CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	CMfinder(seed)		RNAwolf
MCC	0.454	>	0.427
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042	>	0.406 ± 0.077
Sensitivity	0.271	<	0.442
Positive Predictive Value	0.762	>	0.414
Total TP	1249	<	2036
Total TN	2623051	>	2619777
Total FP	419	<	3589
Total FP CONTRA	30	<	491
Total FP INCONS	360	<	2386
Total FP COMP	29	<	712
Total FN	3354	>	2567
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of CMfinder(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and RNAwolf).

^top

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

^top

2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

^top

Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP	2036
Total TN	2619777
Total FP	3589
Total FP CONTRA	491
Total FP INCONS	2386
Total FP COMP	712
Total FN	2567

Total Scores
MCC	0.427
Average MCC ± 95% Confidence Intervals	0.406 ± 0.077
Sensitivity	0.442
Positive Predictive Value	0.414
Nr of predictions	51

^top

2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.03	0.03	0.03	4	103598	147	24	114	9	111
CRW_00016	Intron_gpI links to Rfam database...	0.24	0.23	0.24	28	77305	101	10	78	13	92
CRW_00610	Intron_gpI links to Rfam database...	0.52	0.52	0.52	42	36234	53	4	35	14	39
CRW_00613	Intron_gpI links to Rfam database...	0.60	0.62	0.59	48	34898	50	1	33	16	30
CRW_00614	Intron_gpI links to Rfam database...	0.09	0.12	0.07	7	121673	167	34	57	76	50
CRW_00618	Intron_gpI links to Rfam database...	0.01	0.02	0.01	1	56208	107	13	58	36	60
CRW_00633	Intron_gpI links to Rfam database...	0.29	0.29	0.30	31	63442	76	12	61	3	75
CRW_00634	Intron_gpI links to Rfam database...	0.19	0.22	0.17	21	64493	110	25	81	4	73
CRW_00670	Intron_gpI links to Rfam database...	0.35	0.35	0.35	42	70006	81	12	65	4	78
CRW_00671	Intron_gpI links to Rfam database...	0.13	0.13	0.13	15	62723	100	11	86	3	102
CRW_00672	Intron_gpI links to Rfam database...	0.06	0.06	0.06	7	72276	114	17	90	7	104
CRW_00674	Intron_gpI links to Rfam database...	0.28	0.28	0.28	35	83310	106	12	79	15	89
CRW_00676	Intron_gpI links to Rfam database...	0.16	0.17	0.16	19	93407	113	22	80	11	96
CRW_00692	Intron_gpI links to Rfam database...	0.18	0.19	0.18	17	68539	100	16	63	21	73
PDB_00827	Intron_gpI links to Rfam database...	0.58	0.58	0.57	47	26946	37	6	29	2	34
RFA_00606	Telomerase-cil links to Rfam database...	0.39	0.41	0.36	16	21277	43	8	20	15	23
RFA_00620	Telomerase-cil links to Rfam database...	0.21	0.23	0.19	9	21898	49	10	28	11	30
RFA_00626	rne5 links to Rfam database...	0.08	0.09	0.08	8	56511	99	24	73	2	79
RFA_00627	rne5 links to Rfam database...	0.38	0.39	0.37	34	56862	73	13	44	16	53
RFA_00628	rne5 links to Rfam database...	0.58	0.57	0.59	49	57208	64	7	27	30	37
RFA_00630	rne5 links to Rfam database...	0.48	0.47	0.49	41	56869	66	9	34	23	46
RFA_00639	7SK links to Rfam database...	0.10	0.10	0.09	9	54519	94	13	74	7	78
RFA_00814	R2_retro_el links to Rfam database...	0.20	0.22	0.18	9	25149	62	12	30	20	32
RFA_00815	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	24477	47	14	18	15	19
RFA_00816	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	23162	66	17	41	8	41
RFA_00817	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	21892	57	12	41	4	41
RFA_00818	R2_retro_el links to Rfam database...	0.25	0.27	0.23	11	20253	51	12	25	14	30
RFA_00819	R2_retro_el links to Rfam database...	0.16	0.17	0.16	7	27921	70	6	32	32	34
SRP_00016	Archaea_SRP links to Rfam database...	0.79	0.81	0.78	88	47782	44	1	24	19	21
SRP_00130	Archaea_SRP links to Rfam database...	0.21	0.22	0.20	21	49666	85	6	77	2	76
SRP_00142	Archaea_SRP links to Rfam database...	0.21	0.23	0.20	21	45949	92	12	74	6	72
SRP_00143	Archaea_SRP links to Rfam database...	0.42	0.44	0.40	44	49660	75	6	60	9	57
SRP_00144	Archaea_SRP links to Rfam database...	0.36	0.38	0.34	36	46560	80	8	61	11	58
SRP_00197	Archaea_SRP links to Rfam database...	0.36	0.37	0.36	37	49353	73	6	59	8	64
SRP_00198	Archaea_SRP links to Rfam database...	0.13	0.14	0.13	14	50935	101	10	81	10	89
SRP_00199	Archaea_SRP links to Rfam database...	0.18	0.19	0.18	20	50930	94	7	83	4	85
SRP_00201	Archaea_SRP links to Rfam database...	0.78	0.79	0.77	88	47780	40	7	20	13	23
SRP_00202	Archaea_SRP links to Rfam database...	0.85	0.86	0.83	101	54163	31	5	16	10	16
SRP_00203	Archaea_SRP links to Rfam database...	0.72	0.75	0.69	79	48714	53	2	33	18	26
SRP_00204	Archaea_SRP links to Rfam database...	0.71	0.69	0.74	70	49046	45	1	24	20	32
SRP_00206	Archaea_SRP links to Rfam database...	0.74	0.75	0.73	81	47784	43	6	24	13	27
SRP_00208	Archaea_SRP links to Rfam database...	0.80	0.80	0.80	81	46564	36	3	17	16	20
SRP_00255	Archaea_SRP links to Rfam database...	0.56	0.59	0.54	55	47485	59	7	39	13	39
SRP_00276	Archaea_SRP links to Rfam database...	0.80	0.80	0.80	88	50611	41	1	21	19	22
SRP_00278	Archaea_SRP links to Rfam database...	0.69	0.70	0.69	74	45948	45	2	32	11	31
SRP_00321	Archaea_SRP links to Rfam database...	0.73	0.72	0.74	78	47480	39	4	24	11	30
SRP_00322	Archaea_SRP links to Rfam database...	0.73	0.72	0.73	79	48408	38	3	26	9	30
SRP_00323	Archaea_SRP links to Rfam database...	0.74	0.73	0.76	78	47175	33	1	24	8	29
SRP_00330	Archaea_SRP links to Rfam database...	0.64	0.69	0.60	66	49976	58	9	35	14	29
SRP_00332	Archaea_SRP links to Rfam database...	0.88	0.88	0.89	93	50298	34	1	11	22	13
SRP_00339	Archaea_SRP links to Rfam database...	0.68	0.69	0.67	65	44454	47	7	25	15	29

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

2. Individual counts for RNAwolf [ download as .csv ]