CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(seed)		PPfold(seed)
MCC	0.731	>	0.716
Average MCC ± 95% Confidence Intervals	0.757 ± 0.074	>	0.749 ± 0.077
Sensitivity	0.667	>	0.652
Positive Predictive Value	0.802	>	0.787
Total TP	1253	>	1226
Total TN	1050321	<	1050327
Total FP	473	>	467
Total FP CONTRA	47	<	48
Total FP INCONS	263	<	283
Total FP COMP	163	>	136
Total FN	626	<	653
P-value	5.19332990918e-08

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Performance plots

Comparison of performance of CentroidAlifold(seed) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and PPfold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and PPfold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and PPfold(seed)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	1253
Total TN	1050321
Total FP	473
Total FP CONTRA	47
Total FP INCONS	263
Total FP COMP	163
Total FN	626

Total Scores
MCC	0.731
Average MCC ± 95% Confidence Intervals	0.757 ± 0.074
Sensitivity	0.667
Positive Predictive Value	0.802
Nr of predictions	23

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.98	0.95	1.00	83	56533	8	0	0	8	4
RFA_00627	rne5 links to Rfam database...	0.98	0.97	1.00	84	56869	10	0	0	10	3
RFA_00628	rne5 links to Rfam database...	0.98	0.95	1.00	82	57209	12	0	0	12	4
RFA_00630	rne5 links to Rfam database...	0.93	0.90	0.96	78	56872	16	0	3	13	9
RFA_00805	RNAIII links to Rfam database...	0.64	0.41	1.00	61	133325	1	0	0	1	89
RFA_00814	R2_retro_el links to Rfam database...	0.91	0.83	1.00	34	25166	1	0	0	1	7
RFA_00816	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	23184	1	0	0	1	5
RFA_00817	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	21910	1	0	0	1	6
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	1	0	0	1	5
RFA_00819	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	27930	1	0	0	1	5
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.68	0.81	60	41831	29	0	14	15	28
SRP_00099	Plant_SRP links to Rfam database...	0.61	0.58	0.64	55	44764	35	2	29	4	40
SRP_00124	Metazoa_SRP links to Rfam database...	0.64	0.58	0.72	49	37060	31	3	16	12	36
SRP_00182	Plant_SRP links to Rfam database...	0.87	0.79	0.95	80	45972	11	0	4	7	21
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.51	0.55	42	45979	47	8	27	12	40
SRP_00252	Metazoa_SRP links to Rfam database...	0.62	0.58	0.65	52	49061	40	5	23	12	37
SRP_00253	Metazoa_SRP links to Rfam database...	0.62	0.59	0.65	53	49374	38	5	23	10	37
SRP_00257	Metazoa_SRP links to Rfam database...	0.54	0.47	0.62	51	50958	33	5	26	2	57
SRP_00260	Metazoa_SRP links to Rfam database...	0.58	0.52	0.64	52	47814	34	5	24	5	48
SRP_00328	Metazoa_SRP links to Rfam database...	0.59	0.54	0.65	46	39550	30	5	20	5	39
SRP_00329	Metazoa_SRP links to Rfam database...	0.71	0.64	0.79	54	39835	24	2	12	10	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.65	0.59	0.73	51	37605	26	2	17	7	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.52	0.59	43	41255	43	5	25	13	39

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]