CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidHomfold‑LAST		RNASampler(20)
MCC	0.717	>	0.565
Average MCC ± 95% Confidence Intervals	0.703 ± 0.030	>	0.539 ± 0.043
Sensitivity	0.582	>	0.413
Positive Predictive Value	0.885	>	0.772
Total TP	4334	>	3079
Total TN	4281182	<	4282091
Total FP	892	<	1146
Total FP CONTRA	94	<	258
Total FP INCONS	467	<	649
Total FP COMP	331	>	239
Total FN	3115	<	4370
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidHomfold-LAST and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(20)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP	4334
Total TN	4281182
Total FP	892
Total FP CONTRA	94
Total FP INCONS	467
Total FP COMP	331
Total FN	3115

Total Scores
MCC	0.717
Average MCC ± 95% Confidence Intervals	0.703 ± 0.030
Sensitivity	0.582
Positive Predictive Value	0.885
Nr of predictions	78

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.75	0.61	0.93	54	45393	8	0	4	4	35
ASE_00090	RNaseP_bact_a links to Rfam database...	0.69	0.60	0.78	61	55533	17	1	16	0	40
ASE_00135	RNaseP_bact_a links to Rfam database...	0.64	0.46	0.89	50	63134	7	1	5	1	59
ASE_00153	RNaseP_nuc links to Rfam database...	0.54	0.48	0.60	35	57572	43	2	21	20	38
ASE_00215	RNaseP_bact_a links to Rfam database...	0.62	0.40	0.95	40	48474	3	1	1	1	59
ASE_00305	RNaseP_bact_b links to Rfam database...	0.81	0.71	0.94	60	54551	11	0	4	7	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.80	0.66	0.97	74	72695	9	0	2	7	38
ASE_00361	RNaseP_bact_a links to Rfam database...	0.65	0.43	0.96	55	75409	4	0	2	2	72
ASE_00427	RNaseP_nuc links to Rfam database...	0.48	0.43	0.54	20	40718	27	1	16	10	26
ASE_00441	RNaseP_bact_a links to Rfam database...	0.63	0.44	0.91	49	64207	9	0	5	4	63
SRP_00006	Metazoa_SRP links to Rfam database...	0.96	0.92	1.00	93	45660	2	0	0	2	8
SRP_00011	Plant_SRP links to Rfam database...	0.81	0.77	0.86	80	46267	13	0	13	0	24
SRP_00015	Plant_SRP links to Rfam database...	0.92	0.86	0.99	85	46274	2	0	1	1	14
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.56	0.34	0.91	30	37642	3	0	3	0	57
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.56	0.34	0.91	30	36823	3	0	3	0	58
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.57	0.35	0.91	31	36822	3	0	3	0	57
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.55	0.34	0.91	30	36282	3	0	3	0	59
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.57	0.36	0.91	31	36551	3	0	3	0	56
SRP_00050	Metazoa_SRP links to Rfam database...	0.97	0.96	0.99	95	44754	5	0	1	4	4
SRP_00066	Metazoa_SRP links to Rfam database...	0.82	0.76	0.89	76	45366	11	0	9	2	24
SRP_00086	Metazoa_SRP links to Rfam database...	0.93	0.93	0.94	93	44154	10	0	6	4	7
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.56	0.35	0.91	31	34157	3	0	3	0	58
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.55	0.33	0.91	30	35745	3	0	3	0	60
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.56	0.34	0.91	31	35477	3	0	3	0	59
SRP_00102	Metazoa_SRP links to Rfam database...	0.82	0.79	0.85	80	44457	17	5	9	3	21
SRP_00103	Metazoa_SRP links to Rfam database...	0.85	0.81	0.89	83	45358	12	1	9	2	19
SRP_00152	Plant_SRP links to Rfam database...	0.93	0.89	0.98	92	45659	3	0	2	1	11
SRP_00171	Metazoa_SRP links to Rfam database...	0.56	0.45	0.69	40	45393	18	1	17	0	48
SRP_00178	Plant_SRP links to Rfam database...	0.88	0.81	0.95	83	45666	6	0	4	2	19
SRP_00179	Plant_SRP links to Rfam database...	0.89	0.81	0.98	85	45969	6	0	2	4	20
SRP_00181	Plant_SRP links to Rfam database...	0.80	0.73	0.88	74	45972	12	0	10	2	28
SRP_00182	Plant_SRP links to Rfam database...	0.83	0.75	0.93	76	45974	8	0	6	2	25
SRP_00188	Plant_SRP links to Rfam database...	0.84	0.76	0.94	60	31061	6	0	4	2	19
