CompaRNA - on-line benchmarks of RNA structure prediction methods

FAQ

Metric	CentroidHomfold‑LAST		RNASampler(seed)
MCC	0.807	>	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.131	>	0.774 ± 0.092
Sensitivity	0.729	>	0.659
Positive Predictive Value	0.894	<	0.921
Total TP	489	>	442
Total TN	413695	<	413762
Total FP	126	>	105
Total FP CONTRA	21	>	9
Total FP INCONS	37	>	29
Total FP COMP	68	>	67
Total FN	182	<	229
P-value	1.69265863073e-08

Comparison of performance of CentroidHomfold-LAST and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).

Total Scores
MCC	0.807
Average MCC ± 95% Confidence Intervals	0.774 ± 0.131
Sensitivity	0.729
Positive Predictive Value	0.894
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.72	0.69	0.75	27	21285	17	7	2	8	12
RFA_00620	Telomerase-cil links to Rfam database...	0.23	0.15	0.35	6	21928	16	1	10	5	33
RFA_00626	rne5 links to Rfam database...	0.85	0.79	0.92	69	56541	13	1	5	7	18
RFA_00627	rne5 links to Rfam database...	0.86	0.75	0.98	65	56887	13	0	1	12	22
RFA_00628	rne5 links to Rfam database...	0.86	0.78	0.94	67	57220	7	1	3	3	19
RFA_00630	rne5 links to Rfam database...	0.87	0.83	0.92	72	56875	10	1	5	4	15
RFA_00814	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	25162	6	0	0	6	3
RFA_00815	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	24496	1	0	0	1	6
RFA_00816	R2_retro_el links to Rfam database...	0.80	0.63	1.00	26	23194	1	0	0	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.59	0.80	24	21915	9	2	4	3	17
RFA_00818	R2_retro_el links to Rfam database...	0.57	0.54	0.61	22	20265	18	8	6	4	19
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.93	0.97	38	27927	15	0	1	14	3

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.