CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CMfinder(seed)		Vsfold4
MCC	0.456	>	0.271
Average MCC ± 95% Confidence Intervals	0.457 ± 0.044	>	0.262 ± 0.045
Sensitivity	0.275	>	0.251
Positive Predictive Value	0.759	>	0.295
Total TP	1219	>	1110
Total TN	2397572	>	2395415
Total FP	410	<	2823
Total FP CONTRA	30	<	339
Total FP INCONS	358	<	2315
Total FP COMP	22	<	169
Total FN	3212	<	3321
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CMfinder(seed) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold4).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold4).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold4).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1219
Total TN	2397572
Total FP	410
Total FP CONTRA	30
Total FP INCONS	358
Total FP COMP	22
Total FN	3212

Total Scores
MCC	0.456
Average MCC ± 95% Confidence Intervals	0.457 ± 0.044
Sensitivity	0.275
Positive Predictive Value	0.759
Nr of predictions	49

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	1110
Total TN	2395415
Total FP	2823
Total FP CONTRA	339
Total FP INCONS	2315
Total FP COMP	169
Total FN	3321

Total Scores
MCC	0.271
Average MCC ± 95% Confidence Intervals	0.262 ± 0.045
Sensitivity	0.251
Positive Predictive Value	0.295
Nr of predictions	49

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.53	0.46	0.61	55	77331	44	4	31	9	65
CRW_00610	Intron_gpI links to Rfam database...	0.40	0.36	0.46	29	36252	37	5	29	3	52
CRW_00613	Intron_gpI links to Rfam database...	0.48	0.42	0.54	33	34919	34	2	26	6	45
CRW_00618	Intron_gpI links to Rfam database...	0.33	0.31	0.35	19	56225	57	6	30	21	42
CRW_00633	Intron_gpI links to Rfam database...	0.38	0.35	0.42	37	63457	52	6	46	0	69
CRW_00634	Intron_gpI links to Rfam database...	0.29	0.28	0.30	26	64533	68	8	53	7	68
CRW_00670	Intron_gpI links to Rfam database...	0.37	0.34	0.41	41	70025	60	3	56	1	79
CRW_00671	Intron_gpI links to Rfam database...	0.55	0.50	0.60	59	62736	40	2	38	0	58
CRW_00672	Intron_gpI links to Rfam database...	0.30	0.29	0.32	32	72291	71	14	53	4	79
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.26	0.33	32	83339	67	8	57	2	92
CRW_00676	Intron_gpI links to Rfam database...	0.34	0.34	0.34	39	93413	80	20	56	4	76
CRW_00692	Intron_gpI links to Rfam database...	0.26	0.24	0.28	22	68555	62	20	38	4	68
PDB_00827	Intron_gpI links to Rfam database...	0.65	0.54	0.79	44	26972	13	0	12	1	37
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.36	0.33	14	21278	40	5	24	11	25
RFA_00620	Telomerase-cil links to Rfam database...	0.22	0.23	0.21	9	21903	40	11	22	7	30
RFA_00626	rne5 links to Rfam database...	0.20	0.18	0.22	16	56543	61	11	46	4	71
RFA_00627	rne5 links to Rfam database...	0.23	0.22	0.24	19	56874	63	13	47	3	68
RFA_00628	rne5 links to Rfam database...	0.24	0.22	0.26	19	57218	64	8	46	10	67
RFA_00630	rne5 links to Rfam database...	0.30	0.29	0.32	25	56875	58	3	50	5	62
RFA_00639	7SK links to Rfam database...	0.23	0.22	0.24	19	54537	63	12	47	4	68
RFA_00814	R2_retro_el links to Rfam database...	0.41	0.39	0.43	16	25163	33	3	18	12	25
RFA_00815	R2_retro_el links to Rfam database...	0.11	0.12	0.10	5	24483	47	6	37	4	36
RFA_00816	R2_retro_el links to Rfam database...	0.12	0.12	0.13	5	23181	42	9	25	8	36
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.11	5	21898	42	16	26	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20265	46	10	26	10	41
RFA_00819	R2_retro_el links to Rfam database...	0.20	0.20	0.21	8	27928	45	6	24	15	33
SRP_00016	Archaea_SRP links to Rfam database...	0.15	0.13	0.18	14	47816	66	1	64	1	95
SRP_00130	Archaea_SRP links to Rfam database...	0.10	0.09	0.12	9	49695	67	7	59	1	88
SRP_00142	Archaea_SRP links to Rfam database...	0.25	0.24	0.26	22	45971	65	6	57	2	71
SRP_00143	Archaea_SRP links to Rfam database...	0.21	0.20	0.24	20	49685	65	3	62	0	81
SRP_00144	Archaea_SRP links to Rfam database...	0.18	0.17	0.20	16	46584	67	5	60	2	78
SRP_00197	Archaea_SRP links to Rfam database...	0.08	0.07	0.09	7	49377	71	8	63	0	94
SRP_00198	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	50960	80	8	72	0	103
SRP_00199	Archaea_SRP links to Rfam database...	0.16	0.15	0.18	16	50949	75	5	70	0	89
SRP_00201	Archaea_SRP links to Rfam database...	0.29	0.26	0.32	29	47805	62	5	56	1	82
SRP_00202	Archaea_SRP links to Rfam database...	0.58	0.56	0.61	65	54179	41	3	38	0	52
SRP_00203	Archaea_SRP links to Rfam database...	0.28	0.28	0.30	29	48730	70	6	63	1	76
SRP_00204	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	49070	72	8	63	1	102
SRP_00206	Archaea_SRP links to Rfam database...	0.36	0.31	0.41	34	47812	49	3	46	0	74
SRP_00208	Archaea_SRP links to Rfam database...	0.29	0.25	0.33	25	46590	51	5	45	1	76
SRP_00255	Archaea_SRP links to Rfam database...	0.21	0.21	0.22	20	47495	71	10	61	0	74
SRP_00276	Archaea_SRP links to Rfam database...	0.14	0.13	0.16	14	50632	75	9	66	0	96
SRP_00278	Archaea_SRP links to Rfam database...	0.13	0.12	0.14	13	45965	78	5	73	0	92
SRP_00321	Archaea_SRP links to Rfam database...	0.24	0.20	0.28	22	47506	59	6	52	1	86
SRP_00322	Archaea_SRP links to Rfam database...	0.18	0.17	0.19	18	48423	75	5	70	0	91
SRP_00323	Archaea_SRP links to Rfam database...	0.64	0.59	0.71	63	47189	28	1	25	2	44
SRP_00330	Archaea_SRP links to Rfam database...	0.09	0.08	0.10	8	50005	73	8	65	0	87
SRP_00332	Archaea_SRP links to Rfam database...	0.23	0.21	0.25	22	50316	66	2	63	1	84
SRP_00339	Archaea_SRP links to Rfam database...	0.18	0.17	0.19	16	44467	68	9	59	0	78

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]