRW_00016	Intron_gpI links to Rfam database...	0.65	0.62	0.69	74	77313	47	5	29	13	46
CRW_00610	Intron_gpI links to Rfam database...	0.42	0.42	0.43	34	36235	46	6	40	0	47
CRW_00613	Intron_gpI links to Rfam database...	0.46	0.42	0.51	33	34915	41	2	30	9	45
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	141	24	53	64	52
CRW_00633	Intron_gpI links to Rfam database...	0.45	0.44	0.47	47	63445	58	10	44	4	59
CRW_00670	Intron_gpI links to Rfam database...	0.77	0.74	0.81	89	70015	26	0	21	5	31
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.64	0.68	75	62725	41	8	27	6	42
CRW_00672	Intron_gpI links to Rfam database...	0.74	0.73	0.74	81	72281	36	10	18	8	30
CRW_00674	Intron_gpI links to Rfam database...	0.55	0.55	0.55	68	83312	61	8	48	5	56
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	75	17	41	17	51
CRW_00692	Intron_gpI links to Rfam database...	0.57	0.57	0.57	51	68545	54	15	24	15	39
PDB_00827	Intron_gpI links to Rfam database...	0.67	0.59	0.76	48	26965	16	0	15	1	33
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.68	26	21283	26	7	5	14	13
RFA_00620	Telomerase-cil links to Rfam database...	0.64	0.62	0.67	24	21909	26	3	9	14	15
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00627	rne5 links to Rfam database...	0.48	0.47	0.48	41	56868	50	10	34	6	46
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00639	7SK links to Rfam database...	0.49	0.49	0.49	43	54528	61	8	36	17	44
RFA_00814	R2_retro_el links to Rfam database...	0.35	0.37	0.33	15	25155	42	7	23	12	26
RFA_00815	R2_retro_el links to Rfam database...	0.56	0.61	0.51	25	24482	35	8	16	11	16
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	32	0	1	31	2
SRP_00016	Archaea_SRP links to Rfam database...	0.92	0.89	0.94	97	47792	8	0	6	2	12
SRP_00130	Archaea_SRP links to Rfam database...	0.24	0.24	0.24	23	49676	72	10	61	1	74
SRP_00142	Archaea_SRP links to Rfam database...	0.57	0.58	0.57	54	45961	43	5	36	2	39
SRP_00143	Archaea_SRP links to Rfam database...	0.36	0.38	0.35	38	49662	72	8	62	2	63
SRP_00144	Archaea_SRP links to Rfam database...	0.74	0.74	0.74	70	46571	31	1	23	7	24
SRP_00197	Archaea_SRP links to Rfam database...	0.24	0.24	0.25	24	49359	72	7	65	0	77
SRP_00199	Archaea_SRP links to Rfam database...	0.67	0.66	0.68	69	50939	34	2	30	2	36
SRP_00201	Archaea_SRP links to Rfam database...	0.84	0.84	0.84	93	47784	20	5	13	2	18
SRP_00202	Archaea_SRP links to Rfam database...	0.95	0.93	0.96	109	54172	6	0	4	2	8
SRP_00203	Archaea_SRP links to Rfam database...	0.73	0.75	0.72	79	48718	37	3	28	6	26
SRP_00204	Archaea_SRP links to Rfam database...	0.68	0.68	0.69	69	49041	33	4	27	2	33
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.83	0.84	90	47788	18	5	12	1	18
SRP_00208	Archaea_SRP links to Rfam database...	0.83	0.82	0.85	83	46567	18	2	13	3	18
SRP_00276	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	94	50612	16	5	10	1	16
SRP_00278	Archaea_SRP links to Rfam database...	0.72	0.72	0.71	76	45949	33	4	27	2	29
SRP_00321	Archaea_SRP links to Rfam database...	0.77	0.77	0.78	83	47479	27	3	21	3	25
SRP_00322	Archaea_SRP links to Rfam database...	0.60	0.60	0.61	65	48409	43	2	40	1	44
SRP_00323	Archaea_SRP links to Rfam database...	0.90	0.89	0.90	95	47173	14	0	10	4	12
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.44	0.45	42	49992	54	2	50	2	53
SRP_00332	Archaea_SRP links to Rfam database...	0.90	0.90	0.91	95	50299	15	1	8	6	11
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.56	0.56	53	44456	45	5	37	3	41

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1139
Total TN	2381706
Total FP	403
Total FP CONTRA	30
Total FP INCONS	344
Total FP COMP	29
Total FN	3071

Total Scores
MCC	0.451
Average MCC ± 95% Confidence Intervals	0.451 ± 0.045
Sensitivity	0.271
Positive Predictive Value	0.753
Nr of predictions	46

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]