CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Afold		RNASampler(20)
MCC	0.570	>	0.537
Average MCC ± 95% Confidence Intervals	0.567 ± 0.069	>	0.494 ± 0.076
Sensitivity	0.570	>	0.354
Positive Predictive Value	0.571	<	0.818
Total TP	1961	>	1217
Total TN	1763682	<	1765629
Total FP	1684	>	344
Total FP CONTRA	196	>	44
Total FP INCONS	1277	>	226
Total FP COMP	211	>	74
Total FN	1481	<	2225
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Afold and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and RNASampler(20)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	1961
Total TN	1763682
Total FP	1684
Total FP CONTRA	196
Total FP INCONS	1277
Total FP COMP	211
Total FN	1481

Total Scores
MCC	0.570
Average MCC ± 95% Confidence Intervals	0.567 ± 0.069
Sensitivity	0.570
Positive Predictive Value	0.571
Nr of predictions	37

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.43	0.43	0.44	38	45364	54	5	44	5	51
ASE_00090	RNaseP_bact_a links to Rfam database...	0.46	0.47	0.47	47	55510	59	6	48	5	54
ASE_00135	RNaseP_bact_a links to Rfam database...	0.45	0.44	0.45	48	63084	63	8	50	5	61
ASE_00153	RNaseP_nuc links to Rfam database...	0.66	0.67	0.65	49	57555	68	2	24	42	24
ASE_00215	RNaseP_bact_a links to Rfam database...	0.54	0.51	0.57	50	48429	39	4	33	2	49
ASE_00305	RNaseP_bact_b links to Rfam database...	0.47	0.47	0.47	40	54529	56	10	36	10	45
ASE_00328	RNaseP_bact_b links to Rfam database...	0.40	0.41	0.40	46	72656	75	3	66	6	66
ASE_00361	RNaseP_bact_a links to Rfam database...	0.51	0.49	0.53	62	75349	59	7	48	4	65
ASE_00427	RNaseP_nuc links to Rfam database...	0.15	0.20	0.12	9	40678	81	17	51	13	37
ASE_00441	RNaseP_bact_a links to Rfam database...	0.77	0.72	0.83	81	64163	30	1	16	13	31
SRP_00006	Metazoa_SRP links to Rfam database...	0.82	0.81	0.84	82	45655	19	3	13	3	19
SRP_00011	Plant_SRP links to Rfam database...	0.43	0.42	0.45	44	46262	54	4	50	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.54	0.53	0.55	52	46265	48	8	35	5	47
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.68	0.70	0.67	61	37584	31	4	26	1	26
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.58	0.59	0.58	52	36766	46	4	34	8	36
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.74	0.75	0.73	66	36766	26	4	20	2	22
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.64	0.64	0.63	57	36225	37	4	29	4	32
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.60	0.60	0.60	52	36498	37	4	31	2	35
SRP_00086	Metazoa_SRP links to Rfam database...	0.71	0.71	0.70	71	44152	31	3	27	1	29
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.67	0.69	0.66	61	34098	32	3	29	0	28
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.82	0.81	0.84	73	35691	14	1	13	0	17
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.69	0.66	0.72	59	35429	25	1	22	2	31
SRP_00152	Plant_SRP links to Rfam database...	0.56	0.56	0.57	58	45651	45	1	43	1	45
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45348	103	15	88	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.83	0.78	0.87	80	45661	14	1	11	2	22
SRP_00181	Plant_SRP links to Rfam database...	0.33	0.31	0.35	32	45964	60	1	59	0	70
SRP_00182	Plant_SRP links to Rfam database...	0.76	0.73	0.79	74	45962	21	3	17	1	27
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.77	0.77	0.78	66	36230	25	1	18	6	20
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.55	0.55	0.56	48	36229	42	9	29	4	40
SRP_00317	Metazoa_SRP links to Rfam database...	0.93	0.89	0.98	87	45061	10	0	2	8	11
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.32	0.44	0.24	17	35173	76	26	29	21	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.73	0.71	0.76	65	35425	23	1	20	2	26
SRP_00347	Metazoa_SRP links to Rfam database...	0.82	0.80	0.84	77	46573	21	3	12	6	19
TMR_00046	tmRNA links to Rfam database...	0.47	0.48	0.46	46	62734	61	10	45	6	50
TMR_00048	tmRNA links to Rfam database...	0.35	0.37	0.34	35	64876	73	9	60	4	60
TMR_00458	tmRNA links to Rfam database...	0.22	0.22	0.23	20	63458	76	7	61	8	73
TMR_00568	tmRNA links to Rfam database...	0.57	0.57	0.58	56	60629	50	3	38	9	43

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1217
Total TN	1765629
Total FP	344
Total FP CONTRA	44
Total FP INCONS	226
Total FP COMP	74
Total FN	2225

Total Scores
MCC	0.537
Average MCC ± 95% Confidence Intervals	0.494 ± 0.076
Sensitivity	0.354
Positive Predictive Value	0.818
Nr of predictions	37

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]