SRP_00228	Metazoa_SRP links to Rfam database...	0.95	0.93	0.98	88	45361	8	0	2	6	7
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.55	0.34	0.91	29	36283	3	0	3	0	57
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.56	0.34	0.91	30	36282	3	0	3	0	58
SRP_00317	Metazoa_SRP links to Rfam database...	0.94	0.91	0.97	89	45058	10	0	3	7	9
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.51	0.44	0.59	17	35216	17	7	5	5	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.55	0.33	0.91	30	35478	4	0	3	1	61
SRP_00347	Metazoa_SRP links to Rfam database...	0.94	0.92	0.97	88	46574	8	0	3	5	8
SRP_00368	Metazoa_SRP links to Rfam database...	0.91	0.89	0.94	87	43863	9	0	6	3	11
TMR_00017	tmRNA links to Rfam database...	0.72	0.55	0.93	56	67101	8	0	4	4	46
TMR_00018	tmRNA links to Rfam database...	0.71	0.60	0.85	55	64555	14	2	8	4	37
TMR_00042	tmRNA links to Rfam database...	0.74	0.64	0.85	63	62761	15	1	10	4	35
TMR_00046	tmRNA links to Rfam database...	0.64	0.53	0.77	51	62769	20	3	12	5	45
TMR_00048	tmRNA links to Rfam database...	0.73	0.63	0.85	60	64909	18	2	9	7	35
TMR_00080	tmRNA links to Rfam database...	0.60	0.36	0.97	35	70464	1	0	1	0	61
TMR_00082	tmRNA links to Rfam database...	0.65	0.44	0.95	42	67852	3	0	2	1	54
TMR_00123	tmRNA links to Rfam database...	0.69	0.55	0.86	56	66365	14	0	9	5	45
TMR_00137	tmRNA links to Rfam database...	0.47	0.28	0.78	25	61043	12	1	6	5	64
TMR_00142	tmRNA links to Rfam database...	0.61	0.55	0.68	56	70794	33	7	19	7	46
TMR_00207	tmRNA links to Rfam database...	0.76	0.60	0.95	62	72325	7	0	3	4	41
TMR_00257	tmRNA links to Rfam database...	0.71	0.54	0.93	53	67104	10	0	4	6	45
TMR_00271	tmRNA links to Rfam database...	0.54	0.35	0.82	32	64222	15	3	4	8	59
TMR_00332	tmRNA links to Rfam database...	0.75	0.62	0.92	61	67095	10	0	5	5	38
TMR_00366	tmRNA links to Rfam database...	0.65	0.57	0.74	57	67819	31	5	15	11	43
TMR_00378	tmRNA links to Rfam database...	0.63	0.53	0.76	51	67829	26	6	10	10	46
TMR_00404	tmRNA links to Rfam database...	0.66	0.57	0.76	52	67460	27	3	13	11	40
TMR_00427	tmRNA links to Rfam database...	0.73	0.59	0.90	57	67465	11	5	1	5	40
TMR_00443	tmRNA links to Rfam database...	0.69	0.55	0.86	57	67095	13	1	8	4	47
TMR_00451	tmRNA links to Rfam database...	0.54	0.36	0.80	32	63506	12	3	5	4	57
TMR_00458	tmRNA links to Rfam database...	0.61	0.41	0.90	38	63504	7	3	1	3	55
TMR_00469	tmRNA links to Rfam database...	0.79	0.70	0.90	70	64542	11	4	4	3	30
TMR_00472	tmRNA links to Rfam database...	0.77	0.66	0.89	64	64548	13	5	3	5	33
TMR_00519	tmRNA links to Rfam database...	0.61	0.46	0.80	44	63135	20	2	9	9	51
TMR_00520	tmRNA links to Rfam database...	0.60	0.47	0.76	47	63128	24	3	12	9	52
TMR_00522	tmRNA links to Rfam database...	0.65	0.47	0.88	46	63138	14	2	4	8	51
TMR_00528	tmRNA links to Rfam database...	0.60	0.46	0.78	45	63132	22	4	9	9	52
TMR_00540	tmRNA links to Rfam database...	0.69	0.54	0.88	56	73472	11	2	6	3	48
TMR_00568	tmRNA links to Rfam database...	0.69	0.54	0.88	53	60666	15	0	7	8	46
TMR_00571	tmRNA links to Rfam database...	0.66	0.49	0.89	49	60671	14	1	5	8	50
TMR_00580	tmRNA links to Rfam database...	0.65	0.49	0.88	49	60670	14	1	6	7	51
TMR_00584	tmRNA links to Rfam database...	0.72	0.57	0.92	55	61015	13	1	4	8	42
TMR_00586	tmRNA links to Rfam database...	0.70	0.56	0.89	54	61014	14	1	6	7	43
TMR_00616	tmRNA links to Rfam database...	0.76	0.63	0.91	62	67093	11	0	6	5	37
TMR_00699	tmRNA links to Rfam database...	0.76	0.63	0.91	64	67091	11	1	5	5	38
TMR_00702	tmRNA links to Rfam database...	0.77	0.65	0.90	65	67089	12	1	6	5	35
TMR_00703	tmRNA links to Rfam database...	0.78	0.66	0.92	65	67457	11	1	5	5	34

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]