CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidHomfold‑LAST		CMfinder(seed)
MCC	0.731	>	0.454
Average MCC ± 95% Confidence Intervals	0.721 ± 0.043	>	0.456 ± 0.042
Sensitivity	0.587	>	0.271
Positive Predictive Value	0.911	>	0.762
Total TP	2703	>	1249
Total TN	2621723	<	2623051
Total FP	434	>	419
Total FP CONTRA	35	>	30
Total FP INCONS	229	<	360
Total FP COMP	170	>	29
Total FN	1900	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidHomfold-LAST and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and CMfinder(seed)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP	2703
Total TN	2621723
Total FP	434
Total FP CONTRA	35
Total FP INCONS	229
Total FP COMP	170
Total FN	1900

Total Scores
MCC	0.731
Average MCC ± 95% Confidence Intervals	0.721 ± 0.043
Sensitivity	0.587
Positive Predictive Value	0.911
Nr of predictions	51

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.62	0.42	0.92	48	103688	4	0	4	0	67
CRW_00016	Intron_gpI links to Rfam database...	0.70	0.50	0.97	60	77359	2	0	2	0	60
CRW_00610	Intron_gpI links to Rfam database...	0.66	0.46	0.95	37	36276	2	0	2	0	44
CRW_00613	Intron_gpI links to Rfam database...	0.74	0.55	1.00	43	34937	0	0	0	0	35
CRW_00614	Intron_gpI links to Rfam database...	0.21	0.18	0.25	10	121731	73	7	23	43	47
CRW_00618	Intron_gpI links to Rfam database...	0.38	0.25	0.58	15	56254	20	1	10	9	46
CRW_00633	Intron_gpI links to Rfam database...	0.64	0.42	0.98	45	63500	2	1	0	1	61
CRW_00634	Intron_gpI links to Rfam database...	0.69	0.54	0.88	51	64562	7	1	6	0	43
CRW_00670	Intron_gpI links to Rfam database...	0.69	0.50	0.95	60	70062	3	0	3	0	60
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.48	0.92	56	62774	5	1	4	0	61
CRW_00672	Intron_gpI links to Rfam database...	0.69	0.50	0.96	55	72333	3	0	2	1	56
CRW_00674	Intron_gpI links to Rfam database...	0.76	0.57	1.00	71	83365	1	0	0	1	53
CRW_00676	Intron_gpI links to Rfam database...	0.73	0.55	0.98	63	93464	3	0	1	2	52
CRW_00692	Intron_gpI links to Rfam database...	0.82	0.70	0.95	63	68569	3	0	3	0	27
PDB_00827	Intron_gpI links to Rfam database...	0.73	0.54	0.98	44	26983	2	0	1	1	37
RFA_00606	Telomerase-cil links to Rfam database...	0.72	0.69	0.75	27	21285	17	7	2	8	12
RFA_00620	Telomerase-cil links to Rfam database...	0.23	0.15	0.35	6	21928	16	1	10	5	33
RFA_00626	rne5 links to Rfam database...	0.85	0.79	0.92	69	56541	13	1	5	7	18
RFA_00627	rne5 links to Rfam database...	0.86	0.75	0.98	65	56887	13	0	1	12	22
RFA_00628	rne5 links to Rfam database...	0.86	0.78	0.94	67	57220	7	1	3	3	19
RFA_00630	rne5 links to Rfam database...	0.87	0.83	0.92	72	56875	10	1	5	4	15
RFA_00639	7SK links to Rfam database...	0.51	0.46	0.56	40	54544	38	3	28	7	47
RFA_00814	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	25162	6	0	0	6	3
RFA_00815	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	24496	1	0	0	1	6
RFA_00816	R2_retro_el links to Rfam database...	0.80	0.63	1.00	26	23194	1	0	0	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.59	0.80	24	21915	9	2	4	3	17
RFA_00818	R2_retro_el links to Rfam database...	0.57	0.54	0.61	22	20265	18	8	6	4	19
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.93	0.97	38	27927	15	0	1	14	3
SRP_00016	Archaea_SRP links to Rfam database...	0.67	0.47	0.96	51	47842	3	0	2	1	58
SRP_00130	Archaea_SRP links to Rfam database...	0.57	0.38	0.86	37	49727	7	0	6	1	60
SRP_00142	Archaea_SRP links to Rfam database...	0.80	0.73	0.87	68	45978	12	0	10	2	25
SRP_00143	Archaea_SRP links to Rfam database...	0.83	0.75	0.93	76	49688	10	0	6	4	25
SRP_00144	Archaea_SRP links to Rfam database...	0.86	0.79	0.94	74	46586	8	0	5	3	20
SRP_00197	Archaea_SRP links to Rfam database...	0.70	0.51	0.96	52	49401	2	0	2	0	49
SRP_00198	Archaea_SRP links to Rfam database...	0.72	0.54	0.97	56	50982	2	0	2	0	47
SRP_00199	Archaea_SRP links to Rfam database...	0.68	0.50	0.95	52	50985	3	0	3	0	53
SRP_00201	Archaea_SRP links to Rfam database...	0.71	0.52	0.97	58	47835	3	0	2	1	53
SRP_00202	Archaea_SRP links to Rfam database...	0.77	0.62	0.95	73	54208	6	0	4	2	44
SRP_00203	Archaea_SRP links to Rfam database...	0.71	0.61	0.83	64	48751	18	0	13	5	41
SRP_00204	Archaea_SRP links to Rfam database...	0.73	0.59	0.91	60	49075	7	0	6	1	42
SRP_00206	Archaea_SRP links to Rfam database...	0.79	0.65	0.97	70	47823	3	0	2	1	38
SRP_00208	Archaea_SRP links to Rfam database...	0.81	0.66	0.99	67	46597	2	0	1	1	34
SRP_00255	Archaea_SRP links to Rfam database...	0.55	0.31	0.97	29	47556	3	0	1	2	65
SRP_00276	Archaea_SRP links to Rfam database...	0.82	0.69	0.97	76	50643	3	0	2	1	34
SRP_00278	Archaea_SRP links to Rfam database...	0.57	0.34	0.95	36	46018	3	0	2	1	69
SRP_00321	Archaea_SRP links to Rfam database...	0.70	0.52	0.93	56	47526	5	0	4	1	52
SRP_00322	Archaea_SRP links to Rfam database...	0.87	0.82	0.94	89	48421	7	0	6	1	20
SRP_00323	Archaea_SRP links to Rfam database...	0.88	0.83	0.93	89	47182	10	0	7	3	18
SRP_00330	Archaea_SRP links to Rfam database...	0.78	0.65	0.94	62	50020	6	0	4	2	33
SRP_00332	Archaea_SRP links to Rfam database...	0.85	0.75	0.96	79	50321	4	0	3	1	27
SRP_00339	Archaea_SRP links to Rfam database...	0.86	0.84	0.89	79	44462	13	0	10	3	15

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]