CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Afold		Murlet(seed)
MCC	0.626	>	0.586
Average MCC ± 95% Confidence Intervals	0.611 ± 0.082	>	0.556 ± 0.105
Sensitivity	0.629	>	0.396
Positive Predictive Value	0.625	<	0.868
Total TP	1321	>	832
Total TN	1255328	<	1256483
Total FP	1054	>	170
Total FP CONTRA	148	>	13
Total FP INCONS	644	>	113
Total FP COMP	262	>	44
Total FN	779	<	1268
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of Afold and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and Murlet(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and Murlet(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and Murlet(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	1321
Total TN	1255328
Total FP	1054
Total FP CONTRA	148
Total FP INCONS	644
Total FP COMP	262
Total FN	779

Total Scores
MCC	0.626
Average MCC ± 95% Confidence Intervals	0.611 ± 0.082
Sensitivity	0.629
Positive Predictive Value	0.625
Nr of predictions	25

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.68	26	21283	26	7	5	14	13
RFA_00620	Telomerase-cil links to Rfam database...	0.64	0.62	0.67	24	21909	26	3	9	14	15
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00627	rne5 links to Rfam database...	0.48	0.47	0.48	41	56868	50	10	34	6	46
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00639	7SK links to Rfam database...	0.49	0.49	0.49	43	54528	61	8	36	17	44
RFA_00814	R2_retro_el links to Rfam database...	0.35	0.37	0.33	15	25155	42	7	23	12	26
RFA_00815	R2_retro_el links to Rfam database...	0.56	0.61	0.51	25	24482	35	8	16	11	16
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	32	0	1	31	2
RFA_00820	bicoid_3 links to Rfam database...	0.90	0.91	0.88	145	151361	34	1	18	15	15
RFA_00830	bicoid_3 links to Rfam database...	0.50	0.47	0.53	73	152490	110	5	60	45	81
SRP_00079	Plant_SRP links to Rfam database...	0.52	0.55	0.50	48	41809	53	8	40	5	40
SRP_00124	Metazoa_SRP links to Rfam database...	0.53	0.52	0.55	44	37048	38	5	31	2	41
SRP_00182	Plant_SRP links to Rfam database...	0.76	0.73	0.79	74	45962	21	3	17	1	27
SRP_00197	Archaea_SRP links to Rfam database...	0.24	0.24	0.25	24	49359	72	7	65	0	77
SRP_00199	Archaea_SRP links to Rfam database...	0.67	0.66	0.68	69	50939	34	2	30	2	36
SRP_00202	Archaea_SRP links to Rfam database...	0.95	0.93	0.96	109	54172	6	0	4	2	8
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.59	0.51	48	45961	50	11	36	3	34
SRP_00278	Archaea_SRP links to Rfam database...	0.72	0.72	0.71	76	45949	33	4	27	2	29
SRP_00322	Archaea_SRP links to Rfam database...	0.60	0.60	0.61	65	48409	43	2	40	1	44
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.56	0.56	53	44456	45	5	37	3	41
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	47	9	36	2	34

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP	832
Total TN	1256483
Total FP	170
Total FP CONTRA	13
Total FP INCONS	113
Total FP COMP	44
Total FN	1268

Total Scores
MCC	0.586
Average MCC ± 95% Confidence Intervals	0.556 ± 0.105
Sensitivity	0.396
Positive Predictive Value	0.868
Nr of predictions	25

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21321	0	0	0	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21945	0	0	0	0	39
RFA_00626	rne5 links to Rfam database...	0.81	0.66	1.00	57	56559	4	0	0	4	30
RFA_00627	rne5 links to Rfam database...	0.84	0.70	1.00	61	56892	5	0	0	5	26
RFA_00628	rne5 links to Rfam database...	0.83	0.69	1.00	59	57232	8	0	0	8	27
RFA_00630	rne5 links to Rfam database...	0.82	0.67	1.00	58	56895	4	0	0	4	29
RFA_00639	7SK links to Rfam database...	0.21	0.11	0.40	10	54590	15	4	11	0	77
RFA_00814	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	25171	4	0	3	1	15
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	1	0	0	1	13
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	23191	4	0	3	1	15
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	1	0	0	1	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
RFA_00820	bicoid_3 links to Rfam database...	0.71	0.56	0.89	90	151424	13	3	8	2	70
RFA_00830	bicoid_3 links to Rfam database...	0.59	0.45	0.78	70	152538	23	3	17	3	84
SRP_00079	Plant_SRP links to Rfam database...	0.54	0.33	0.88	29	41872	6	0	4	2	59
SRP_00124	Metazoa_SRP links to Rfam database...	0.15	0.09	0.24	8	37094	27	3	23	1	77
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.35	1.00	35	46021	1	0	0	1	66
SRP_00197	Archaea_SRP links to Rfam database...	0.47	0.28	0.80	28	49420	8	0	7	1	73
SRP_00199	Archaea_SRP links to Rfam database...	0.47	0.24	0.93	25	51013	3	0	2	1	80
SRP_00202	Archaea_SRP links to Rfam database...	0.48	0.25	0.94	29	54254	2	0	2	0	88
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.33	0.79	27	46022	9	0	7	2	55
SRP_00278	Archaea_SRP links to Rfam database...	0.53	0.30	0.94	31	46023	3	0	2	1	74
SRP_00322	Archaea_SRP links to Rfam database...	0.44	0.25	0.79	27	48482	8	0	7	1	82
SRP_00339	Archaea_SRP links to Rfam database...	0.49	0.32	0.77	30	44512	9	0	9	0	64
SRP_00340	Metazoa_SRP links to Rfam database...	0.44	0.27	0.73	22	41298	12	0	8	4	60

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]

Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

2. Individual counts for Murlet(seed) [ download as .csv ]