CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	ContextFold		CMfinder(seed)
MCC	0.800	>	0.454
Average MCC ± 95% Confidence Intervals	0.776 ± 0.051	>	0.456 ± 0.042
Sensitivity	0.774	>	0.271
Positive Predictive Value	0.827	>	0.762
Total TP	3563	>	1249
Total TN	2620384	<	2623051
Total FP	986	>	419
Total FP CONTRA	159	>	30
Total FP INCONS	584	>	360
Total FP COMP	243	>	29
Total FN	1040	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of ContextFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ContextFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and CMfinder(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP	3563
Total TN	2620384
Total FP	986
Total FP CONTRA	159
Total FP INCONS	584
Total FP COMP	243
Total FN	1040

Total Scores
MCC	0.800
Average MCC ± 95% Confidence Intervals	0.776 ± 0.051
Sensitivity	0.774
Positive Predictive Value	0.827
Nr of predictions	51

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.67	0.60	0.76	69	103649	34	4	18	12	46
CRW_00016	Intron_gpI links to Rfam database...	0.81	0.73	0.92	87	77326	14	3	5	6	33
CRW_00610	Intron_gpI links to Rfam database...	0.87	0.80	0.94	65	36246	7	1	3	3	16
CRW_00613	Intron_gpI links to Rfam database...	0.47	0.42	0.53	33	34918	36	3	26	7	45
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.14	0.14	8	121715	98	13	35	50	49
CRW_00618	Intron_gpI links to Rfam database...	0.21	0.21	0.21	13	56218	64	9	40	15	48
CRW_00633	Intron_gpI links to Rfam database...	0.81	0.75	0.86	80	63453	15	4	9	2	26
CRW_00634	Intron_gpI links to Rfam database...	0.62	0.62	0.62	58	64526	36	9	27	0	36
CRW_00670	Intron_gpI links to Rfam database...	0.86	0.83	0.90	99	70015	11	4	7	0	21
CRW_00671	Intron_gpI links to Rfam database...	0.83	0.79	0.88	92	62731	12	3	9	0	25
CRW_00672	Intron_gpI links to Rfam database...	0.86	0.84	0.89	93	72285	13	4	8	1	18
CRW_00674	Intron_gpI links to Rfam database...	0.81	0.77	0.85	95	83324	19	1	16	2	29
CRW_00676	Intron_gpI links to Rfam database...	0.60	0.57	0.63	66	93424	41	9	29	3	49
CRW_00692	Intron_gpI links to Rfam database...	0.77	0.73	0.81	66	68554	24	6	9	9	24
PDB_00827	Intron_gpI links to Rfam database...	0.79	0.65	0.96	53	26973	3	0	2	1	28
RFA_00606	Telomerase-cil links to Rfam database...	0.45	0.44	0.47	17	21285	23	10	9	4	22
RFA_00620	Telomerase-cil links to Rfam database...	0.58	0.54	0.62	21	21911	27	3	10	14	18
RFA_00626	rne5 links to Rfam database...	0.80	0.75	0.87	65	56541	19	1	9	9	22
RFA_00627	rne5 links to Rfam database...	0.76	0.71	0.81	62	56876	16	3	12	1	25
RFA_00628	rne5 links to Rfam database...	0.60	0.56	0.65	48	57217	28	3	23	2	38
RFA_00630	rne5 links to Rfam database...	0.62	0.60	0.65	52	56873	35	3	25	7	35
RFA_00639	7SK links to Rfam database...	0.64	0.63	0.65	55	54531	39	7	22	10	32
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.93	0.95	38	25160	18	0	2	16	3
RFA_00815	R2_retro_el links to Rfam database...	0.74	0.83	0.65	34	24479	21	13	5	3	7
RFA_00816	R2_retro_el links to Rfam database...	0.67	0.71	0.63	29	23174	22	13	4	5	12
RFA_00817	R2_retro_el links to Rfam database...	0.58	0.59	0.59	24	21904	17	5	12	0	17
RFA_00818	R2_retro_el links to Rfam database...	0.61	0.66	0.56	27	20253	29	10	11	8	14
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	15	0	1	14	2
SRP_00016	Archaea_SRP links to Rfam database...	0.89	0.86	0.92	94	47793	8	1	7	0	15
SRP_00130	Archaea_SRP links to Rfam database...	0.83	0.81	0.85	79	49677	17	1	13	3	18
SRP_00142	Archaea_SRP links to Rfam database...	0.96	0.96	0.97	89	45964	6	0	3	3	4
SRP_00143	Archaea_SRP links to Rfam database...	0.87	0.86	0.88	87	49671	17	1	11	5	14
SRP_00144	Archaea_SRP links to Rfam database...	0.94	0.93	0.96	87	46574	9	0	4	5	7
SRP_00197	Archaea_SRP links to Rfam database...	0.91	0.88	0.95	89	49361	5	0	5	0	12
SRP_00198	Archaea_SRP links to Rfam database...	0.91	0.88	0.95	91	50944	5	0	5	0	12
SRP_00199	Archaea_SRP links to Rfam database...	0.86	0.84	0.89	88	50941	12	0	11	1	17
SRP_00201	Archaea_SRP links to Rfam database...	0.90	0.87	0.92	97	47790	10	0	8	2	14
SRP_00202	Archaea_SRP links to Rfam database...	0.97	0.97	0.98	113	54170	3	0	2	1	4
SRP_00203	Archaea_SRP links to Rfam database...	0.86	0.87	0.85	91	48721	22	0	16	6	14
SRP_00204	Archaea_SRP links to Rfam database...	0.86	0.84	0.88	86	49043	13	1	11	1	16
SRP_00206	Archaea_SRP links to Rfam database...	0.87	0.83	0.90	90	47795	10	5	5	0	18
SRP_00208	Archaea_SRP links to Rfam database...	0.88	0.84	0.91	85	46572	10	2	6	2	16
SRP_00255	Archaea_SRP links to Rfam database...	0.85	0.86	0.84	81	47489	19	0	16	3	13
SRP_00276	Archaea_SRP links to Rfam database...	0.94	0.92	0.95	101	50615	5	0	5	0	9
SRP_00278	Archaea_SRP links to Rfam database...	0.83	0.82	0.85	86	45955	15	0	15	0	19
SRP_00321	Archaea_SRP links to Rfam database...	0.80	0.79	0.82	85	47482	19	3	16	0	23
SRP_00322	Archaea_SRP links to Rfam database...	0.94	0.94	0.94	102	48408	6	0	6	0	7
SRP_00323	Archaea_SRP links to Rfam database...	0.96	0.94	0.98	101	47175	3	0	2	1	6
SRP_00330	Archaea_SRP links to Rfam database...	0.89	0.86	0.91	82	49996	11	0	8	3	13
SRP_00332	Archaea_SRP links to Rfam database...	0.91	0.89	0.93	94	50302	7	0	7	0	12
SRP_00339	Archaea_SRP links to Rfam database...	0.83	0.82	0.84	77	44459	18	1	14	3	17

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

2. Individual counts for ContextFold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]