CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CMfinder(seed)		Vsfold5
MCC	0.456	>	0.254
Average MCC ± 95% Confidence Intervals	0.457 ± 0.044	>	0.253 ± 0.033
Sensitivity	0.275	>	0.246
Positive Predictive Value	0.759	>	0.264
Total TP	1219	>	1091
Total TN	2397572	>	2395043
Total FP	410	<	3220
Total FP CONTRA	30	<	438
Total FP INCONS	358	<	2607
Total FP COMP	22	<	175
Total FN	3212	<	3340
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CMfinder(seed) and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold5).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold5).
Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and Vsfold5).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1219
Total TN	2397572
Total FP	410
Total FP CONTRA	30
Total FP INCONS	358
Total FP COMP	22
Total FN	3212

Total Scores
MCC	0.456
Average MCC ± 95% Confidence Intervals	0.457 ± 0.044
Sensitivity	0.275
Positive Predictive Value	0.759
Nr of predictions	49

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP	1091
Total TN	2395043
Total FP	3220
Total FP CONTRA	438
Total FP INCONS	2607
Total FP COMP	175
Total FN	3340

Total Scores
MCC	0.254
Average MCC ± 95% Confidence Intervals	0.253 ± 0.033
Sensitivity	0.246
Positive Predictive Value	0.264
Nr of predictions	49

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.40	0.38	0.42	45	77315	67	4	57	6	75
CRW_00610	Intron_gpI links to Rfam database...	0.29	0.28	0.30	23	36238	57	6	48	3	58
CRW_00613	Intron_gpI links to Rfam database...	0.48	0.46	0.51	36	34909	41	2	33	6	42
CRW_00618	Intron_gpI links to Rfam database...	0.24	0.26	0.23	16	56210	76	9	45	22	45
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63546	0	0	0	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.32	0.33	0.32	31	64523	75	10	56	9	63
CRW_00670	Intron_gpI links to Rfam database...	0.40	0.38	0.43	45	70020	61	3	57	1	75
CRW_00671	Intron_gpI links to Rfam database...	0.29	0.26	0.33	31	62740	64	2	62	0	86
CRW_00672	Intron_gpI links to Rfam database...	0.39	0.40	0.39	44	72278	70	14	54	2	67
CRW_00674	Intron_gpI links to Rfam database...	0.33	0.31	0.36	38	83330	74	5	63	6	86
CRW_00676	Intron_gpI links to Rfam database...	0.34	0.36	0.33	41	93405	88	19	63	6	74
CRW_00692	Intron_gpI links to Rfam database...	0.36	0.38	0.34	34	68534	67	21	46	0	56
PDB_00827	Intron_gpI links to Rfam database...	0.51	0.42	0.62	34	26973	22	0	21	1	47
RFA_00606	Telomerase-cil links to Rfam database...	0.41	0.49	0.35	19	21267	43	15	20	8	20
RFA_00620	Telomerase-cil links to Rfam database...	0.23	0.23	0.24	9	21907	41	6	23	12	30
RFA_00626	rne5 links to Rfam database...	0.31	0.31	0.32	27	56531	62	15	43	4	60
RFA_00627	rne5 links to Rfam database...	0.26	0.26	0.26	23	56863	69	16	51	2	64
RFA_00628	rne5 links to Rfam database...	0.34	0.35	0.34	30	57202	66	13	46	7	56
RFA_00630	rne5 links to Rfam database...	0.27	0.29	0.26	25	56857	78	13	58	7	62
RFA_00639	7SK links to Rfam database...	0.06	0.06	0.06	5	54526	88	15	69	4	82
RFA_00814	R2_retro_el links to Rfam database...	0.31	0.34	0.29	14	25151	46	10	25	11	27
RFA_00815	R2_retro_el links to Rfam database...	0.22	0.24	0.20	10	24480	46	18	23	5	31
RFA_00816	R2_retro_el links to Rfam database...	0.31	0.32	0.30	13	23177	38	12	18	8	28
RFA_00817	R2_retro_el links to Rfam database...	0.32	0.34	0.30	14	21898	35	10	23	2	27
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.20	0.19	8	20258	41	8	27	6	33
RFA_00819	R2_retro_el links to Rfam database...	0.27	0.27	0.28	11	27926	53	6	23	24	30
SRP_00016	Archaea_SRP links to Rfam database...	0.14	0.13	0.15	14	47800	82	3	78	1	95
SRP_00130	Archaea_SRP links to Rfam database...	0.11	0.10	0.12	10	49686	75	10	64	1	87
SRP_00142	Archaea_SRP links to Rfam database...	0.25	0.26	0.25	24	45959	75	10	63	2	69
SRP_00143	Archaea_SRP links to Rfam database...	0.20	0.20	0.20	20	49668	82	4	78	0	81
SRP_00144	Archaea_SRP links to Rfam database...	0.15	0.14	0.16	13	46582	71	11	59	1	81
SRP_00197	Archaea_SRP links to Rfam database...	0.23	0.23	0.24	23	49359	73	9	64	0	78
SRP_00198	Archaea_SRP links to Rfam database...	0.11	0.11	0.13	11	50953	76	11	65	0	92
SRP_00199	Archaea_SRP links to Rfam database...	0.24	0.24	0.25	25	50938	77	10	67	0	80
SRP_00201	Archaea_SRP links to Rfam database...	0.27	0.26	0.28	29	47792	74	12	62	0	82
SRP_00202	Archaea_SRP links to Rfam database...	0.51	0.50	0.53	59	54173	53	8	45	0	58
SRP_00203	Archaea_SRP links to Rfam database...	0.19	0.19	0.19	20	48725	84	4	79	1	85
SRP_00204	Archaea_SRP links to Rfam database...	0.06	0.06	0.07	6	49055	80	11	69	0	96
SRP_00206	Archaea_SRP links to Rfam database...	0.22	0.20	0.24	22	47803	74	5	65	4	86
SRP_00208	Archaea_SRP links to Rfam database...	0.09	0.09	0.10	9	46574	83	9	73	1	92
SRP_00255	Archaea_SRP links to Rfam database...	0.22	0.22	0.22	21	47490	75	8	67	0	73
SRP_00276	Archaea_SRP links to Rfam database...	0.25	0.25	0.27	27	50620	75	8	66	1	83
SRP_00278	Archaea_SRP links to Rfam database...	0.17	0.16	0.17	17	45958	81	7	74	0	88
SRP_00321	Archaea_SRP links to Rfam database...	0.15	0.14	0.16	15	47491	80	6	74	0	93
SRP_00322	Archaea_SRP links to Rfam database...	0.16	0.16	0.17	17	48417	82	4	78	0	92
SRP_00323	Archaea_SRP links to Rfam database...	0.23	0.21	0.25	23	47187	69	2	66	1	84
SRP_00330	Archaea_SRP links to Rfam database...	0.12	0.13	0.12	12	49989	85	13	72	0	83
SRP_00332	Archaea_SRP links to Rfam database...	0.29	0.29	0.29	31	50297	75	8	67	0	75
SRP_00339	Archaea_SRP links to Rfam database...	0.19	0.18	0.19	17	44463	71	13	58	0	77

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]

Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

2. Individual counts for Vsfold5 [ download as .csv ]