CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidFold		CMfinder(seed)
MCC	0.692	>	0.454
Average MCC ± 95% Confidence Intervals	0.669 ± 0.052	>	0.456 ± 0.042
Sensitivity	0.651	>	0.271
Positive Predictive Value	0.738	<	0.762
Total TP	2996	>	1249
Total TN	2620628	<	2623051
Total FP	1400	>	419
Total FP CONTRA	193	>	30
Total FP INCONS	873	>	360
Total FP COMP	334	>	29
Total FN	1607	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and CMfinder(seed)).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP	2996
Total TN	2620628
Total FP	1400
Total FP CONTRA	193
Total FP INCONS	873
Total FP COMP	334
Total FN	1607

Total Scores
MCC	0.692
Average MCC ± 95% Confidence Intervals	0.669 ± 0.052
Sensitivity	0.651
Positive Predictive Value	0.738
Nr of predictions	51

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.45	0.32	0.63	37	103681	42	7	15	20	78
CRW_00016	Intron_gpI links to Rfam database...	0.74	0.66	0.84	79	77327	27	0	15	12	41
CRW_00610	Intron_gpI links to Rfam database...	0.57	0.52	0.63	42	36248	26	7	18	1	39
CRW_00613	Intron_gpI links to Rfam database...	0.78	0.72	0.85	56	34914	17	1	9	7	22
CRW_00614	Intron_gpI links to Rfam database...	0.23	0.23	0.24	13	121716	103	6	36	61	44
CRW_00618	Intron_gpI links to Rfam database...	0.23	0.21	0.24	13	56226	58	6	35	17	48
CRW_00633	Intron_gpI links to Rfam database...	0.65	0.56	0.77	59	63469	20	2	16	2	47
CRW_00634	Intron_gpI links to Rfam database...	0.53	0.47	0.59	44	64546	31	11	19	1	50
CRW_00670	Intron_gpI links to Rfam database...	0.77	0.63	0.93	76	70043	6	0	6	0	44
CRW_00671	Intron_gpI links to Rfam database...	0.71	0.64	0.78	75	62739	23	1	20	2	42
CRW_00672	Intron_gpI links to Rfam database...	0.58	0.49	0.70	54	72313	26	7	16	3	57
CRW_00674	Intron_gpI links to Rfam database...	0.71	0.63	0.80	78	83339	24	5	14	5	46
CRW_00676	Intron_gpI links to Rfam database...	0.47	0.46	0.48	53	93418	61	14	43	4	62
CRW_00692	Intron_gpI links to Rfam database...	0.49	0.44	0.53	40	68560	36	15	20	1	50
PDB_00827	Intron_gpI links to Rfam database...	0.71	0.54	0.94	44	26981	5	0	3	2	37
RFA_00606	Telomerase-cil links to Rfam database...	0.57	0.51	0.63	20	21289	21	7	5	9	19
RFA_00620	Telomerase-cil links to Rfam database...	0.68	0.56	0.81	22	21918	20	0	5	15	17
RFA_00626	rne5 links to Rfam database...	0.90	0.86	0.95	75	56537	20	0	4	16	12
RFA_00627	rne5 links to Rfam database...	0.87	0.82	0.93	71	56877	18	0	5	13	16
RFA_00628	rne5 links to Rfam database...	0.90	0.86	0.94	74	57212	20	0	5	15	12
RFA_00630	rne5 links to Rfam database...	0.80	0.76	0.85	66	56875	25	0	12	13	21
RFA_00639	7SK links to Rfam database...	0.61	0.55	0.69	48	54545	29	3	19	7	39
RFA_00814	R2_retro_el links to Rfam database...	0.70	0.51	0.95	21	25178	6	0	1	5	20
RFA_00815	R2_retro_el links to Rfam database...	0.61	0.61	0.61	25	24490	22	1	15	6	16
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.73	0.77	30	23181	14	8	1	5	11
RFA_00817	R2_retro_el links to Rfam database...	0.13	0.12	0.14	5	21909	31	9	22	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.54	0.54	0.54	22	20260	26	11	8	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.49	0.37	0.65	15	27943	23	0	8	15	26
SRP_00016	Archaea_SRP links to Rfam database...	0.91	0.89	0.93	97	47791	9	0	7	2	12
SRP_00130	Archaea_SRP links to Rfam database...	0.68	0.67	0.68	65	49675	35	4	26	5	32
SRP_00142	Archaea_SRP links to Rfam database...	0.54	0.54	0.55	50	45965	43	5	36	2	43
SRP_00143	Archaea_SRP links to Rfam database...	0.75	0.74	0.76	75	49671	31	1	23	7	26
SRP_00144	Archaea_SRP links to Rfam database...	0.72	0.71	0.73	67	46573	32	1	24	7	27
SRP_00197	Archaea_SRP links to Rfam database...	0.36	0.28	0.46	28	49394	33	7	26	0	73
SRP_00198	Archaea_SRP links to Rfam database...	0.43	0.38	0.48	39	50959	43	2	40	1	64
SRP_00199	Archaea_SRP links to Rfam database...	0.60	0.54	0.67	57	50955	29	3	25	1	48
SRP_00201	Archaea_SRP links to Rfam database...	0.85	0.84	0.87	93	47788	16	5	9	2	18
SRP_00202	Archaea_SRP links to Rfam database...	0.90	0.88	0.91	103	54172	11	0	10	1	14
SRP_00203	Archaea_SRP links to Rfam database...	0.73	0.74	0.71	78	48718	41	2	30	9	27
SRP_00204	Archaea_SRP links to Rfam database...	0.72	0.72	0.72	73	49039	30	6	23	1	29
SRP_00206	Archaea_SRP links to Rfam database...	0.85	0.86	0.85	93	47785	19	6	11	2	15
SRP_00208	Archaea_SRP links to Rfam database...	0.85	0.85	0.84	86	46563	18	3	13	2	15
SRP_00255	Archaea_SRP links to Rfam database...	0.80	0.81	0.78	76	47489	26	2	19	5	18
SRP_00276	Archaea_SRP links to Rfam database...	0.87	0.86	0.87	95	50612	16	5	9	2	15
SRP_00278	Archaea_SRP links to Rfam database...	0.75	0.74	0.75	78	45952	28	4	22	2	27
SRP_00321	Archaea_SRP links to Rfam database...	0.69	0.70	0.68	76	47475	37	3	32	2	32
SRP_00322	Archaea_SRP links to Rfam database...	0.89	0.90	0.89	98	48406	14	0	12	2	11
SRP_00323	Archaea_SRP links to Rfam database...	0.94	0.94	0.94	101	47171	9	0	6	3	6
SRP_00330	Archaea_SRP links to Rfam database...	0.75	0.75	0.76	71	49993	28	1	21	6	24
SRP_00332	Archaea_SRP links to Rfam database...	0.70	0.72	0.68	76	50292	36	8	27	1	30
SRP_00339	Archaea_SRP links to Rfam database...	0.68	0.68	0.67	64	44456	36	4	27	5	30

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

2. Individual counts for CentroidFold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]