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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Cylofold [.zip] - may take several seconds...


Overview

Metric ContextFold Cylofold
MCC 0.944 > 0.271
Average MCC ± 95% Confidence Intervals 0.944 ± 0.079 > 0.275 ± 1.303
Sensitivity 0.905 > 0.241
Positive Predictive Value 0.984 > 0.308
Total TP 124 > 33
Total TN 60462 < 60481
Total FP 9 < 78
Total FP CONTRA 2 < 3
Total FP INCONS 0 < 71
Total FP COMP 7 > 4
Total FN 13 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Cylofold).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 124
Total TN 60462
Total FP 9
Total FP CONTRA 2
Total FP INCONS 0
Total FP COMP 7
Total FN 13
Total Scores
MCC 0.944
Average MCC ± 95% Confidence Intervals 0.944 ± 0.079
Sensitivity 0.905
Positive Predictive Value 0.984
Nr of predictions 2

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00408 - 0.95 0.93 0.97 66 32317 6 2 0 4 5
ASE_00429 - 0.94 0.88 1.00 58 28145 3 0 0 3 8

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 33
Total TN 60481
Total FP 78
Total FP CONTRA 3
Total FP INCONS 71
Total FP COMP 4
Total FN 104
Total Scores
MCC 0.271
Average MCC ± 95% Confidence Intervals 0.275 ± 1.303
Sensitivity 0.241
Positive Predictive Value 0.308
Nr of predictions 2

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00408 - 0.17 0.15 0.20 11 32329 45 3 42 0 60
ASE_00429 - 0.38 0.33 0.43 22 28152 33 0 29 4 44

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

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